Protein Alignment dop and Mast2

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: NP_001355990.1
• Gene: Mast2 / 17776
• MGIID: 894676
• Length: 1801
• Species: Mus musculus
• Alignment Length: 2027
• Identity: 734/2027 - (36%)
• Similarity: 959/2027 - (47%)
• Gaps: 590/2027 - (29%)

  Fly   156 PTSPAKLSIGNDSTNGSSMMRNLNLTKSSSG-GLSGSSSSLHSRGYTALLRKISYQQHTNSLRAV 219
            ||...||.  ...:.....:|..:|..|.|| .|...|||:||.     :.::::|.
Mouse    82 PTGKVKLQ--RQLSQDDCKLRRGSLASSLSGKQLLPLSSSVHSS-----VGQVTWQS-------- 131

  Fly   220 SGETSNLLRMRHSSLGKSAPCLTGNYFRHELTAPLPVQPPGFGASPLGGHNISRSGS-CAGIGLA 283
            :||.|||:|||:.|||:|||.||...  .||:.|                   |.|| |.
Mouse   132 TGEASNLVRMRNQSLGQSAPSLTAGL--KELSLP-------------------RRGSFCR----- 170

  Fly   284 KHHHHHHLHGVVMRGSAGGGAGSGGGSSSGVAHHRLSLVTNSAAVAAAGGSRTHSPYSA----SP 344
                                           ..:|.||:..|:.....  .|.|||...    ||
Mouse   171 -------------------------------TSNRKSLIVTSSTSPTL--PRPHSPLHGHTGNSP 202

  Fly   345 VDSPR---LNSPMPFAFAPIKRIASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGL 406
            :||||   .|:|..|:|.| .|....|....||||||:||||||||||...||.:||.|||||.|
Mouse   203 LDSPRNFSPNAPAHFSFVP-ARSHGHRTDRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKL 266

  Fly   407 NQLAHNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMT 471
            :||     |....||..             ....||.:                 |:..|.:.
Mouse   267 HQL-----PFQPTADEL-------------HFLTKHFS-----------------TENVPDEE-- 294

  Fly   472 AACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSPI-V 535
                                                     ||.||..||||||| ||.|||: .
Mouse   295 -----------------------------------------GRRSPAMRPRSRSL-SPGRSPVSF 317

  Fly   536 DNEIAVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHK 600
            |:||.:||.:|||||||||.||||||..||:.|...:.....|.  .:.|:||||:|||||||.|
Mouse   318 DSEIIMMNHVYKERFPKATAQMEERLADFISSNTPDSVLPLADG--ALSFIHHQVIEMARDCLDK 380

  Fly   601 SEAKLITSQYFYELSENLERLLVETKEKSPEA-AAELNGVIKKLLLIISRPARLLECLEFDPQEF 664
            |.:.||||.|||||.||||:||.:..|:|..: .|.:..::|||::||:|||||||||||||:||
Mouse   381 SRSGLITSHYFYELQENLEKLLQDAHERSESSDVAFVIQLVKKLMIIIARPARLLECLEFDPEEF 445

  Fly   665 YELLEAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGG 729
            |.||||||||||....||.|||:||:.:|||.|||:.|:
Mouse   446 YHLLEAAEGHAKEGHGIKCDIPRYIVSQLGLTRDPLEEM-------------------------- 484

  Fly   730 SLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGS 794
                        .||||       .||          |.|| .|.|
Mouse   485 ------------AQLSS-------YDS----------PDTP-ETDD------------------- 500

  Fly   795 SSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPS---PQENDFDIVKLISNGAYGAVYLVKHKT 856
                                    :..|.|..|||   |.|.||:.:|||||||||||:||:||:
Mouse   501 ------------------------SVEGRGVSQPSQKTPSEEDFETIKLISNGAYGAVFLVRHKS 541

  Fly   857 TRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCG 921
            ||||||||||||.|||||||::|.|.|||||:||:|||||||:||||||:|||:||||||||||.
Mouse   542 TRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCA 606

  Fly   922 TLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMS 986
            |||||||.||.||.|.||||||||:||||:||||||||||||||||::||||||||||||:||||
Mouse   607 TLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMS 671

  Fly   987 LATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGE 1051
            |.||||||:|:.:.|:|.||||.|||||||||||||||||||||||:|||||||||:|||||||:
Mouse   672 LTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGD 736

  Fly  1052 TTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWN 1116
            |.||||...::|:|.||:.:| .:..:|:|:.|:||.|||.:|||| |.|.|:|:|.:|:|:||.
Mouse   737 TPEELFGQVISDEIVWPEGDD-ALPPDAQDLTSKLLHQNPLERLGT-SSAYEVKQHPFFMGLDWT 799

  Fly  1117 SLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDTDDTPVFG-----SFNSYTPQYRKQ 1176
            .||||||||:|||..:|||||||||.:||:|    .|::|.::....|     .|:|.:|::.|.
Mouse   800 GLLRQKAEFIPQLESEDDTSYFDTRSERYHH----VDSEDEEEVSEDGCLEIRQFSSCSPRFSKV 860

  Fly  1177 HYSWSRHATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGATSTGALPKLKSGMGSGSGSGSGSG 1241
            :.|..|    .|....:.|.||...||....::.                ..|:....|......
Mouse   861 YSSMER----LSLLEERRTPPPTKRSLSEEKEDH----------------SDGLAGLKGRDRSWV 905

  Fly  1242 SGSASHDGVVNKFLNTPQLRKLDLSSSCLKVPST--------PDADYLPELLHNVTIGNDAELRM 1298
            .||..   ::.|.|:..:....:..||   .|.|        ||..:.||
Mouse   906 IGSPE---ILRKRLSVSESSHTESDSS---PPMTVRHRCSGLPDGPHCPE--------------- 949

  Fly  1299 LKHYLQQPNPGATQRMQQRHS----MPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRST 1359
                    ...:|.|.||:..    :||:... .|.|....|.:.|..:...||    |..||.
Mouse   950 --------ETSSTPRKQQQEGIWVLIPPSGEG-SSRPVPERPLERQLKLDEEPP----GQSSRC- 1000

  Fly  1360 PESSQTDSDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQP 1424
                       .|.:..:.:|.      |:.:   |:.|..|             .|.||::
Mouse  1001 -----------CPALETRGRGT------PQLA---EEATAKA-------------ISDLAVR--- 1029

  Fly  1425 KSMDGSTSGSSVKHHRSR---SIVKSASALGLSLMTSLDNSQLAAQLCG-IQSPGGGGNGSSTAS 1485
            ::.....||.|::...:|   .::|||||..|||:...::     ..|. :.||....:.||..|
Mouse  1030 RARHRLLSGDSIEKRTTRPVNKVIKSASATALSLLIPSEH-----HACSPLASPMSPHSQSSNPS 1089

  Fly  1486 SRDTSPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEA 1550
            |||:||.|:..|.:.:|:|||||.|..:.:|||:..||||.||||.||:||:|..|::|.||.||
Mouse  1090 SRDSSPSRDFLPALGSLRPPIIIHRAGKKYGFTLRAIRVYMGDTDVYTVHHMVWHVEDGGPASEA 1154

  Fly  1551 GLRPADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKG 1615
            |||..|||||||||.|.||.||:|::|:|..|..|::..||||:|||:.|..::...::|:|::.
Mouse  1155 GLRQGDLITHVNGEPVHGLVHTEVVELVLKSGNKVSISTTPLENTSIKVGPARKGSYKAKMARRS 1219

  Fly  1616 VNRQKKQTKREHDKKRKTSLFRRI--------SSKRANAEMQQYSAGTSSPTTPS-ARNLSPLD- 1670
               ::.:.|...:.::::||||:|        :|:..::..:..|:|.|.|.:|: :.:|||..
Mouse  1220 ---KRSKGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSP 1281

  Fly  1671 -SSYH--SSCCQSAANSSSQSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPT 1732
             ..|.  .....|...:||||:|||||.|::|.||.
Mouse  1282 PQGYRVAPDAVHSVGGNSSQSSSPSSSVPSSPAGSG----------------------------- 1317

  Fly  1733 QLVLLPHVGAVVGSNPTSVGNVPVSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAG 1797
                                             :.|||:||||..||..         ...:|
Mouse  1318 ---------------------------------HTRPSSLHGLAPKLQR---------QYRSP-- 1338

  Fly  1798 GLKTLHTTNNNSLPNRRKSVGHIPLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQS 1862
                           ||||.|.|||||||.||||....:||.||||||:    ||...:..|...
Mouse  1339 ---------------RRKSAGSIPLSPLAHTPSPPATAASPQRSPSPLS----GHGSQSFPTKLH 1384

  Fly  1863 YSP--GSTLPTLQTAVNANTKKAGFARTKSAE-PSSPLLRRALSPDRLHP--RSAETKISPLCCS 1922
            .||  |..|                :|.|||| |.||||:|..|.::|..  .:||.|::|
Mouse  1385 LSPPLGRQL----------------SRPKSAEPPRSPLLKRVQSAEKLAAALAAAEKKLAP---- 1429

  Fly  1923 PPIKQPTHQRVVTTTWRSTPGGSASGAGGAVLGAPSVQPLQLVPAASEESQRQTAMATVVSTTAA 1987
                ...|.       ...|.|...                     .|.:.|:.:...||.|.:
Mouse  1430 ----SRKHS-------LDLPHGELK---------------------KELTPREASPLEVVGTRS- 1461

  Fly  1988 GTDPSATAVVTLANCEPLPRIAEEKDSP-----TSTQDSSSVSEGFMPAIEEFAEGESSSSPTQT 2047
                      .|:...|||.....:.:|     |..||.:...|...   ::.|..|..||...|
Mouse  1462 ----------VLSGKGPLPGKGVLQPAPSRALGTLRQDRAERRESLQ---KQEAIREVDSSEDDT 1513

  Fly  2048 LEKPTKVKATEQPEMEPAGKSKKVDQGKTTTPGT----------PKTKPHNSGCKTSMTTTKPAS 2102
            .|:|...:||::|.:.|..::......|.:..||          .|..|..||..|..|.   .|
Mouse  1514 DEEPENSQATQEPRLSPHPEASHNLLPKGSGEGTEEDTFLHRDLKKQGPVLSGLVTGATL---GS 1575

  Fly  2103 PSVTI-STAPRK 2113
            |.|.: ..:|||
Mouse  1576 PRVDVPGLSPRK 1587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	163/362 (45%)
		STKc_MAST	834..1115	CDD:270760	209/280 (75%)
		PDZ_MAST	1502..1594	CDD:467189	54/91 (59%)
Mast2	NP_001355990.1	DUF1908	202..483	CDD:462637	163/362 (45%)
		STKc_MAST	519..798	CDD:270760	209/280 (75%)
		PDZ_MAST2	1106..1198	CDD:467287	54/91 (59%)