Protein Alignment dop and Mast2

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: XP_017448928.2
• Gene: Mast2 / 313819
• RGDID: 1304573
• Length: 1796
• Species: Rattus norvegicus
• Alignment Length: 2128
• Identity: 746/2128 - (35%)
• Similarity: 986/2128 - (46%)
• Gaps: 651/2128 - (30%)

  Fly   122 DDSDQEAAAAAAALAAASSSCNSSVKSCSGLELLPTSPAKLSIGNDSTNGSSMMRNLNLTKSSSG 186
            |..:|:..:..:.|.....| |..:.|       ||..|||.  ...:.....:|..:|..|.||
  Rat    56 DSREQDMVSGLSPLLFRKLS-NPDIFS-------PTGKAKLQ--RQLSQDDCKLRRGSLASSLSG 110

  Fly   187 -GLSGSSSSLHSRGYTALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLTGNYFRHEL 250
             .|...|||:||.     :.::::|.        :||.|||:|||:.|||:|||.||...  .||
  Rat   111 KQLLPLSSSVHSS-----VGQVTWQS--------TGEASNLVRMRNQSLGQSAPSLTAGL--KEL 160

  Fly   251 TAPLPVQPPGFGASPLGGHNISRSGS-CAGIGLAKHHHHHHLHGVVMRGSAGGGAGSGGGSSSGV 314
            :.|                   |.|| |.
  Rat   161 SLP-------------------RRGSFCR------------------------------------ 170

  Fly   315 AHHRLSLVTNSAAVAAAGGSRTHSPYSA----SPVDSPR---LNSPMPFAFAPIKRIASCRGVVA 372
            ..:|.||:..|:.....  .|.|||...    ||:||||   .|:|..|:|.| .|....|....
  Rat   171 TSNRKSLIVTSSTSPTL--PRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVP-ARSHGHRADRT 232

  Fly   373 DGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAEHLKQ 437
            ||||||:||||||||||...||.:||.|||||.|:||     |....||..             .
  Rat   233 DGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQL-----PFQPTADEL-------------H 279

  Fly   438 HCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSAN 502
            ...||.:                 |:..|.:.
  Rat   280 FLTKHFS-----------------TENVPDEE--------------------------------- 294

  Fly   503 SSGSSAMQVGGRMSPYFRPRSRSLSSPSRSPI-VDNEIAVMNTLYKERFPKATQQMEERLKLFIN 566
                      ||.||..||||||| ||.|||: .|:||.:||.:|||||||||.||||||..||
  Rat   295 ----------GRQSPAMRPRSRSL-SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFI- 347

  Fly   567 ENKSAACNSFRDSQPI----VRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKE 627
                 :||:.....|:    :.|:||||:|||||||.||.:.||||.|||||.||||:||.:..|
  Rat   348 -----SCNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSHYFYELQENLEKLLQDAHE 407

  Fly   628 KSPEA-AAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIH 691
            :|..: .|.:..::|||::||:|||||||||||||:|||.||||||||||....||.|||:||:.
  Rat   408 RSESSDVAFVIQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGHGIKCDIPRYIVS 472

  Fly   692 KLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDS 756
            :|||.|||:.|:                                      .||||       .||
  Rat   473 QLGLTRDPLEEM--------------------------------------VQLSS-------YDS 492

  Fly   757 GSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATAT 821
                      |.|| .|.|                                           :..
  Rat   493 ----------PDTP-ETDD-------------------------------------------SVE 503

  Fly   822 GSGAQQPS---PQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAE 883
            |.||.|||   |.|.||:.:|||||||||||:||:||:||||||||||||.|||||||::|.|.|
  Rat   504 GRGASQPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVE 568

  Fly   884 RDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEY 948
            ||||:||:|||||||:||||||:|||:||||||||||.|||||||.||.||.|.||||||||:||
  Rat   569 RDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEY 633

  Fly   949 LHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPE 1013
            ||:||||||||||||||||::||||||||||||:|||||.||||||:|:.:.|:|.||||.||||
  Rat   634 LHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPE 698

  Fly  1014 YIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAE 1078
            |||||||||||||||||||:|||||||||:|||||||:|.||||...::|:|.||:.:| .:..:
  Rat   699 YIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDD-ALPPD 762

  Fly  1079 AKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMD 1143
            |:|:.|:||.|||.:|||| |.|.|:|:|.:|:|:||..||||||||:|||..:|||||||||.:
  Rat   763 AQDLTSKLLHQNPLERLGT-SSAYEVKQHPFFMGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSE 826

  Fly  1144 RYNHDLGGEDTDDTDDTPVFG-----SFNSYTPQYRKQHYSWSR------HATPTSTDGAKPTGP 1197
            ||:|    .|::|.::....|     .|:|.:|::.|.:.|..|      |.||          |
  Rat   827 RYHH----VDSEDEEEVSEDGCLEIRQFSSCSPRFSKVYSSMERLSLLEGHRTP----------P 877

  Fly  1198 PPLSSLPSRAQETPAATVGATSTGALPKLKSGMGSGSGSGSGSGSGSASHDGVVNKFLNTPQL-- 1260
            |...||....::.                ..|:....|.......||             |::
  Rat   878 PTKRSLSEEKEDH----------------SDGLAGLKGRDRSWVIGS-------------PEILR 913

  Fly  1261 RKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQQPNPGATQRMQQRHSMPPNTT 1325
            ::|.:|.|     |..::|..|.:                            .::.|..:|....
  Rat   914 KRLSVSES-----SHTESDSSPPM----------------------------TVRHRSGLPDVPR 945

  Fly  1326 TIISTPATPPPTQTQATMAATPPTATVGSFSRSTPE---SSQTDSDDFSP-QINRKRKGVCARDI 1386
            ....|.:||...|.:.....|||:.. || ||..||   ..|...|:..| |.:|....:
  Rat   946 CAEETSSTPRKQQQEGIWVLTPPSGE-GS-SRPVPERPLERQLKLDEEPPGQSSRSCPAM----- 1003

  Fly  1387 LPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQPKSMDGSTSGSSVKHHRSR---SIVKSA 1448
                      ||...|:.........:..|.||::   ::.....||.|::...:|   .::|||
  Rat  1004 ----------ETRGRGTPQLAEEATAKAISDLAVR---RARHRLLSGDSIEKRTTRPVNKVIKSA 1055

  Fly  1449 SALGLSLMTSLDNSQLAAQLCG-IQSPGGGGNGSSTASSRDTSPCRELSPLVTNLKPPIIIRRGP 1512
            ||..|||:...::     ..|. :.||....:.||..||||:||.|:..|.:.:|:|||||.|..
  Rat  1056 SATALSLLIPSEH-----HACSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSLRPPIIIHRAG 1115

  Fly  1513 RGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLFHTQVLQL 1577
            :.:|||:..||||.||:|.||:||:|..|::|.||.|||||..|||||||||.|.||.||:|::|
  Rat  1116 KKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVEL 1180

  Fly  1578 LLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSLFRRI--- 1639
            :|..|..|::..||||:|||:.|..::...::|:|::.   ::.:.|...:.:::.||||:|
  Rat  1181 VLKSGNKVSISTTPLENTSIKVGPARKGSSKAKMARRS---KRSRGKDGQESRKRNSLFRKITKQ 1242

  Fly  1640 -----SSKRANAEMQQYSAGTSSPTTPS-ARNLSPLD--SSYH--SSCCQSAANSSSQSTSPSSS 1694
                 :|:..::..:..|:|.|.|.:|: :.:|||..  ..|.  .....|...:||||:|||||
  Rat  1243 ASLLHTSRSLSSLNRSLSSGESGPCSPTHSHSLSPRSPPQGYRVAPDTVHSVGGNSSQSSSPSSS 1307

  Fly  1695 SPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVPVSPT 1759
            .|::|.||.
  Rat  1308 VPSSPAGSG-------------------------------------------------------- 1316

  Fly  1760 GVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHIPLSP 1824
                  :.|||:||||..||..         ...:|                 ||||.|.|||||
  Rat  1317 ------HTRPSSLHGLAPKLQR---------QYRSP-----------------RRKSAGSIPLSP 1349

  Fly  1825 LARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSYSP--GSTLPTLQTAVNANTKKAGFAR 1887
            ||.||||....:||.||||||:    ||...:..|....||  |..|                :|
  Rat  1350 LAHTPSPPAAAASPQRSPSPLS----GHGSQSFPTKLHLSPPLGRQL----------------SR 1394

  Fly  1888 TKSAE-PSSPLLRRALSPDRLHP--RSAETKISPLCCSPPIKQPTHQRVVTTTWRSTPGGSASGA 1949
            .|||| |.||||:|..|.::|..  .:||.|::|        ...|.       ...|.|...
  Rat  1395 PKSAEPPRSPLLKRVQSAEKLAAALAAAEKKLAP--------SRKHS-------LDLPHGELK-- 1442

  Fly  1950 GGAVLGAPSVQPLQLVPAASEESQRQTAMATVVSTTAAGTDPSATAVVTLANCEPLPRIAEEKDS 2014
                               .|.:.|:.....||.|.:           .|:...|||.....:.:
  Rat  1443 -------------------KELTPREANPLEVVGTRS-----------VLSGKGPLPGKGVLQPA 1477

  Fly  2015 P-----TSTQDSSSVSEGFMPAIEEFAEGESSSSPTQTLEKPTKVKATEQPEMEP---------- 2064
            |     |..||.:...|...   ::.|..|..||...|.|:|...:||::|.:.|
  Rat  1478 PSRALGTLRQDRAERRESLQ---KQEAIREVDSSEDDTDEEPENSQATQEPRLSPHPEASQNLLP 1539

  Fly  2065 --AGKSKKVDQ-------------------GKTTTPGTPKTK---PH------NSGCKTSMTTTK 2099
              :|:.::.|.                   .:...||..:.|   |.      ||....|::.:.
  Rat  1540 KGSGEGREEDTFLHRDLKNRGPVLSGLLTGNRIEVPGLSQRKLWRPQAFEEATNSLQAPSLSRSG 1604

  Fly  2100 PASPS----------------VTI--STAPRKDTSAVTGGGSSGSGGS 2129
            |.||:                .|:  |::....||......:||..|:
  Rat  1605 PTSPTPSEGCWEARQLHTQALATLHPSSSELTPTSCSAATSTSGKPGT 1652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	164/366 (45%)
		STKc_MAST	834..1115	CDD:270760	209/280 (75%)
		PDZ_MAST	1502..1594	CDD:467189	53/91 (58%)
Mast2	XP_017448928.2	DUF1908	202..483	CDD:462637	164/366 (45%)
		STKc_MAST	519..798	CDD:270760	209/280 (75%)
		PDZ_MAST2	1105..1197	CDD:467287	53/91 (58%)