DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and Dmpk

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	XP_006539579.1	Gene:	Dmpk / 13400	MGIID:	94906	Length:	653	Species:	Mus musculus

Alignment Length:	575	Identity:	176/575 - (30%)
Similarity:	265/575 - (46%)	Gaps:	105/575 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   831 QENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFV 895
            |.:||:|:|:|..||:..|.:||.|.|.|.:|||.:||.:::.|.:|.....|||:|...|..::
Mouse    67 QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVKGDRRWI 131

  Fly   896 VSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGP-LPADMARFYFAETVLAVEYLHSYGIVHRDL 959
            ..::.:|:.:.:|.|||||..|||..|||...|. :||:|||||.||.|:|::.:|..|.||||:
Mouse   132 TQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDI 196

  Fly   960 KPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQG 1024
            ||||:|:...|||:|.||| |.:.|..      :|.:.|..       ..|||:|::||::...|
Mouse   197 KPDNILLDRCGHIRLADFG-SCLKLQP------DGMVRSLV-------AVGTPDYLSPEILQAVG 247

  Fly  1025 -------YGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVN--DDIEWPDSEDWPVQAEAK 1080
                   ||...|||::|:..||...|..||:.::|.|.:|..|:  :.:..| ..|..|..||:
Mouse   248 GGPGAGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYAKIVHYREHLSLP-LADTVVPEEAQ 311

  Fly  1081 DIISQLLQQNPRD-RLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDR 1144
            |:|..||  .|.: ||| :.||.:.::|.:|.|:||..|......|.|......||..||...||
Mouse   312 DLIRGLL--CPAEIRLG-RGGAGDFQKHPFFFGLDWEGLRDSVPPFTPDFEGATDTCNFDVVEDR 373

  Fly  1145 YNHDL--GGEDTDD-TDDTPV-----FGSFNSYTPQYRKQHYSWSRHATPTSTDGAK-PTG---- 1196
            ....:  |||...| .:|.|:     |..::.....:|.....   ..||...:..: |..
Mouse   374 LTAMVSGGGETLSDMQEDMPLGVRLPFVGYSYCCMAFRDNQVP---DPTPMELEALQLPVSDLQG 435

  Fly  1197 ---PPPLSSLPSRAQE-----TPAATVGATSTGALPKLKSGMGSGSGSGSGSGSGSASHDGVVNK 1253
               .||:|.....|:|     .||....|.:|..|.:|:..
Mouse   436 LDLQPPVSPPDQVAEEADLVAVPAPVAEAETTVTLQQLQEA------------------------ 476

  Fly  1254 FLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRM--LKHYLQQPNPGATQRMQQ 1316
             |....|.:..||.. |:...|.:.::..:|       .:||:|.  |:.:::|        :|:
Mouse   477 -LEEEVLTRQSLSRE-LEAIRTANQNFSSQL-------QEAEVRNRDLEAHVRQ--------LQE 524

  Fly  1317 RHSM--PPNTTTIISTP---ATPPPTQTQATMAATPPTATVGSFSRSTPESSQTD 1366
            |..|  .|....|...|   ||.||:.    :.|.|....:||...:.|.|.|.|
Mouse   525 RMEMLQAPGAAAITGVPSPRATDPPSH----IPALPLALLLGSDRVTCPFSLQLD 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070
		STKc_MAST	834..1115	CDD:270760	112/291 (38%)
		S_TKc	835..1110	CDD:214567	109/285 (38%)
		PDZ_signaling	1506..1587	CDD:238492
Dmpk	XP_006539579.1	PKc_like	69..405	CDD:389743	130/353 (37%)
Dmpk	XP_006539579.1	DMPK_coil	472..532	CDD:117396	16/100 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844255
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930