DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and Mastl

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_080255.3	Gene:	Mastl / 67121	MGIID:	1914371	Length:	865	Species:	Mus musculus

Alignment Length:	862	Identity:	208/862 - (24%)
Similarity:	325/862 - (37%)	Gaps:	223/862 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   807 AGAEGITGGSAATATGSGAQQPSPQE-NDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNN 870
            :.:|...||:|.....|....|.|.. .:|.|||.||.||:|.|||  .:...:.:|:|.:.|.:
Mouse     5 SASEENEGGAAIEECVSRIPVPRPPSIEEFTIVKPISRGAFGKVYL--GQKGGKLYAVKVVKKAD 67

  Fly   871 LILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMA 935
            :|.:|...||.||||.|:.:.:||||.:|.|.::..::.|:|||:.|||..:||...|....:||
Mouse    68 MINKNMTHQVQAERDALALSKSPFVVHLYYSLQSASNIYLIMEYLIGGDVKSLLHIYGYFDEEMA 132

  Fly   936 RFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSET 1000
            ..|.:|..||::|||.:||:||||||||:||:..||||||||||||:.|               .
Mouse   133 IKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTL---------------N 182

  Fly  1001 RQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFF---GETTEE---LF-- 1057
            |..:...:..||....|    :|.|.:     :.|.:|  .||..:.||   ||..::   :|
Mouse   183 RDINMMDILTTPSMSKP----KQDYSR-----TPGQVL--SLISSLGFFTPVGEKDQDSANMFSA 236

  Fly  1058 ---AHTVNDDIEWPDSEDWPVQAEAKDIISQLLQ-------QNP--------------RDRLGTQ 1098
               |..::.....|.|.|   |.|.....|:||:       .||              |.||||.
Mouse   237 PKSAAQLSRGFICPMSVD---QKEPTSYSSKLLKSCFETLSSNPEIPVKCLTSNLLQCRKRLGTS 298

  Fly  1099 S---------GALEMKEH-------------EYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTR 1141
            |         .::|.:.|             .....|.||::         ::.:...||...|:
Mouse   299 STSSQSHTFVSSVESECHSNPKWERDCQSTESSGCAMSWNAV---------EMLYAKSTSAIKTK 354

  Fly  1142 MDRYNHDLGGEDTDDTDDTPVFGSFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSR 1206
            .:.   :|......|:...|..||.....|:...:..||.                       :|
Mouse   355 TEL---ELALSPIHDSSAIPAAGSNQVTLPRKCFREISWE-----------------------AR 393

  Fly  1207 AQETPAATVGATSTGALPKLKSGMGSGSGSGSGSGSGSASHDGVVNKFLN------TPQLRKLDL 1265
            ..:....|:        .|.:||....|.....|.:.|..|.|..|...|      :|....:..
Mouse   394 DPDNENMTI--------DKGQSGFCQSSQRSVNSSATSEEHLGKRNYKRNFHLVDSSPCQEIMQS 450

  Fly  1266 SSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQQPNPGATQRMQQRHSMPPNTTTIIST 1330
            ..:|.:..:..:..   ....|.:.|...|::.||       ....:..|..::...|..|.::.
Mouse   451 KKNCTEYEANKERQ---GCRANQSTGLTTEVQNLK-------LSGCESQQLDYANKENIVTYLTD 505

  Fly  1331 PATPP----PTQTQATMAATPPTATVGS----FSRSTPESSQ--------TDSDDFSPQINRKRK 1379
            ..||.    ||..:..|:.......:.|    .|.::..|.:        .|||...|.::....
Mouse   506 RQTPEKLHIPTIAKNLMSELDEDCELSSKKDCLSSNSVCSDEDRALKTTCVDSDSSFPGVSMMES 570

  Fly  1380 GVCARDILPRFSI---SIED---ETISAGSSSTENMNLPREQSPLALQ-------HQPKSMDGST 1431
            .:..:.:.|..||   |.|:   |.:.......|| :||::.....:|       |..|:....|
Mouse   571 SLEIQALEPDKSIRDYSFEEPNTEDLFVLPKCQEN-SLPQDDCHACIQDSSQVSAHPSKAPKALT 634

  Fly  1432 SGSSVKHHRSRSIVKSASALG----LSLMTSLDNSQLAAQLCG----IQSPGGGGNGSSTASSRD 1488
            |..:|...||.:...:||...    :|: ||||...::....|    ..||...|...::..:.:
Mouse   635 SKINVVAFRSFNSHINASTNSEPSKISI-TSLDAMDISCDYSGSYPMAVSPTEKGRHYTSHQTPN 698

  Fly  1489 TSPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDE----GSPAFE 1549
            .      ..|.|:.:.|..:|||                          ...||:    |:|.:
Mouse   699 Q------VKLGTSYRTPKSVRRG--------------------------AAPVDDGRILGTPDY- 730

  Fly  1550 AGLRPADLITHVNGEAV 1566
              |.|..|:...:|.||
Mouse   731 --LAPELLLGTAHGPAV 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070
		STKc_MAST	834..1115	CDD:270760	109/334 (33%)
		S_TKc	835..1110	CDD:214567	108/328 (33%)
		PDZ_signaling	1506..1587	CDD:238492	13/65 (20%)
Mastl	NP_080255.3	STKc_MASTL	29..>222	CDD:270761	86/220 (39%)
		S_TKc	34..>194	CDD:214567	75/176 (43%)
		PKc_like	<658..856	CDD:304357	25/124 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900