Protein Alignment dop and MAST2

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: XP_011539361.1
• Gene: MAST2 / 23139
• HGNCID: 19035
• Length: 1870
• Species: Homo sapiens
• Alignment Length: 2098
• Identity: 753/2098 - (35%)
• Similarity: 994/2098 - (47%)
• Gaps: 605/2098 - (28%)

  Fly   168 STNGSSMMRNL----------NLTKSSSG-GLSGSSSSLHSRGYTALLRKISYQQHTNSLRAVSG 221
            ||....:.|.|          ||..|.|| .|...|||:||.     :.::::|.        ||
Human    81 STGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSS-----VGQVTWQS--------SG 132

  Fly   222 ETSNLLRMRHSSLGKSAPCLTGNYFRHELTAP--------------------LPVQPPGFGASPL 266
            |.|||:|||:.|||:|||.||...  .||:.|                    .|...|....:
Human   133 EASNLVRMRNQSLGQSAPSLTAGL--KELSLPRRGSLISTLCRGAEVNQHMFSPTSAPALFLT-- 193

  Fly   267 GGHNISRSGSCA------GIGLAKHHHHHHLHGVVMRGSAGGGAGSGGGSSSGVAHHRLSLVTNS 325
               .:..|..||      .|.|....|          .|.|....|.....|....:|.||:..|
Human   194 ---KVPFSADCALATSPLAIFLNPRAH----------SSPGTPCSSRPLPWSCRTSNRKSLIVTS 245

  Fly   326 AAVAAAGGSRTHSPYSA----SPVDSPR---LNSPMPFAFAPIKRIASCRGVVADGRRWSVASLP 383
            :.....  .|.|||...    ||:||||   .|:|..|:|.| .|..|.|....||||||:||||
Human   246 STSPTL--PRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVP-ARSHSHRADRTDGRRWSLASLP 307

  Fly   384 SSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLA 448
            ||||||...||.:||.|||||.|:||
Human   308 SSGYGTNTPSSTVSSSCSSQEKLHQL--------------------------------------- 333

  Fly   449 VSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGG 513
                     |.:||               ..||...               :.:.|..|.....|
Human   334 ---------PFQPT---------------ADELHFL---------------TKHFSTESVPDEEG 359

  Fly   514 RMSPYFRPRSRSLSSPSRSPI-VDNEIAVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFR 577
            |.||..||||||| ||.|||: .|:||.:||.:|||||||||.||||||..||:.|...:.....
Human   360 RQSPAMRPRSRSL-SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLA 423

  Fly   578 DSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKSPEA-AAELNGVIK 641
            |.  .:.|:||||:|||||||.||.:.||||||||||.:|||:||.:..|:|..: .|.:..::|
Human   424 DG--ALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVK 486

  Fly   642 KLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAELQQE 706
            ||::||:|||||||||||||:|||.||||||||||....||.|||:||:.:|||.|||:.|:
Human   487 KLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEM--- 548

  Fly   707 LRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPV 771
                                               .||||       .||          |.||
Human   549 -----------------------------------AQLSS-------CDS----------PDTP- 560

  Fly   772 ATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPS---PQEN 833
               :|..|.                                        .|.||..||   |.|.
Human   561 ---ETDDSI----------------------------------------EGHGASLPSKKTPSEE 582

  Fly   834 DFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSM 898
            ||:.:|||||||||||:||:||:||||||||||||.|||||||::|.|.|||||:||:|||||||
Human   583 DFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSM 647

  Fly   899 YCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDN 963
            :|||:||:|||:||||||||||.|||||||.||.||.|.||||||||:||||:||||||||||||
Human   648 FCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDN 712

  Fly   964 LLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKP 1028
            ||||::||||||||||||:|||||.||||||:|:.:.|:|.||||.|||||||||||||||||||
Human   713 LLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKP 777

  Fly  1029 VDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRD 1093
            ||||:|||||||||:|||||||:|.||||...::|:|.||:.:: .:..:|:|:.|:||.|||.:
Human   778 VDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDE-ALPPDAQDLTSKLLHQNPLE 841

  Fly  1094 RLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDTD 1158
            ||||.| |.|:|:|.:|.|:||..||||||||:|||..:|||||||||.:||:|    .|::|.:
Human   842 RLGTGS-AYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHH----MDSEDEE 901

  Fly  1159 DTPVFG-----SFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGAT 1218
            :....|     .|:|.:|::.|.:.|..|                 ||.|..|  .||
Human   902 EVSEDGCLEIRQFSSCSPRFNKVYSSMER-----------------LSLLEER--RTP------- 940

  Fly  1219 STGALPKLKSGMGSGSGSGSGSGSGSASHDGVVNKFLNTPQL--RKLDLSSSCLKVPSTPDADYL 1281
                 |..|..:.......|...:|....|.  :..:.:|::  ::|.:|.|     |..::|
Human   941 -----PPTKRSLSEEKEDHSDGLAGLKGRDR--SWVIGSPEILRKRLSVSES-----SHTESD-- 991

  Fly  1282 PELLHNVTIGNDAELRMLKHYLQQPNPGATQRMQQRHSMPPNT-----TTIISTPATPP-PTQTQ 1340
                                                 |.||.|     :.::..|..|. |.:..
Human   992 -------------------------------------SSPPMTVRRRCSGLLDAPRFPEGPEEAS 1019

  Fly  1341 ATMAATPPTATVGSFSRSTPESSQTDSDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSS 1405
            :|:...|..    .....||.|.:..|...:.....:|         |:    :::|.:...|.|
Human  1020 STLRRQPQE----GIWVLTPPSGEGVSGPVTEHSGEQR---------PK----LDEEAVGRSSGS 1067

  Fly  1406 TENMNL-PREQSPLALQHQPKSMDGST-----------------SGSSVKHHRSR---SIVKSAS 1449
            :..|.. .|..|.||        :|:|                 ||.|.:...:|   .::||||
Human  1068 SPAMETRGRGTSQLA--------EGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSAS 1124

  Fly  1450 ALGLSLMTSLDNSQLAAQLCG-IQSPGGGGNGSSTASSRDTSPCRELSPLVTNLKPPIIIRRGPR 1513
            |..|||:...::     ..|. :.||....:.||..||||:||.|:..|.:.:::|||||.|..:
Human  1125 ATALSLLIPSEH-----HTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRPPIIIHRAGK 1184

  Fly  1514 GFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLFHTQVLQLL 1578
            .:|||:..||||.||:|.||:||:|..|::|.||.|||||..|||||||||.|.||.||:|::|:
Human  1185 KYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELI 1249

  Fly  1579 LSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSLFRRI---- 1639
            |..|..|.:..||||:|||:.|..::...::|:|::.   ::.:.|...:.::::||||:|
Human  1250 LKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRS---KRSRGKDGQESRKRSSLFRKITKQA 1311

  Fly  1640 ----SSKRANAEMQQYSAGTSSPTTPS-ARNLSPLD--SSYH--SSCCQSAANSSSQSTSPSSSS 1695
                :|:..::..:..|:|.|.|.:|: :.:|||..  ..|.  .....|...:||||:|||||.
Human  1312 SLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSV 1376

  Fly  1696 PNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVPVSPTG 1760
            |::|.||.
Human  1377 PSSPAGSG--------------------------------------------------------- 1384

  Fly  1761 VVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHIPLSPL 1825
                 :.|||:||||..||..         ...:|                 ||||.|.||||||
Human  1385 -----HTRPSSLHGLAPKLQR---------QYRSP-----------------RRKSAGSIPLSPL 1418

  Fly  1826 ARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSYSP--GSTLPTLQTAVNANTKKAGFART 1888
            |.||||.|..:||.||||||:    ||...|..|....||  |..|                :|.
Human  1419 AHTPSPPPPTASPQRSPSPLS----GHVAQAFPTKLHLSPPLGRQL----------------SRP 1463

  Fly  1889 KSAE-PSSPLLRRALSPDRLHP--RSAETKI------------SPLCCSPPIKQPTHQRVVTTTW 1938
            |||| |.||||:|..|.::|..  .::|.|:            |.|....|.::.:...||..
Human  1464 KSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGA-- 1526

  Fly  1939 RSTPGGSASGAGGAVL-GAPS--VQPLQLVPAASEES-QRQTAMATVVST---TAAGTDPSATA- 1995
            ||...|..:..|..|| .|||  :..|:...|...|| |:|.|:..|.|:   |..|.:.|..|
Human  1527 RSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQ 1591

  Fly  1996 VVTLANCEPLPRIAEE----------KDSPTSTQDSSSVSEGFMPAIEEFAEG--------ESSS 2042
            .::||   |.|.:::.          ::.|..::|..|:.    |.:.....|        ||.|
Human  1592 ELSLA---PHPEVSQSVAPKGAGESGEEDPFPSRDPRSLG----PMVPSLLTGITLGPPRMESPS 1649

  Fly  2043 SPTQTLEKPTKVKATEQPEMEPAGKSKKVDQGKTTTPGTPKTKPHNSGC-------KTSMTTTKP 2100
            .|.:.|..|..::  |......||.:  :.|...|.|..|:      ||       ..::|...|
Human  1650 GPHRRLGSPQAIE--EAASSSSAGPN--LGQSGATDPIPPE------GCWKAQHLHTQALTALSP 1704

  Fly  2101 ASPSV--TISTAPRKDTS 2116
            ::..:  |.|.:|...||
Human  1705 STSGLTPTSSCSPPSSTS 1722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	164/362 (45%)
		STKc_MAST	834..1115	CDD:270760	207/280 (74%)
		PDZ_MAST	1502..1594	CDD:467189	52/91 (57%)
MAST2	XP_011539361.1	DUF1908	266..547	CDD:462637	164/362 (45%)
		STKc_MAST	583..862	CDD:270760	207/280 (74%)
		PDZ_MAST2	1173..1265	CDD:467287	52/91 (57%)