Protein Alignment dop and SGK1

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: NP_001137148.1
• Gene: SGK1 / 6446
• HGNCID: 10810
• Length: 526
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 108/318 - (33%)
• Similarity: 178/318 - (55%)
• Gaps: 22/318 - (6%)

  Fly   825 AQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDI-LS 888
            :..|..:.:||..:|:|..|::|.|.|.:||.....:|:|.:.|..::.:.:.:.:.:||:: |.
Human   183 SSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLK 247

  Fly   889 FADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYG 953
            ...:||:|.::.||:|...|..|::|:.||:....|:.........||||.||...|:.||||..
Human   248 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN 312

  Fly   954 IVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPE 1018
            ||:|||||:|:|:.:.|||.||||||.|..:..          :|.|..|.     |||||:|||
Human   313 IVYRDLKPENILLDSQGHIVLTDFGLCKENIEH----------NSTTSTFC-----GTPEYLAPE 362

  Fly  1019 VILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDII 1083
            |:.:|.|.:.||||.:|.:|||.|.|..||:...|.|::.:.:|..::...:    :...|:.::
Human   363 VLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN----ITNSARHLL 423

  Fly  1084 SQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQK--AEFVPQLSHDDDTSYFD 1139
            ..|||::...|||.:...:|:|.|.:|..::|:.|:.:|  ..|.|.:|..:|..:||
Human   424 EGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFD 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637
		STKc_MAST	834..1115	CDD:270760	98/281 (35%)
		PDZ_MAST	1502..1594	CDD:467189
SGK1	NP_001137148.1	STKc_SGK	197..519	CDD:270727	105/304 (35%)