Protein Alignment dop and Mast4

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: XP_017171016.1
• Gene: Mast4 / 328329
• MGIID: 1918885
• Length: 2658
• Species: Mus musculus
• Alignment Length: 2232
• Identity: 755/2232 - (33%)
• Similarity: 1017/2232 - (45%)
• Gaps: 688/2232 - (30%)

  Fly    36 LGSKISTS---TPQKNDEHQEQEFINQSVASEIEAMSISDSASAESSSGATATATATMSGSP--- 94
            :|.|:|.:   .|:....|..     :::.|...|:|...::|||||||   :.|.:..|.|
Mouse     1 MGEKVSEAPEPVPRGCSGHGA-----RTLVSSAAAVSSEGASSAESSSG---SETLSEEGEPSRF 57

  Fly    95 ----VPKRHLSTANLSRIRPQSSYSARVLI--------------------------FDDSDQEAA 129
                .|.|....|..:|: |.:...|||.:                          .::.|:|..
Mouse    58 SCRSQPPRPPGGALGTRL-PAAWAPARVALERGVPTLPLPHPGGAVLPVPQVSSASQEEQDEELD 121

  Fly   130 AAAAALAAASSSCNSSVKSCSGLELLPTSPAKLSIGNDSTNGSSMMRNLNLTKSSS----GGLSG 190
            ...:........|::...:| ||                  |.|:.....|::...    |.|.|
Mouse   122 HILSPPPMPFRKCSNPDVAC-GL------------------GKSLKYKRQLSEDGKQLRRGSLGG 167

  Fly   191 SSSSLHSRGYTALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLTGNYFRHELTAPLP 255
            :.:     |...|...::.|..     ..|.|||||:|||..:||:|||         .|||.|.
Mouse   168 ALT-----GRYLLPNPVAGQAW-----PASAETSNLVRMRSQALGQSAP---------SLTASLE 213

  Fly   256 VQPPGFGASPLGGHNISRSGSCAGIGLAKHHHHHHLH--------------GVVMRGSAGGGAGS 306
            .|||                        |.|.:...|              .:..|||.......
Mouse   214 GQPP------------------------KSHFNSARHRQRLVDPAASKKELSLPRRGSLVDSQKW 254

  Fly   307 GGGSSSGVAHHRLSLVTNSAAVAAAGGSRTHSPYSA----SPVDSPRLNSPMP---FAFAPIKRI 364
            ..........:|.||:.|..:.|.   .|.|||.||    ||.||||..||..   |:||.
Mouse   255 NCLVKRCRTSNRKSLIGNGQSPAL---PRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFAR---- 312

  Fly   365 ASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGA 429
               |....||||||:||||||||||...||.:||.|||||.|:||
Mouse   313 ---RNDRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQL-------------------- 354

  Fly   430 CCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGA 494
                                      |..|.|.:|.      ....:.|...|:
Mouse   355 --------------------------PYQPTPDELH------FLSKHFCTTESI----------- 376

  Fly   495 ANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSP-IVDNEIAVMNTLYKERFPKATQQME 558
                ::.|...::.|          ||||||| ||.||| ..|:||.:||.:|||||||||.|||
Mouse   377 ----ATENRCRNTPM----------RPRSRSL-SPGRSPACCDHEIIMMNHVYKERFPKATAQME 426

  Fly   559 ERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLV 623
            ||||..|............|.  ::.|.|||::|:|||||.||...||||:||:||...|::||.
Mouse   427 ERLKEIITSYSPDHVLPLADG--VLSFTHHQIIELARDCLDKSHQGLITSRYFFELQHKLDKLLQ 489

  Fly   624 ETKEKSPEA-AAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQ 687
            |..::|... .|.:..:::|:|::|:|||||||||||||:|||.||||||||||....||.|||:
Mouse   490 EAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPR 554

  Fly   688 YIIHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAI 752
            |||.:||||:||:.|:.|
Mouse   555 YIISQLGLNKDPLEEMAQ----------------------------------------------- 572

  Fly   753 AMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSA 817
            ..:..|.||      :||               :|:|....|::::
Mouse   573 LGNYDSRTA------ETP---------------EMDESVSSSNTSL------------------- 597

  Fly   818 ATATGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFA 882
                   ..:..|:|:||:.:||||||||||||.|:||.:|||||||||||.|||||||::|.|.
Mouse   598 -------RLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFV 655

  Fly   883 ERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVE 947
            |||||:||:|||||||||||||::|||:||||||||||.||:||:||||.||||.||||||||:|
Mouse   656 ERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALE 720

  Fly   948 YLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTP 1012
            |||:||||||||||||||:|::||||||||||||:||||:.||||||:|:.:.|:|.||||.|||
Mouse   721 YLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTP 785

  Fly  1013 EYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQA 1077
            ||||||||||||||||||||:|||||||||:|||||||:|.||||...::|:|.||:.::.| ..
Mouse   786 EYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAP-PP 849

  Fly  1078 EAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRM 1142
            :|:::|:.||:|||.:|||| .||.|:|:|.:|..:||||||||||||:|||..:|||||||||.
Mouse   850 DAQELITLLLRQNPLERLGT-GGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRS 913

  Fly  1143 DRYNHDLGGEDTDDTDD---TPVFGSFNSYTPQYRKQHYSWSR------HATPTSTDGAKPTGPP 1198
            ::|:| :..|:.|||:|   |.....|:|.:.::.|...|..|      .....|.|..|.|..|
Mouse   914 EKYHH-METEEEDDTNDEDFTVEIRQFSSCSHRFSKVFSSIDRITQNSGEDKDDSEDKTKSTTLP 977

  Fly  1199 PLSSLP-----SRAQETPAATVGAT-------STGALPKLKSGMGSGSGSGSGSGSGSASHDGVV 1251
            ...:|.     |..|:...:....|       |:|.||||                 :.|.||..
Mouse   978 STETLSWSSEYSEMQQLSTSNSSDTESNRCKLSSGLLPKL-----------------AISTDGEQ 1025

  Fly  1252 NKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQQPNPGATQRMQQ 1316
            ::                 .||.:.|....||                     :|.|.:.:..|:
Mouse  1026 DE-----------------AVPCSGDPREEPE---------------------KPVPPSEECTQE 1052

  Fly  1317 RHSMPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRSTPESSQTDSDDFSPQINRKRKGV 1381
            .    |..||..||              .:..|.:|||||            :...|||.:.:.|
Mouse  1053 E----PEVTTPAST--------------ISSSTLSVGSFS------------EHLDQINGRSECV 1087

  Fly  1382 CARDILPRFSISIEDETISAGSSSTENMNLPREQ--SPLALQHQPKSMDGSTSGSSVKHHRSRSI 1444
                                  .||:|.:.|..:  |.:|.|...         |:.|...|..:
Mouse  1088 ----------------------DSTDNSSKPSSEPTSHVARQRLE---------STEKKKISGKV 1121

  Fly  1445 VKSASALGLSLMTSLDNSQLAAQLCGIQSPGGGGN-GSSTASSRDTSPCRELSPLVTNLKPPIII 1508
            .||.||..||||  :.....|....|  ||....: .|..:||||:||.|:.|....:...||:|
Mouse  1122 TKSLSASALSLM--IPGDMFAVSPLG--SPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVI 1182

  Fly  1509 RRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLFHTQ 1573
            ....:.:|||:..||||.||:|.||:||:|..|:|||||::|||:..|||||:|||.|.||.||:
Mouse  1183 HSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPAYQAGLKAGDLITHINGEPVHGLVHTE 1247

  Fly  1574 VLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSLFRR 1638
            |::|||..|..|::..||.|:|||::|..:|:..:.::.     |:.|::|::...:|:.|||::
Mouse  1248 VIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKGRMV-----RRSKKSKKKESLERRRSLFKK 1307

  Fly  1639 I---------SSKRANAEMQQYSAGTSSPTTPSARNLSPLD--SSYHSSCCQSAANSSSQSTSPS 1692
            :         :|:..:...:..|:|.|.|.:|: .:|||..  .||.|:....:..:||||:|||
Mouse  1308 LAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPT-HSLSPRSPTPSYRSTPDFPSGTNSSQSSSPS 1371

  Fly  1693 SSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVPVS 1757
            ||:||:|.||.                                   |:
Mouse  1372 SSAPNSPAGSG-----------------------------------HI----------------- 1384

  Fly  1758 PTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHIPL 1822
                      ||||||||..||                         :.......||||.|.|||
Mouse  1385 ----------RPSTLHGLAPKL-------------------------SGQRYRSGRRKSAGSIPL 1414

  Fly  1823 SPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSY-----SPGSTLPTLQTAVNANTKK 1882
            |||||||||:|.|:||.||||    ||:||..|.:..||::     ||    ||:...:
Mouse  1415 SPLARTPSPTPQPTSPQRSPS----PLLGHSLGNAKITQAFPSKMHSP----PTIVRHI------ 1465

  Fly  1883 AGFARTKSAE-PSSPLLRRALSPDRLHPRSAETKISPLCCS---------PPIKQPTHQRVVTTT 1937
               .|.|||| |.||||:|..|.::|.|.....|  .|.||         ..:::...||.||
Mouse  1466 ---VRPKSAEPPRSPLLKRVQSEEKLSPSYGSDK--KLLCSRKHSLEVTQEEVQREQCQREVT-- 1523

  Fly  1938 WRSTPGGSASGAGGAVLGAPSV---QPLQ---LVPAASEESQRQTAM---------ATVV----- 1982
                    .......|..|||:   :|::   |....|.:..||.::         |.||
Mouse  1524 --------LQSLEENVCDAPSLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKPE 1580

  Fly  1983 -------STTAAGTDPSATAVVTLANCEPLPRIAEEKDSPTSTQDSSSVSEGFMPAIEEFAEGES 2040
                   ...:.|.|..:.|:..|          ||::...           :...:|.....|:
Mouse  1581 EKHESHQKPHSLGGDSESYALFRL----------EEREKKV-----------YSKGLERSGHFEN 1624

  Fly  2041 SSS--PT------QTLEKPTKVKATEQPEMEPAGKSKKVDQGKTTTPGTPKTKPHNSGCKTSMTT 2097
            :|:  |:      .||.|...|:|:|....:.|..|        .|||     .|:.    |:..
Mouse  1625 TSAELPSVGSLLKDTLHKQASVRASEGVTSDGAACS--------LTPG-----EHSQ----SLGD 1672

  Fly  2098 TKPASPSVTI--STAPRKDTSA 2117
            .|.||.|..:  |..|..|..|
Mouse  1673 FKRASASGILHDSVCPISDRPA 1694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	151/362 (42%)
		STKc_MAST	834..1115	CDD:270760	204/280 (73%)
		PDZ_MAST	1502..1594	CDD:467189	48/91 (53%)
Mast4	XP_017171016.1	DUF1908	293..569	CDD:462637	151/362 (42%)
		STKc_MAST	607..886	CDD:270760	204/280 (73%)
		PDZ_MAST4	1176..1270	CDD:467289	49/93 (53%)