Protein Alignment dop and mast3a

DIOPT Version :10

• Sequence 1: NP_648778.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Sequence 2: XP_021326924.2
• Gene: mast3a / 100534685
• ZFINID: ZDB-GENE-040914-35
• Length: 1355
• Species: Danio rerio
• Alignment Length: 1802
• Identity: 635/1802 - (35%)
• Similarity: 840/1802 - (46%)
• Gaps: 537/1802 - (29%)

  Fly   334 SRTHSPYSASPVDSPRLNSPMPFAFAP-IKRIASCRGVVADGRRWSVASLPSSGYGTTPGSSNLS 397
            |..|.|..:||:||||..|..|....| |:|        .|.|||||||: ||||||.|.||.:|
Zfish    47 SPLHLPTGSSPLDSPRNVSGSPSVNFPFIRR--------PDTRRWSVASV-SSGYGTNPPSSAVS 102

  Fly   398 SQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPT 462
            |..||||.|:||                                              |..|.|.
Zfish   103 SSSSSQELLHQL----------------------------------------------PSQPTPD 121

  Fly   463 QLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLS 527
            .|                               |.......|..|.....|:.| .|.|||||||
Zfish   122 DL-------------------------------NRLFKHFRSTESVADEDGQPS-RFHPRSRSLS 154

  Fly   528 SPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFRDSQP-----IVRFVH 587
            ........||||.:||.:|||||||||.|||.||...|.:...       ||.|     ::.|:.
Zfish   155 PGRTCGSFDNEIVMMNHVYKERFPKATAQMEGRLLAVIADYSP-------DSAPPLADGVLGFIQ 212

  Fly   588 HQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKS-PEAAAELNGVIKKLLLIISRPA 651
            ||::|:.||||.||...||||.||.||.|.||..|.|..|:| .|....:..::||:|:||||||
Zfish   213 HQLVELVRDCLEKSRKGLITSSYFMELQEKLENFLHEAYERSESEEVTVIAKLVKKILIIISRPA 277

  Fly   652 RLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAELQQELRETQQMCSE 716
            ||||||||||:|||:.||.|||.||....||.|||:|||.:|||.|||:.::.|
Zfish   278 RLLECLEFDPEEFYQRLEVAEGQAKVGQGIKTDIPRYIISQLGLTRDPLEDMVQ----------- 331

  Fly   717 QVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATCDTAPSFA 781
                           |.::...|::::|...|      ::..|..||::
Zfish   332 ---------------LEHNSSGSSSRELDDSA------ENRPGIMTPRR---------------- 359

  Fly   782 LAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPSPQENDFDIVKLISNGAY 846
                                                           .|.|.||:.:||||||||
Zfish   360 -----------------------------------------------KPLERDFETIKLISNGAY 377

  Fly   847 GAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLV 911
            ||||||:|:.|||||||||||:.|||||||::|||.|||||:||:|||||||||||||::|||:|
Zfish   378 GAVYLVRHRETRQRFAMKKINRQNLILRNQIQQVFVERDILTFAENPFVVSMYCSFETRRHLCMV 442

  Fly   912 MEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTD 976
            |||||||||..||||:||||.||||.||||||||:||||:||||||||||||||||::|||||||
Zfish   443 MEYVEGGDCANLLKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTD 507

  Fly   977 FGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEF 1041
            |||||:|||::.|||||.:::.:||:|.|||:.|||||||||||||||||||||||:||||||||
Zfish   508 FGLSKIGLMNMTTNLYEEHMEKDTREFIDKQLCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEF 572

  Fly  1042 LIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKE 1106
            |:|||||||:|.||||...|:|:||||..:| .:.||::|:|::||:|:|.:|||| .||.|:|.
Zfish   573 LVGCVPFFGDTPEELFGQVVSDEIEWPVGDD-ALPAESQDLITKLLRQSPLERLGT-GGAAEVKH 635

  Fly  1107 HEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDTDDTPVFG--SFNSY 1169
            |.:|.|:||:.||||||||:|||..:|||||||||.|||:|   .::.|:|:|...:.  .|:|.
Zfish   636 HIFFHGLDWSGLLRQKAEFIPQLETEDDTSYFDTRSDRYHH---SDEDDETNDDESYQDIKFSSC 697

  Fly  1170 TPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGATSTGALPKLKSGMGSGS 1234
            :.::.|.:.|..:.|:|::
Zfish   698 SHRFSKVYSSSEQLASPSN---------------------------------------------- 716

  Fly  1235 GSGSGSGSGSASHDGVVNKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRML 1299
                                        |.||||                  ..:...:.|.|..
Zfish   717 ----------------------------LSLSSS------------------ERSCSEEKEDRWD 735

  Fly  1300 KHYLQQPNPGATQRMQQRHSMPPNTTTIISTP-ATPPPTQTQATMAATPPTATVGSFSRSTPESS 1363
            .|....|                     :.|| ...|..:.|.|...:|......|.|.|.||..
Zfish   736 THSALSP---------------------VETPRQIQPADRKQDTSRGSPSLRPRASSSSSQPERG 779

  Fly  1364 QTDSDDFSPQINRKRKGVCARDILPRFSISIEDE---------TISAGSSSTENMNLPREQSPLA 1419
            .      ||.|....:.:   :.:|.|:...::|         .:.:.|:.|...|....:.|..
Zfish   780 T------SPLILNSTQSL---EAMPHFAFPEDEEGLVSNLRRIRLRSNSTGTRPTNRRDHKGPRR 835

  Fly  1420 LQHQPKSMDGSTSGSSVKHHRSRSIVKSASALGLSLMTSLDNSQLAAQLCGIQ-SPGGGGNGSST 1483
            |..|.::.:...|..:.|      :.||||..||||:.:.|:..     .|:| ||....:.||.
Zfish   836 LGLQQETPEKPRSPFTCK------VPKSASVSGLSLIVTADDIP-----SGLQTSPMSSHSLSSN 889

  Fly  1484 ASSRDTSPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAF 1548
            .||||:||.|::|...::|:||::|....|.:||.:..||||.||:|.||:||:|.:|::.|||.
Zfish   890 PSSRDSSPNRDISLSTSSLRPPVVIHSSGRKYGFALRAIRVYMGDSDVYTVHHMVWSVEDCSPAH 954

  Fly  1549 EAGLRPADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAK 1613
            |||||..|||||||||.:|||.||.|::|||..|..|||:.||||:|||:.|..::...:.|:|:
Zfish   955 EAGLRAGDLITHVNGECIQGLVHTDVVELLLKSGSKVTLQTTPLENTSIKIGPARKTSSKGKMAR 1019

  Fly  1614 KGVNRQKKQTKREHDKKRKTSLFRRISSKRANAE-MQQYSAG-TSSPTTPSARNLSPLDSSYHSS 1676
                |.||..::|....::.:|.:::.......: .:.:||| ..||....:.:.:|..|...::
Zfish  1020 ----RSKKSKRKEGQDSKRRNLLKKLPKHSPGIQNSRSFSAGFQHSPNDSLSDSPTPSLSPGPNT 1080

  Fly  1677 CCQSAA------NSSSQSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLV 1735
            .|:|.|      ::|.||:||.|||||:|
Zfish  1081 PCRSPAPDLSCDSNSPQSSSPCSSSPNSP------------------------------------ 1109

  Fly  1736 LLPHVGAVVGSNPTSVGNVPVSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLK 1800
                                      :||  .|||:||.|..|:                  ||:
Zfish  1110 --------------------------IPQ--SRPSSLHVLGSKI------------------GLR 1128

  Fly  1801 TLHTTNNNSLPNRRKSVGHIPLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSYSP 1865
                   .|...|.||...||.||||..||..||  ||..|||.|..|..||.   |...:..||
Zfish  1129 -------YSKAGRCKSSNSIPPSPLACNPSSQPL--SPQCSPSSLTGPPKGHH---SFHNKMMSP 1181

  Fly  1866 GSTLPTL--QTAVNANTKKAGFARTKSAE-PSSPLLRRALSPDRLHPRSAETKISPLCCSPPIKQ 1927
                ||:  ||..           .:||| |.||||.|..|.:||.......|.|       ...
Zfish  1182 ----PTIVRQTVC-----------PRSAESPRSPLLNRVQSSERLSSAQYGDKRS-------FSS 1224

  Fly  1928 PTH----QRVVTTTWRSTPGGSASGAGGAVLGAPSVQPLQLVPAASEESQRQTAMATVVSTTAAG 1988
            |.|    .:.....:.|.....|||.  ..:|..:.|.|.:......||
Zfish  1225 PRHTVEFPQSEADEFESQSPDIASGF--VCVGDHARQGLYMSGQRVRES---------------- 1271

  Fly  1989 TDPSATAVVTLANCEPLPRIAEEKDSPTSTQDSSSVSEGFMPAIEEFAEGES------SSSPTQT 2047
               |...:..|..||              .:||....|    |::|.:..:|      :|:||.:
Zfish  1272 ---SGLVMRKLNLCE--------------RRDSFKKQE----AVQEVSFDDSDDKELTTSTPTHS 1315

  Fly  2048 LEKPTKVKAT-EQPEMEPAGKSKKVDQGKTTTPGTPK--TKPHNSGC 2091
            ..|.:.|..| ::.:.|.:|:       ||...|:.:  .|.|...|
Zfish  1316 RFKVSWVSETQDEGDSETSGR-------KTDEVGSKRQEQKKHKDEC 1355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_648778.1	DUF1908	344..702	CDD:462637	146/364 (40%)
		STKc_MAST	834..1115	CDD:270760	207/280 (74%)
		PDZ_MAST	1502..1594	CDD:467189	53/91 (58%)
mast3a	XP_021326924.2	None