Protein Alignment dop and DMPK

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: NP_001411092.1
• Gene: DMPK / 1760
• HGNCID: 2933
• Length: 656
• Species: Homo sapiens
• Alignment Length: 796
• Identity: 199/796 - (25%)
• Similarity: 301/796 - (37%)
• Gaps: 242/796 - (30%)

  Fly   782 LAISQMNEEKGGSSSAVGGGSSSKVAGA-----EGITGGSAATATGSG----------------- 824
            |.:..::.....::.|.|.|.....|||     .|...|:....||.|
Human     3 LPVQHVSRGAAEAAPAAGVGPGLPGAGAPARPSPGRPPGAGRLRTGPGQVRGRLLAVGPKSRVFQ 67

  Fly   825 --AQQPSP-----------------QENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNN 870
              .|:|..                 |.:||:|:|:|..||:..|.:||.|.|.|.:|||.:||.:
Human    68 SVVQEPPASESRAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWD 132

  Fly   871 LILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGP-LPADM 934
            ::.|.:|.....|||:|...|..::..::.:|:.:.:|.|||||..|||..|||...|. :||:|
Human   133 MLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEM 197

  Fly   935 ARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSE 999
            ||||.||.|:|::.:|..|.||||:||||:|:...|||:|.||| |.:.|.:          |..
Human   198 ARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFG-SCLKLRA----------DGT 251

  Fly  1000 TRQFSDKQVYGTPEYIAPEVILRQG-------YGKPVDWWSMGIILYEFLIGCVPFFGETTEELF 1057
            .|..   ...|||:|::||::...|       ||...|||::|:..||...|..||:.::|.|.:
Human   252 VRSL---VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETY 313

  Fly  1058 AHTVN--DDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLR 1120
            ...|:  :.:..| ..|..|..||:|.|.:||.. |..||| :.||.:.:.|.:|.|:||:.|..
Human   314 GKIVHYKEHLSLP-LVDEGVPEEARDFIQRLLCP-PETRLG-RGGAGDFRTHPFFFGLDWDGLRD 375

  Fly  1121 QKAEFVPQLSHDDDTSYFDTRMDRYNHDL--GGEDTDDTDDTPVFGSFNSYTPQYRKQHYSWSRH 1183
            ....|.|......||..||...|.....:  |||...|..:....|....:.      .||:|..
Human   376 SVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFV------GYSYSCM 434

  Fly  1184 ATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGATSTGALPKLKSGMGSGSGSGSGSGSGSASHD 1248
            |.   .|...| ||.|:
Human   435 AL---RDSEVP-GPTPM------------------------------------------------ 447

  Fly  1249 GVVNKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQQPN--PGAT 1311
                                              ||        :|| ::|:.::|.|:  |..:
Human   448 ----------------------------------EL--------EAE-QLLEPHVQAPSLEPSVS 469

  Fly  1312 QRMQQRHSMPPNTTTIISTPATPPPTQTQATM-------AATPPTATVGSFSRSTPESSQTDSDD 1369
                     |.:.|..::.||..|..:.:|.:       |......|..|.||.. |:.:||:.:
Human   470 ---------PQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREM-EAIRTDNQN 524

  Fly  1370 FSPQINRKRKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQPKSMDGSTSGS 1434
            |:.|:.                           .:...|.:|......|..:.:....:|:|:.:
Human   525 FASQLR---------------------------EAEARNRDLEAHVRQLQERMELLQAEGATAVT 562

  Fly  1435 SVKHHRSRS----------IVKSASALGLSLMTSLDNSQLAAQLCGIQSPGGGGNGSSTASSRDT 1489
            .|...|:..          :..||...|.:..|       ||..|.:  ||..|     .:.|..
Human   563 GVPSPRATDPPSHMAPRPWLWASARWWGQAPCT-------AATCCSL--PGSLG-----LAYRRR 613

  Fly  1490 SPCRELSPLVTNLKPP 1505
            .|| ..|||...:.||
Human   614 FPC-SCSPLFCLVPPP 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637
		STKc_MAST	834..1115	CDD:270760	111/290 (38%)
		PDZ_MAST	1502..1594	CDD:467189	2/4 (50%)
DMPK	NP_001411092.1	STKc_DMPK_like	95..432	CDD:270748	128/359 (36%)
		DMPK_coil	496..556	CDD:117396	13/87 (15%)