DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and Sgk1

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	XP_006227785.1	Gene:	Sgk1 / 29517	RGDID:	3668	Length:	525	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	138/498 - (27%)
Similarity:	222/498 - (44%)	Gaps:	125/498 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   646 IISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYI-IHKLGLNRDPIAELQQELRE 709
            |:::|         ||:.|:                .:|.|.:: ..::|||     :..|:|..
  Rat   104 ILTKP---------DPRTFW----------------TSDDPAFMKQRRMGLN-----DFIQKLAN 138

  Fly   710 TQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATC 774
            ....|.          ||.    :.|.|..:..|...|.           .|.|..||
  Rat   139 NSYACK----------HPE----VQSYLKISQPQEPELM-----------NANPSPPP------- 171

  Fly   775 DTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPSPQENDFDIVK 839
              :||     .|:|  .|.||:                               |..:.:||..:|
  Rat   172 --SPS-----QQIN--LGPSSN-------------------------------PHAKPSDFHFLK 196

  Fly   840 LISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDI-LSFADNPFVVSMYCSFE 903
            :|..|::|.|.|.:||.....:|:|.:.|..::.:.:.:.:.:||:: |....:||:|.::.||:
  Rat   197 VIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQ 261

  Fly   904 TKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITA 968
            |...|..|::|:.||:....|:.........||||.||...|:.||||..||:|||||:|:|:.:
  Rat   262 TADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDS 326

  Fly   969 LGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWS 1033
            .|||.||||||.|..:....|          |..|.     |||||:||||:.:|.|.:.||||.
  Rat   327 QGHIVLTDFGLCKENIEHNGT----------TSTFC-----GTPEYLAPEVLHKQPYDRTVDWWC 376

  Fly  1034 MGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQ 1098
            :|.:|||.|.|..||:...|.|::.:.:|..::...:    :...|:.::..|||::...|||.:
  Rat   377 LGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN----ITNSARHLLEGLLQKDRTKRLGAK 437

  Fly  1099 SGALEMKEHEYFLGMDWNSLLRQK--AEFVPQLSHDDDTSYFD 1139
            ...:|:|.|.:|..::|:.|:.:|  ..|.|.:|...|..:||
  Rat   438 DDFMEIKSHIFFSLINWDDLINKKITPPFNPNVSGPSDLRHFD 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	10/56 (18%)
		STKc_MAST	834..1115	CDD:270760	98/281 (35%)
		S_TKc	835..1110	CDD:214567	96/275 (35%)
		PDZ_signaling	1506..1587	CDD:238492
Sgk1	XP_006227785.1	S_TKc	192..449	CDD:214567	96/275 (35%)
Sgk1	XP_006227785.1	STKc_SGK	196..518	CDD:270727	105/304 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840