DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and Pkcdelta

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	1341	Identity:	302/1341 - (22%)
Similarity:	499/1341 - (37%)	Gaps:	385/1341 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TGPVASSSSSTSSNHSVSAVLGSKISTSTPQKNDEHQEQEFINQSVASEIEAMSISDSA------ 74
            |.|...|:|..|....|.    |...|.|..|.         ||..|.::|:|..|..|
  Fly   683 TTPSIVSTSGKSETQKVP----STPLTPTVVKT---------NQVEAKKVESMDTSSKAPASVIS 734

  Fly    75 -SAESSSGATAT----ATATMSGSPVPKRHLSTANLSR--IRPQSSYSARVLIFDDSDQEAAAAA 132
             :|||....:||    |..||:...:||  |.||..::  |..:::.:...:   ||.:...|..
  Fly   735 KAAESPKLKSATDNNKAKPTMAKKDLPK--LKTAEETKLTITTKATTATPTM---DSPKTPQAKE 794

  Fly   133 AALAAASSSCNSSVKSCSGLEL-----------LPTSP-AKLSIGNDSTNGSSMMRNLNLTKSSS 185
            .......|:..|.:||.:.:.|           .||:| ||:    ::....|..|.:....:..
  Fly   795 ETSQKTESATTSQIKSDTPIALQIKPQEQMKVAAPTTPQAKV----ETPPKDSPTRKIVAPTTPQ 855

  Fly   186 GGLSGSSSSLHSRGY---TALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAP---CLTGN 244
            ..:...:....:|..   |....|:......:..|.:...|:...::...:  |.:|   .:|..
  Fly   856 AKVETPTKDSPTRKIVTPTTPQAKVETPTKDSPTRKIVTPTTPQAKVETPT--KDSPTRKIVTPT 918

  Fly   245 YFRHELTAP----------LPVQPPGFGA----SPL----------GGHNISRSGSCA-GIGLAK 284
            ..:.::..|          .|..|....|    |||          ...:.|:|...| ...:||
  Fly   919 TPQAKVETPTKDSPTRKIATPTTPQAKAAASTTSPLTTPQKTPQVKAATDESKSTPAAPKTTMAK 983

  Fly   285 HHHHHHLHGVVMRGSAGGGAGS----GGGSSSGVAHHRLSLVTNSAAVAAAGGSRTHSPYSA--- 342
                  :....|.|:....||.    .|...||          |:.|:..|..:..::|.:|
  Fly   984 ------ISMTTMAGTTVAEAGKTISPKGLKQSG----------NAVAMPTATPTTPNTPTTATGK 1032

  Fly   343 ---SPVDSPRLNSPMPFAFAPIKRIASCRGV---------------------------------- 370
               :....|::||..| |.:|.::.|:...|
  Fly  1033 SKLNETAGPKINSGQP-AKSPEQQQATAAAVETKINKTTDKEQQQQQQQQQQQQAQQQQQQLIDT 1096

  Fly   371 ----------------VADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQE 419
                            .|:....|....|::....:.|.:|:..:.::          .|.....
  Fly  1097 AATLVPQTETKTKLTEAAEPTGKSKVQSPNTTKPKSAGKTNVGKKKAA----------TPAAAAA 1151

  Fly   420 ADAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQLTP---------QPPKPTQLQPQK------- 468
            |.|||..|.|...|           .:.|:|:..:||         .|.|..:..|.|
  Fly  1152 AAAAAAPAAATATE-----------AVTALSESNVTPINADQFITLAPTKAAKTSPNKQQALQLQ 1205

  Fly   469 ---------------------------------SMTAACVNCCAELSV-TCGGQQAGGGAANGGS 499
                                             ::..|.||..|...| :.....|...||:..:
  Fly  1206 QQHEEQQRQQQQQATNASSPAATGDATTTPTTITIGVAAVNVAAVAVVASAAAAAATDAAADATT 1270

  Fly   500 SANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLKLF 564
            |.:|:.|....||..:|.:  ....:|:...|.  ||.|:       .:..|.:.:..:|.
  Fly  1271 SLSSNNSCGEGVGNNLSKF--ATVSNLAQCLRD--VDAEL-------DDYIPSSAENSQED---- 1320

  Fly   565 INENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKS 629
             :::......|..|....|           ..|.:              ||.::::.|  .|||.
  Fly  1321 -DDDDDDGSGSSSDDYSSV-----------DGCAN--------------LSASMKKKL--RKEKK 1357

  Fly   630 PEAAAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLG 694
            .:.|               :.|...|...|||            |.|    ||.|.......|..
  Fly  1358 KQKA---------------KAAAAAEAKRFDP------------HKK----IKIDTTNKCYVKEE 1391

  Fly   695 LNRDPIAELQQELRETQQMC-SEQVTVDADPLH--PGGSLLLNSPLTSAAKQLSSLA-------L 749
            ..|.|:....:.|.:.:::. |::.|.|.....  .||||..:|...|..::.||.:       |
  Fly  1392 APRYPLVATPRPLWKREKIVYSDENTDDESGSEEGSGGSLDEDSDDESGGEECSSTSSSASSEDL 1456

  Fly   750 DAIAM--DSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSS--------- 803
            ||:||  .:||..||         ...|::.|.......::....||.|  |||:|
  Fly  1457 DAVAMVTKAGSSNAT---------TVLDSSNSSGSNAGTLSVPSAGSGS--GGGASTSSSPSIIR 1510

  Fly   804 -SKVAGAEGITGGSAATA---------TGSGAQQ------PSP--------QENDFDIVKLISNG 844
             |..:...|..||:|.::         |.|..|:      |:.        ..:||..:.::..|
  Fly  1511 MSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKG 1575

  Fly   845 AYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSF-ADNPFVVSMYCSFETKKHL 908
            ::|.|.|.:.:.|...:|:|.:.|:.::..:.|:....||.:|:. ..:|::..::|:|:|:.||
  Fly  1576 SFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHL 1640

  Fly   909 CLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIK 973
            ..||||:.|||....::..|....:.||||.||.:..:::||..||::||||.||:|:...||::
  Fly  1641 FFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVR 1705

  Fly   974 LTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIIL 1038
            :.|||:.|:.:          |:|.....|.     |||:|:|||:|..:.|.:.|||||.|::|
  Fly  1706 IADFGMCKLQI----------YLDKTADSFC-----GTPDYMAPEIIKGEKYNQNVDWWSFGVLL 1755

  Fly  1039 YEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPV--QAEAKDIISQLLQQNPRDRLGTQ-SG 1100
            ||.|||..||.|...:||| .::.::|.|     :||  .|||..|:..||:::...|:|:| |.
  Fly  1756 YEMLIGQSPFSGCDEDELF-WSICNEIPW-----FPVYISAEATGILKGLLEKDYTKRIGSQYSP 1814

  Fly  1101 ALEMKEHEYFLGMDWNSLLRQKAE--FVPQLSHDDDTSYFD 1139
            |.::.:|.:|..:||..|.:::.|  |.||:.|..||.|||
  Fly  1815 AGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPLDTQYFD 1855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	74/457 (16%)
		STKc_MAST	834..1115	CDD:270760	98/284 (35%)
		S_TKc	835..1110	CDD:214567	96/278 (35%)
		PDZ_signaling	1506..1587	CDD:238492
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	96/278 (35%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	109/307 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100