DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and MAST1

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	NP_055790.1	Gene:	MAST1 / 22983	HGNCID:	19034	Length:	1570	Species:	Homo sapiens

Alignment Length:	1974	Identity:	714/1974 - (36%)
Similarity:	947/1974 - (47%)	Gaps:	587/1974 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 GGS-----SSGVAHHRLSLVTNSAAVAAAGGSRTHSP----YSASPVDSPR---LNSPMPFAFAP 360
            |||     .|....:|.||:..|.:...   .|.|||    ..:||:||||   .|:|..|:||.
Human    19 GGSMFRRTKSCRTSNRKSLILTSTSPTL---PRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSFAS 80

  Fly   361 IKRIASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAV 425
            .:|        |||||||:||||||||||...||.:||.|||||.|:||.:.  |.|.|
Human    81 SRR--------ADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQ--PTVDE------ 129

  Fly   426 AAGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQA 490
                  ...|.:|
Human   130 ------LHFLSKH---------------------------------------------------- 136

  Fly   491 GGGAANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSP-IVDNEIAVMNTLYKERFPKAT 554
                      ..|:.|...:.|||.||..||||||| ||.||| ..||||.:||.:|||||||||
Human   137 ----------FGSTESITDEDGGRRSPAVRPRSRSL-SPGRSPSSYDNEIVMMNHVYKERFPKAT 190

  Fly   555 QQMEERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLE 619
            .||||:|:.|....:..:.....|.  ::.|:|||::|:|||||.||...|||:.|||||.||||
Human   191 AQMEEKLRDFTRAYEPDSVLPLADG--VLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLE 253

  Fly   620 RLLVETKEKSPE-AAAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKA 683
            :||.:..|:|.. ..|.:..::||||:||||||||||||||:|:|||.||||||||||...::|.
Human   254 KLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKT 318

  Fly   684 DIPQYIIHKLGLNRDP---IAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLS 745
            |||:|||.:|||.|||   :..|:::
Human   319 DIPRYIIRQLGLTRDPFPDVVHLEEQ--------------------------------------- 344

  Fly   746 SLALDAIAMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAE 810
                     ||| |:.||:|                   ..::|           |.|||
Human   345 ---------DSG-GSNTPEQ-------------------DDLSE-----------GRSSK----- 364

  Fly   811 GITGGSAATATGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRN 875
                          |::| |.|||||.:||||||||||||||:|:.||||||||||||.||||||
Human   365 --------------AKKP-PGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRN 414

  Fly   876 QVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFA 940
            |::|.|.|||||:||:|||||.|:|||||::|||:||||||||||.|||||||.||.:|||.|||
Human   415 QIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFA 479

  Fly   941 ETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSD 1005
            |||||:||||:||||||||||||||||::||||||||||||||||||.||||||:|:.:.|:|.|
Human   480 ETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLD 544

  Fly  1006 KQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDS 1070
            |||.|||||||||||||||||||||||:|||||||||:|||||||:|.||||...::|||.||:.
Human   545 KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEG 609

  Fly  1071 EDWPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDT 1135
            :: .:..||:.:||.|||.||..|||. .||.|:|:|.:|..:||..||||||||:|.|..:|||
Human   610 DE-ALPTEAQLLISSLLQTNPLVRLGA-GGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDT 672

  Fly  1136 SYFDTRMDRYNHDLGGEDTDDTDDTPV-FGSFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPP 1199
            ||||||.|||:|....::.|.|::.|| ...|:|.:|::.|.:.|
Human   673 SYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSS-------------------- 717

  Fly  1200 LSSLPSRAQETPAATVGATSTGALPKLKSGMGSGSGSGSGSG----------SGSASHDGVVNKF 1254
            :..|.....:||.|..|  |:...|..|......:|...|.|          .||
Human   718 MEQLSQHEPKTPVAAAG--SSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGS---------- 770

  Fly  1255 LNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQQPNPGATQRMQ---- 1315
               |::::.          |..:|.:|           :.|        ..|..||.:|..
Human   771 ---PEIKRF----------SASEASFL-----------EGE--------ASPPLGARRRFSALLE 803

  Fly  1316 -QRHSMPPNTTTIISTPATPPPTQTQATM--AATPPTATVGSFSRSTPESSQTDSDDFSPQINRK 1377
             .|.|.|............|.|:...|..  |..|...|.|..:.|..:|..||         |.
Human   804 PSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKEETQGEGTSSAGDSEATD---------RP 859

  Fly  1378 RKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQPKSMDGSTSGSSVKHHRSR 1442
            |.|    |:.|.     ..:..::|..:|.::.|.|      .:||..|.|     .:|:...||
Human   860 RPG----DLCPP-----SKDGDASGPRATNDLVLRR------ARHQQMSGD-----VAVEKRPSR 904

  Fly  1443 S---IVKSASALGLSLMTSLDNSQLAAQLCGIQSPGGGGNGSSTASSRDTSPCRELSPLVTNLKP 1504
            :   ::|||||..||:|....:...::.|....||   .:.||..||||:||.|:.||.|:.|:.
Human   905 TGGKVIKSASATALSVMIPAVDPHGSSPLASPMSP---RSLSSNPSSRDSSPSRDYSPAVSGLRS 966

  Fly  1505 PIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGL 1569
            ||.|:|..:.:|||:..||||.||||.|::||:|..|:||.||.||||...|||||||||.|.|:
Human   967 PITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPVHGM 1031

  Fly  1570 FHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKRE-HDKKRKT 1633
            .|.:|::|:|..|..|.:..||.|:|||:.|..:|...::|:|:    |.|:.:.:| .:.|:::
Human  1032 VHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMAR----RNKRPSAKEGQESKKRS 1092

  Fly  1634 SLFRRI--------SSKRANAEMQQYSAGTSSPTTPS----ARNLSPLDSSYHSSCCQSAANSSS 1686
            ||||:|        :|:..::..:..|:..|.|.:|:    ||  || ..||.|:...:...:||
Human  1093 SLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPAR--SP-THSYRSTPDSAYLGASS 1154

  Fly  1687 QSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSV 1751
            ||:||:||:||:| .||.|:|
Human  1155 QSSSPASSTPNSP-ASSASHH-------------------------------------------- 1174

  Fly  1752 GNVPVSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKS 1816
                           .||||||||..|||                          ......|.||
Human  1175 ---------------IRPSTLHGLSPKLH--------------------------RQYRSARCKS 1198

  Fly  1817 VGHIPLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSY------SPGSTLPTLQTA 1875
            .|:|||||||.||       |||::..|   ||.||..|:|:||||:      ||....|
Human  1199 AGNIPLSPLAHTP-------SPTQASPP---PLPGHTVGSSHTTQSFPAKLHSSPPVVRP----- 1248

  Fly  1876 VNANTKKAGFARTKSAE-PSSPLLRRALSPDRL------HPRSAETKISPLCCSPPIKQPTHQRV 1933
                       |.|||| |.||||:|..|.::|      ..:.|..|.|.....|..::..|..:
Human  1249 -----------RPKSAEPPRSPLLKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGEL 1302

  Fly  1934 VTTTWRSTPGGSASGAGGAVLGAPSVQPLQLVPAASEESQRQTAMATV---VSTTAAGTDPSATA 1995
            ...:...:.|.:....|   ||||                ||.|:..:   .|..:.|.||
Human  1303 ALHSLAESDGETPPVEG---LGAP----------------RQVAVRRLGRQESPLSLGADP---- 1344

  Fly  1996 VVTLANCEPLPRIAEEKDSP------------------------------TSTQDSS-----SVS 2025
            ::......| |..::||:||                              ..|:|.:     :|:
Human  1345 LLPEGASRP-PVSSKEKESPGGAEACTPPRATTPGGRTLERDVGCTRHQSVQTEDGTGGMARAVA 1408

  Fly  2026 EGFMPAIEEFAEGESSSS-----------------------------PTQTLEKPTKVKATEQPE 2061
            :..:..::|...|..|||                             .::.|::|..: |...||
Human  1409 KAALSPVQEHETGRRSSSGEAGTPLVPIVVEPARPGAKAVVPQPLGADSKGLQEPAPL-APSVPE 1472

  Fly  2062 MEPAGKSK---KVDQGKTTTPGTPKTKPHNSGCKTSMTTTKPASPSVTISTAPRK---DTSAVT- 2119
             .|.|:.:   :|.:.:||..| |::||     .:...:.:|.:||:    ||.|   .:||||
Human  1473 -APRGRERWVLEVVEERTTLSG-PRSKP-----ASPKLSPEPQTPSL----APAKCSAPSSAVTP 1526

  Fly  2120 -------GGGSSGSGGSAATSAAK 2136
                   |.|:....|..:...|:
Human  1527 VPPASLLGSGTKPQVGLTSRCPAE 1550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	160/365 (44%)
		STKc_MAST	834..1115	CDD:270760	208/280 (74%)
		S_TKc	835..1110	CDD:214567	206/274 (75%)
		PDZ_signaling	1506..1587	CDD:238492	44/80 (55%)
MAST1	NP_055790.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..80		19/59 (32%)
		DUF1908	61..337	CDD:286070	160/362 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..117		16/22 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..171		19/32 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..374		18/132 (14%)
		STKc_MAST	373..652	CDD:270760	208/280 (74%)
		S_TKc	374..647	CDD:214567	206/274 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..909		53/284 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	929..965		15/38 (39%)
		PDZ_signaling	968..1050	CDD:238492	44/81 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1184		46/185 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1200..1293		43/118 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1305..1570		55/282 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154017
Domainoid	1	1.000	441	1.000	Domainoid score	I548
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	982	1.000	Inparanoid score	I312
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm41421
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3124
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.880