Protein Alignment dop and Mast3

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: NP_001389902.1
• Gene: Mast3 / 546071
• MGIID: 2683541
• Length: 1336
• Species: Mus musculus
• Alignment Length: 1767
• Identity: 659/1767 - (37%)
• Similarity: 861/1767 - (48%)
• Gaps: 468/1767 - (26%)

  Fly   202 ALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLTGNYFRHELTAPLPVQP--PGFGAS 264
            :|||:          |.:..|.|...|.|..|....:|||        |:...|..|  |..|..
Mouse     5 SLLRR----------RGLQKELSLPRRGRGLSPSSQSPCL--------LSPGSPCSPCSPSLGLQ 51

  Fly   265 PLGGHNISRSGSCAGIGLAKHHHHHHLHGVVMRGSAGGGAGSGGGSSSGVAHHRLSLVTNSAAVA 329
            |..    .|||                                         :|.|||..:.:..
Mouse    52 PWS----CRSG-----------------------------------------NRKSLVVGTPSPT 71

  Fly   330 AAGGSRTHSPYSA-----SPVDSPRLNSPMPFAFAPIKRIASCRGVVADGRRWSVASLPSSGYGT 389
            .   ||..||.|.     ||:||||..|.......|..|.....|..|||||||:||||||||||
Mouse    72 L---SRPLSPLSVPTAGNSPLDSPRNFSAAAAISFPFARSHLSHGDRADGRRWSLASLPSSGYGT 133

  Fly   390 TPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQL 454
            ...||.:||..||:|.|:||     |....||.         ...|.:|
Mouse   134 NTPSSTVSSSSSSRERLHQL-----PFQPTADE---------LRFLSKH---------------- 168

  Fly   455 TPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSPYF 519
                                                          ..||.|...:.||| ||..
Mouse   169 ----------------------------------------------FRSSESVVDEDGGR-SPRL 186

  Fly   520 RPRSRSLSSPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFRDSQPIVR 584
            ||||||||....|...||||.:||.:|:|||||||.|||.||:.|:.........:..|.  ::.
Mouse   187 RPRSRSLSPGRTSGTFDNEIVMMNHVYRERFPKATAQMEGRLQDFLAAFAPGDRLALADG--VLG 249

  Fly   585 FVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKSPEAAAELNGV---IKKLLLI 646
            |:|||::|:|||||.||...|:||:||.|:.:.|||||.:..|:|.  :||:..:   ::|||:|
Mouse   250 FIHHQIVELARDCLAKSGEALVTSRYFLEMQDKLERLLQDAHERSD--SAEVGFIVQLVRKLLII 312

  Fly   647 ISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAELQ--QELRE 709
            |||||||||||||||:|||.|||||||.|:....:|.|:|:|||.:|||.:||:.|:|  .:|.|
Mouse   313 ISRPARLLECLEFDPEEFYHLLEAAEGQAREDQGVKTDLPRYIIRQLGLAKDPLEEIQPLNDLDE 377

  Fly   710 TQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATC 774
            :|            |..||      ||
Mouse   378 SQ------------PPAPG------SP-------------------------------------- 386

  Fly   775 DTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPSPQENDFDIVK 839
                          |.:|     :||.|..|                        |.|:||:.:|
Mouse   387 --------------ESRG-----LGGPSRRK------------------------PCESDFETIK 408

  Fly   840 LISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFET 904
            |||||||||||||:|:.||||||:|||||.|||||||::|||.|||||:||:|||||.|:|||||
Mouse   409 LISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVGMFCSFET 473

  Fly   905 KKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITAL 969
            ::|||:||||||||||.|||||:||||.||||.||||||||:||||:||||||||||||||||:|
Mouse   474 RRHLCMVMEYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSL 538

  Fly   970 GHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSM 1034
            ||||||||||||:||||:|||||||:|:.:.|:|.||||.|||||||||||.|||||||||||:|
Mouse   539 GHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFVDKQVCGTPEYIAPEVIFRQGYGKPVDWWAM 603

  Fly  1035 GIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQS 1099
            |:||||||:|||||||:|.||||...|:|:|.||:.:: .:..:|:|:|::||:|:|.||||| .
Mouse   604 GVILYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDE-ALPLDAQDLITRLLRQSPMDRLGT-G 666

  Fly  1100 GALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDTDDTPVFG 1164
            |..|:|:|.:||.:||..|||.||||||||..:|||||||||.:||.| ||.|| |:|:|.
Mouse   667 GTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFDTRSERYRH-LGSED-DETNDE---- 725

  Fly  1165 SFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGATSTGALPKLKSG 1229
            ..::..||:....:.:|:..:.:.....:||        |:.|:.:               ....
Mouse   726 ESSTEIPQFSSCSHRFSKVYSSSEFLAVQPT--------PTFAERS---------------FSED 767

  Fly  1230 MGSGSGSGSGSGSGSASHDGVVNKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDA 1294
            ...|.|...|......|.|         .:||....:|||.......|....|.||.  ||..|.
Mouse   768 REDGWGQSLGDRGRRLSAD---------LRLRSWTPASSCQPSSCQTDRGPSPSLLS--TISLDV 821

  Fly  1295 ELRMLKHYLQQPNPGATQRMQQRHSMPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRST 1359
               |.|......:.||:.....    |.....|:..|..||||        ||.|....:.|..|
Mouse   822 ---MPKFAFSSEDEGASSGPAD----PQKPVFILGEPDPPPPT--------TPVTPKPCNLSADT 871

  Fly  1360 PESSQTDSDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQP 1424
            ...|..       ::.....|  ||...||        .:.||..  ..:...|:..|    .:|
Mouse   872 AVLSHA-------RLRSNSTG--ARHSTPR--------PLDAGRG--RRLGGSRDPGP----EKP 913

  Fly  1425 KSMDGSTSGSSVKHHRSRSIVKSASALGLSLMTSLDNSQLAAQLCGIQSPGGGGNGSSTASSRDT 1489
            ::..|.:.|         .:.||||...|||:.:.|:.....    :.||....:.||..||||:
Mouse   914 RASPGGSGG---------RVPKSASVSALSLIITADDGSGGP----LMSPLSPRSLSSNPSSRDS 965

  Fly  1490 SPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRP 1554
            ||.|:.||:..:|:|||:|....:.:||::..||||.||:|.||:||:|.:|:|||||.|||||.
Mouse   966 SPSRDPSPVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEEGSPAQEAGLRA 1030

  Fly  1555 ADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQ 1619
            .|||||:|||:|.||.|..|::|||..|..::||.|.||:|||:.|..::::.:.::|     |:
Mouse  1031 GDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMA-----RR 1090

  Fly  1620 KKQTKREHDKKRKTSLFRRISSKRANAEMQQYSAGTSSPTTPSARNLSPLDSSYHSSCCQSAANS 1684
            .|:::|...:.|:.|||:|||.                   ||        |..|:|  :|.::.
Mouse  1091 SKRSRRRETQDRRKSLFKRISK-------------------PS--------SVLHTS--RSFSSG 1126

  Fly  1685 SSQSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALS-VQLPSAPPPTQLVLLPHVGAVVGSNP 1748
            ...|.|.|.|.|.:||.|             ::||..: .:.|:...||.....|:|      :|
Mouse  1127 LQHSLSSSESLPGSPTHS-------------LSPSPTTPCRSPAPDAPTDTASPPNV------SP 1172

  Fly  1749 TSVGNVPVSP-TGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPN 1812
            :|  :.|.|| ||     :.|||:||||..||          |...:.:|
Mouse  1173 SS--SSPASPATG-----HTRPSSLHGLAAKL----------GPPRHKSG--------------- 1205

  Fly  1813 RRKSVGHIPLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSYSP----GSTLPTLQ 1873
            ||||...||.||||..|.|:|    |.||||||.    ||.|     ..:.||    |.:...|.
Mouse  1206 RRKSTSSIPPSPLACPPVPTP----PPRSPSPLP----GHIP-----IPARSPRLRRGQSADKLG 1257

  Fly  1874 TAVNANTKKAGFARTKSAEPSSPLLRRA-LSP--DRLHPRSAETKIS----PLCCSPPIKQPTHQ 1931
            ...:......|..|.:.||....::||. ||.  |....:.|..::|    |   .||...|
Mouse  1258 LGTSERLDGDGGRRARGAEAELVVMRRLHLSERRDSFKKQEAVQEVSFDEEP---GPPRGVP--- 1316

  Fly  1932 RVVTTTWRSTPG 1943
            ::......:|||
Mouse  1317 KIAVQGAEATPG 1328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	147/360 (41%)
		STKc_MAST	834..1115	CDD:270760	206/280 (74%)
		PDZ_MAST	1502..1594	CDD:467189	51/91 (56%)
Mast3	NP_001389902.1	DUF1908	88..368	CDD:462637	147/360 (41%)
		STKc_MAST	403..682	CDD:270760	206/280 (74%)
		PDZ_MAST3	978..1071	CDD:467288	52/92 (57%)