Protein Alignment dop and kin-4

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: NP_001255551.1
• Gene: kin-4 / 178068
• WormBaseID: WBGene00002192
• Length: 1831
• Species: Caenorhabditis elegans
• Alignment Length: 2123
• Identity: 657/2123 - (30%)
• Similarity: 919/2123 - (43%)
• Gaps: 656/2123 - (30%)

  Fly     8 ASRPADGATGPVASSSSSTSS------NHSVSAVLGSKISTSTPQKNDEHQEQEFINQSVASEIE 66
            :|.|.|..|. .||:.|.|:|      :.|...:|....||.....:|        |::..:|..
 Worm   124 SSPPPDRRTS-FASTMSDTNSSITIPMSSSYQNLLSPMWSTMKYSSDD--------NETPPNEPS 179

  Fly    67 AMSISDSASAESSSGATATATATMSGSPVPKRHLSTANLSRIRPQSSYSARVLIFDDSDQE---- 127
            ......:.|..|||..........  |||..|.:.:     :.|..|.|.......:||.|
 Worm   180 PRRSKSALSNRSSSDCINVPPIVF--SPVLSRPIRS-----MSPTMSMSPTFRTHHNSDSESDTG 237

  Fly   128 AAAAAAALAAASSSCNSSVKSCSGLELLPTSPAKL------SIGNDSTNGSSMMRNL-------- 178
            |.||...|.|.:||.:..|...||..::|  |.:.      ..||||::.:|.:..|
 Worm   238 AQAAGVCLFACTSSASGLVWKGSGSLMIP--PRRSFHRPQGGGGNDSSDSNSNVERLLKRNRRRT 300

  Fly   179 ----------NLTKSSSGGLSGSSSSL--------HSRGYTALLRKISYQQHTNSLR-AVSGETS 224
                      ..|.:|:|..|.|.::|        ||....:.....|:...|:||. |....|:
 Worm   301 MAIHGVETEPGQTAASTGWTSASMTNLCRVRSSLGHSDPQLSSSSTNSFNTSTSSLHPATKSSTT 365

  Fly   225 NLLRMRHSSLGKS---APCLTGNYFRHELTAPLPVQPPGFGASPLGGHNISRSGSCAGIGLAKHH 286
            .|.....||..:|   .|.|      |..|:|:.:|.   ..||:.....|.|.|
 Worm   366 ALSSFSTSSANRSPANRPSL------HSSTSPVTLQR---CRSPMRVPQRSTSSS---------- 411

  Fly   287 HHHHLHGVVMRGSAGGGAGSGGGS-SSGVAHHRLSLVTNSAAVAAAGGSRTHSPYSASPVDSPRL 350
              |:.      |:||.|..|.|.| .||.       :|.|..       ||:|..:.|.:.:|
 Worm   412 --HNF------GAAGAGPSSSGSSVHSGT-------ITLSVC-------RTYSARNGSSLMAP-- 452

  Fly   351 NSPMPFAFAPIKRIASCRGVVADGRRWSVASLPS-SGYGT--TPGSSNLSSQCSSQEGLNQLAHN 412
                                |.|.||||:||||| |||||  |..:|.:|||.||.|.:.::
 Worm   453 --------------------VQDTRRWSLASLPSTSGYGTPGTGSNSGVSSQYSSSEQIGEM--- 494

  Fly   413 IPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNC 477
                                                :.|.:::
 Worm   495 ------------------------------------LDQTRIS---------------------- 501

  Fly   478 CAELSVTCGGQQAGGGAANGGSSANSSGS-----SAMQVGGRMSPYFRPRSRSLSSPSRSPIVDN 537
                          |......|..:|:.|     |..|...:.:...|||||||:||.:. :.:.
 Worm   502 --------------GPVRQNSSRFDSNDSYDDMASHQQAAAQNAFLNRPRSRSLTSPMKF-LNEY 551

  Fly   538 EIAVMN--TLYKERFPKATQQMEERLKLFINEN---------KSA-------------------- 571
            .|.::|  ::||||||:|..||||||..|:.||         :||
 Worm   552 NIEMVNRTSVYKERFPRAKLQMEERLNAFVAENGPLSGGISQQSARDDTDRVDDLSARQSGSSSG 616

  Fly   572 --------------------ACNSFRDSQPI-------VRFVHHQVLEMARDCLHKSEAKLITSQ 609
                                ...|:.|...:       .||:|||::|:|.|||.||:..|||..
 Worm   617 LKAKDSVEEAVMRSRRSTVLEAESYADRSLLRLIGDGATRFLHHQIVEIALDCLGKSKDDLITCS 681

  Fly   610 YFYELSENLERLLVETKEK-SPEAAAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEG 673
            ||.|:|:.||..|.|.:.| |||:...|:.::||||:|:||||||||||||||.|||.|||.|||
 Worm   682 YFCEMSQRLEETLNEAQMKTSPESLEYLSKLVKKLLMIVSRPARLLECLEFDPDEFYHLLEEAEG 746

  Fly   674 HAKAMPVIK----------ADIPQYIIHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPG 728
                  |::          .|:|||||.||||:|||:.:..:.
 Worm   747 ------VVREQLGSGTARVPDLPQYIIGKLGLDRDPLIDSTEH---------------------- 783

  Fly   729 GSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGG 793
                                     :||...|                           :....|
 Worm   784 -------------------------VDSSENT---------------------------HATTSG 796

  Fly   794 SSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTR 858
            ::||.|.||:.:....                   :|.|:|||.::|:|||||||||||:|:.||
 Worm   797 TTSAKGAGSAWQETNR-------------------APCEDDFDTIRLVSNGAYGAVYLVRHRETR 842

  Fly   859 QRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTL 923
            ||||:||:||..|:|||||:|||||||||:.||||||||.|.||||:::||::|||||||||..|
 Worm   843 QRFALKKMNKQTLMLRNQVDQVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGDCAAL 907

  Fly   924 LKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLA 988
            ||:.|.||.::.|.|.|||:||:||||||||||||||||||||||:||||||||||||:|||:..
 Worm   908 LKSAGTLPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRT 972

  Fly   989 TNLYEGYIDS--ETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGE 1051
            |.:.||| |:  ||:||.|||:.|||||||||||||:|||||||||::||||||||:|.||||||
 Worm   973 TLVAEGY-DAVVETQQFQDKQLCGTPEYIAPEVILRRGYGKPVDWWALGIILYEFLVGIVPFFGE 1036

  Fly  1052 TTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWN 1116
            |.|.||:..:::|:|:|: ||..:..||.|:..:||::||.:||||.:||.::..||:|:.:|:.
 Worm  1037 TPEALFSKVISEDVEYPE-EDEALPPEAADLCRRLLEKNPAERLGTLNGAAQLMAHEFFILLDFT 1100

  Fly  1117 SLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHD---LGGEDT--DDTDDTPVFGSFNSYTPQYR-- 1174
            |||||||||||||.:::||||||||.|||||:   .|.|:.  .....:.:|.||::.:|::.
 Worm  1101 SLLRQKAEFVPQLDNEEDTSYFDTRTDRYNHEAESCGEEEIVGSSAASSMMFHSFSTASPRHSIV 1165

  Fly  1175 ---KQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGATSTGALPKLKSGMGSGSGS 1236
               ..|..   |...|:...||........|:.||.:..|..:.   |||..|
 Worm  1166 SIDPAHLP---HLLSTANAAAKEIERSHSVSMSSRPETRPERSY---STGQAP------------ 1212

  Fly  1237 GSGSGSGSASHDGVVNKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKH 1301
                                                         |||.   .:|:|
 Worm  1213 ---------------------------------------------PELF---KVGDD-------- 1221

  Fly  1302 YLQQPNPGATQRMQQRHSMPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRSTPESSQTD 1366
                 |......:::|.|...:..:..|:..|     ...|..||..::|..|...|:....|..
 Worm  1222 -----NTSTAVNLRRRFSAQRHNVSTTSSSGT-----GSGTCFATAASSTDSSIDASSLPLFQPP 1276

  Fly  1367 SDDFSPQINRKRKGVC---ARDILPRFSISIEDET-ISAGSSSTENMNLPREQSPLALQHQPKSM 1427
            |          |..:.   :|..||:||||.|.|. :|......::::..|..:.::
 Worm  1277 S----------RSSIAERGSRSPLPKFSISCEGEAGVSRSGDDHDDLDDSRNSTIVS-------- 1323

  Fly  1428 DGSTSGS--SVKHHRSRSIVKSASALGLSLMTSLDNSQL------AAQLCGIQSPG--------- 1475
            ..|:.|:  :|:..|..|....||.|.| ::.|:.:||.      |.:.|.:..|.
 Worm  1324 TASSGGADETVRFRRQSSGRTPASQLQL-VIPSISSSQSSQSAEPARETCYVMYPSGPSTSVGSQ 1387

  Fly  1476 ---GGGNGSSTASSRDTS-----PCRELSPLV----------TNLKPPIIIRRGPRGFGFTVHTI 1522
               ||.:.||.:||.|..     |.....||.          |.....|.||:||.|||||:.::
 Worm  1388 LSPGGASVSSASSSNDVGSPHPLPLHHEHPLTSHDSSAASSSTAPSKTITIRKGPFGFGFTLKSV 1452

  Fly  1523 RVYYGD-TDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLFHTQVLQLLLSGGEHVT 1586
            |||.|: :::||:.|:|.||.||||||.|.|:..|:||||||..|..|.|.|::..||:.|..:.
 Worm  1453 RVYLGEHSEYYTIEHIVTAVVEGSPAFHANLQAEDMITHVNGHPVHNLTHPQLMHRLLANGNELI 1517

  Fly  1587 LRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTS-LFRRISSKRANAEMQQ 1650
            ||..||.:|||:.|..:|.:  .|:|:|...|.:::......|.||.| |.||:|.|||..::
 Worm  1518 LRLVPLANTSIREGAARRTV--GKMARKKPKRPQRRVVPLEKKTRKPSALLRRLSGKRATNDI-- 1578

  Fly  1651 YSAGTSSPTTPSARNLSPLDSSYHSSCC------QSAANSSSQSTSPSSSS-------------- 1695
             ..|:||    ..:...|..:|....|.      .|..:....|..||:||
 Worm  1579 -VPGSSS----QKQAFMPRSASSQDGCILTHLPGTSKISQQEASQEPSTSSQGMVRRSVNEIETN 1638

  Fly  1696 -PNTPTGSSGS----NHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVP 1755
             |::...:|.|    :|..:..|||.||:.    |||..|       .::..:..|:|:|
 Worm  1639 RPSSLRSTSNSHHHHHHPASTSSVASAPAT----LPSTTP-------SNLSRMASSSPSS----- 1687

  Fly  1756 VSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHI 1820
                                          .|.....::||.      |::..|:..::..  .|
 Worm  1688 ------------------------------SASNSGTSSPAA------TSSGISIVKQKSQ--SI 1714

  Fly  1821 PLSPLA-----RTPSPS-----PLPSSPTRSPSPLAFPLVGHQPGASNTTQ-------------- 1861
            .:||||     |:||||     |..||.|..|..:..|.....|..|...|
 Worm  1715 AVSPLARDTRMRSPSPSHLHHRPASSSYTTRPDGVVTPATSSSPNNSGFVQDLISSRQSPNLSAR 1779

  Fly  1862 --SYSPGSTLPTLQTAVNANTKKAGFARTKSAEPSSPLLRRAL 1902
              ||.|.:|...:......:.:  ||  :.:|:.:..||.|.|
 Worm  1780 RRSYQPTTTTSMIVPPTTHHLR--GF--SAAAQSAQDLLNRLL 1818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	133/434 (31%)
		STKc_MAST	834..1115	CDD:270760	189/282 (67%)
		PDZ_MAST	1502..1594	CDD:467189	46/92 (50%)
kin-4	NP_001255551.1	DUF1908	455..779	CDD:462637	131/405 (32%)
		STKc_MAST	818..1099	CDD:270760	189/282 (67%)
		PDZ_MAST	1434..1525	CDD:467189	46/90 (51%)