Protein Alignment dop and ppk18

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: NP_001018270.2
• Gene: ppk18 / 3361535
• PomBaseID: SPAPB18E9.02C
• Length: 1318
• Species: Schizosaccharomyces pombe
• Alignment Length: 909
• Identity: 230/909 - (25%)
• Similarity: 372/909 - (40%)
• Gaps: 246/909 - (27%)

  Fly   637 NGVIKKLLLIISRPARLL------EC-LEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLG 694
            :.::||.|..|:|.:.::      .| :|...|...|.....:|:.:.:......:.:.|...|
pombe   351 DALVKKKLDAINRLSNIIYYSERVRCEIEDQVQTIIEQSIQVDGYDEPLSTTTPTLIEPIQETL- 414

  Fly   695 LNRDPIAELQ-----------QELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSS-- 746
            :.:.||.|.:           :|:.:..|.....     ||           |:|:|:...|:
pombe   415 MTQSPIIECEPFNTVKPSVSPEEVHDISQFNHRN-----DP-----------PITAASVDSSNSF 463

  Fly   747 ----LALDAIAMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKG-GSSSAVGGGSSSK- 805
                .:.:..:.:|||...:.:.....|:|      |...::|.:|...| |||........||
pombe   464 SVHRSSTNHSSTNSGSPNLSRRNNLAIPIA------SRRKSVSAVNTLYGVGSSYTSESFPFSKL 522

  Fly   806 ------------------VAGAEGITGGSAATATGSGAQQPSPQENDFDIVKLISNGAYGAVYLV 852
                              ::...||:..|:..::|.|    :|...|::|:|.||.|.:|.|||.
pombe   523 TVPVERNSFRETESPKPFLSRQIGISTLSSNISSGKG----TPSIQDYEIIKPISKGTFGTVYLS 583

  Fly   853 KHKTTRQRFAMKKINKNNLILRNQVEQVFAERDIL-SFADNPFVVSMYCSFETKKHLCLVMEYVE 916
            :..||.:.:|:|.:.|.::|.:|||..|.|||.:| :..::.||..:|.:|:::.:|.||||::.
pombe   584 RKNTTGEIYAIKVLRKVDMISKNQVANVKAERAVLMAQEESAFVAKLYYAFQSRDYLYLVMEFMN 648

  Fly   917 GGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSK 981
            ||||.:|||::..:|...|:.|.||..|.:|:||..||:|||:||||:|::..||:||.|||||:
pombe   649 GGDCASLLKSLYTIPESWAKIYIAEVALGLEHLHRLGIIHRDIKPDNILMSITGHLKLADFGLSQ 713

  Fly   982 MGLMSLATNLYEG---------------------------------------------------- 994
            :||.:....|.:|
pombe   714 LGLTTRQLRLQKGKNNILSPPSFQSPTALGDPGDNIASSPLILPTSVSAFSYDEKSQKQKTELAT 778

  Fly   995 ---------------YIDSETRQF--------------------------SDKQVYGTPEYIAPE 1018
                           .|||.:.::                          :.|:..|||:|:|||
pombe   779 FTTYKEDDTTTTTRTSIDSISSKYLESPVDSQKVNRTPNLQSVPFFRQPDAPKRFVGTPDYLAPE 843

  Fly  1019 VILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDII 1083
            .:........||||::|.:|:|||.|..||..||.|::|.:.:.::|.|||.|.:|...||.|:|
pombe   844 TLRGSTQDDMVDWWALGCVLFEFLFGYPPFHAETPEKVFENILANNIAWPDLEMYPCSEEALDLI 908

  Fly  1084 SQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTR------- 1141
            :..||.||..|||. |...|:|||.:|.|::|:.:...:|.|:|......||:|||:|
pombe   909 NGFLQPNPERRLGF-SDINEIKEHPFFNGINWDDIFSHEAPFIPAPETPLDTAYFDSRGAGAAES 972

  Fly  1142 -MDRYNHDLGGEDTDDTDDTPVFGSFNSYTPQYRKQHYSWSRHATPTST------------DGAK 1193
             |.. :.:.|.|.:.|.:.:...||      |:.:..:..||..:.::.            |...
pombe   973 NMSS-SVNSGEEVSKDNNVSQERGS------QFLRSSHGRSRERSTSARRSRRFSEANSEFDEFG 1030

  Fly  1194 PTGPPPLSSLPSRAQETPAATVGATSTGAL----PKLKSGMGSGSGSGS---------------- 1238
            |.....||.| .||.......:.:...|.|    |....|...||...|
pombe  1031 PFSYKNLSVL-ERANRNAIEKIRSEIAGKLHISPPDPHIGYTPGSDMPSAKLYDQQLTLSPSLMT 1094

  Fly  1239 GSGSGSASHDGVVNKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYL 1303
            ..||..:|.|....|.:|          ||.::..|..|.   |:.:|::.    .:|.|.||
pombe  1095 NQGSNFSSTDSTPRKSIN----------SSDVESRSKTDG---PKSMHDLI----KQLHMRKH-- 1140

  Fly  1304 QQPNPGATQRMQQRHSMPP----NTTTIISTPATPPP---TQTQATMAATPPTATVGSFSRSTP 1360
                  ::...|...|...    |....||...|..|   .:.||:..::|.:.|...||.|.|
pombe  1141 ------SSHTNQSTGSSESDDLFNLDLPISNLETSYPFKIEEGQASPLSSPLSKTPPFFSSSVP 1198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	14/71 (20%)
		STKc_MAST	834..1115	CDD:270760	123/374 (33%)
		PDZ_MAST	1502..1594	CDD:467189
ppk18	NP_001018270.2	Protein Kinases, catalytic domain	569..940	CDD:473864	121/371 (33%)