Protein Alignment dop and LATS2

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Alignment Length: 1262
• Identity: 301/1262 - (23%)
• Similarity: 447/1262 - (35%)
• Gaps: 358/1262 - (28%)

  Fly   110 PQSSYSARVLIFDDSDQEAAAAAAALAAASSSCNSSVKSCSGLELLPTS----PAKLSIGNDSTN 170
            |.::||.      :|.|........|...|.|      |..||...|.|    .||:....|:|.
Human     7 PATTYSG------NSRQRLQEIREGLKQPSKS------SVQGLPAGPNSDTSLDAKVLGSKDATR 59

  Fly   171 GSSMMRNLNLTKSSSGGLSGSSSSLHSRGYTALLRKISYQQHTNSLRAVSGE--TSNLLRMRHSS 233
            ....||                ::.....|...||:|.|     ||...:.|  ||....:....
Human    60 QQQQMR----------------ATPKFGPYQKALREIRY-----SLLPFANESGTSAAAEVNRQM 103

  Fly   234 LGK--SAPC---LTGNYFR------------------------HELTAPLPVQPPGFGASPLGGH 269
            |.:  :|.|   :.|...:                        .::...:....||.|..|.
Human   104 LQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPT--- 165

  Fly   270 NISRSGSCAGIGLAKHHHHHHLHGVVMRGSAGGGAGS---------------GGGSSSGVAH-HR 318
            .::|..|..|.| .....:|.|.|....|.:.|..|.               .|....|..| |:
Human   166 PVTRRPSFEGTG-DSFASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQ 229

  Fly   319 LSLVTNSAAVAAAGGSRTHSPYSASPVDSPRLNSP-MPFAFAPIKRIASCRGVVADGRRWSVASL 382
            .......|:|.|||   .|.|...:....|.|..| .|..:. ::|..|.:..... .....|||
Human   230 HPPKGYGASVEAAG---AHFPLQGAHYGRPHLLVPGEPLGYG-VQRSPSFQSKTPP-ETGGYASL 289

  Fly   383 PSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAE-HLKQHCPKHCALL 446
            |:.|.|..||:           ||     ..||         .|||..... |.||..|....|.
Human   290 PTKGQGGPPGA-----------GL-----AFPP---------PAAGLYVPHPHHKQAGPVAHQLH 329

  Fly   447 LAVSQKQL--TPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAM 509
            :..|:.|:  :..||:......:.|:.....    |||.|         :.....:|..:...::
Human   330 VLGSRSQVFASDSPPQSLLTPSRNSLNVDLY----ELSST---------SVQQWPAATLARRDSL 381

  Fly   510 QVGGRMSPYFRPRSRSLSSPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLKLFINENKSAACN 574
            |..|..:|   ||:.....|. .|:                |..|                   |
Human   382 QKPGLEAP---PRAHVAFRPD-CPV----------------PSRT-------------------N 407

  Fly   575 SFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKSPEAAAE---- 635
            ||...||                                             ...|...||
Human   408 SFNSHQP---------------------------------------------RPGPPGKAEPSLP 427

  Fly   636 -LNGVIKKLLLIISRPARLLECLEFDPQEFY-------------------------ELLEAAEGH 674
             .|.|.......|..|.:.:..|..:||...                         |.|:|.|.|
Human   428 APNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAPAAEGLDAKEEH 492

  Fly   675 AKAM--------------PVIKADIPQYIIHKLGLNRDPIAELQQELRETQQMCS--EQVTVDAD 723
            |.|:              |..:...|.|..|.|       ...:.|..:...:|:  || ::.|.
Human   493 ALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLL-------LRSKSEQYDLDSLCAGMEQ-SLRAG 549

  Fly   724 PLHPGGSLLLNSPLTSA--------AKQLSSLAL-------DAIAMDSGSGTATP-------QQP 766
            |..|.|.   :....||        .||:.:..:       |....:|...:.:|       :|.
Human   550 PNEPEGG---DKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQH 611

  Fly   767 PQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPSPQ 831
            .:..:.|.....:..|.:.| ...|.|...|........:...|         :..:..::....
Human   612 VENVIKTYQQKVNRRLQLEQ-EMAKAGLCEAEQEQMRKILYQKE---------SNYNRLKRAKMD 666

  Fly   832 ENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVV 896
            ::.|..:|.:..||:|.|.|.....|...:|||.:.|.:::.||||..|.||||||:.|||.:||
Human   667 KSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVV 731

  Fly   897 SMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKP 961
            .:|.||:.|..|..||:|:.|||..:||..:...|..:||||.||..||:|.:|..|.:|||:||
Human   732 KLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKP 796

  Fly   962 DNLLITALGHIKLTDFGLSKMGLMSLATNLYE--GYIDSETRQFSD------------------- 1005
            ||:||...||||||||||......:..:..|:  .::..::.:.||
Human   797 DNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQ 861

  Fly  1006 ---KQ--------VYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAH 1059
               ||        :.|||.||||||:||:||.:..||||:|:||:|.|:|..||...|..|....
Human   862 RARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLK 926

  Fly  1060 TVNDDIEWPDSEDWPVQA----EAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLR 1120
            .:|    |.::...|.|.    ||:|:|::|. .:...||| ::||.::|.|.:|..:|::|.:|
Human   927 VIN----WENTLHIPAQVKLSPEARDLITKLC-CSADHRLG-RNGADDLKAHPFFSAIDFSSDIR 985

  Fly  1121 -QKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDTDDTPVFGSFNSYTPQYRKQHYSWSRHA 1184
             |.|.:||.:||..|||.||...:....:...|.:....||  ..|.|:..|::....:::.|.
Human   986 KQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDT--LTSPNNKHPEHAFYEFTFRRF- 1047

  Fly  1185 TPTSTDGAKP-TGPPPLSSLPSRAQET 1210
               ..|...| ..|.|..:..|:|:.:
Human  1048 ---FDDNGYPFRCPKPSGAEASQAESS 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	72/405 (18%)
		STKc_MAST	834..1115	CDD:270760	121/316 (38%)
		PDZ_MAST	1502..1594	CDD:467189
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581	4/39 (10%)
		PHA03247	<143..521	CDD:223021	94/508 (19%)
		MobB_LATS2	587..669	CDD:439272	11/91 (12%)
		STKc_LATS2	668..1048	CDD:173715	142/391 (36%)