DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and mast4

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	XP_009300102.1	Gene:	mast4 / 100149322	ZFINID:	ZDB-LINCRNAG-070912-336	Length:	2570	Species:	Danio rerio

Alignment Length:	2049	Identity:	723/2049 - (35%)
Similarity:	953/2049 - (46%)	Gaps:	644/2049 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 SSSCNSSVKSCS----------GLE-------LLPTSPA--KLSIGNDSTNGSSMMRNLNLTKSS 184
            |..|::.:|:.:          |.|       |.|.|.:  |.|....|:.|||:........|.
Zfish    59 SDECSAEIKAINQGGQDEGENDGDEDEMPDNILFPPSVSFRKFSNPEVSSLGSSLALKFKRQLSE 123

  Fly   185 SGGLSGSSSSLHSRGYT--ALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLTGNYFR 247
            .|       ..|.||..  ||..|........|..|.|.||:||:|||..:||||||.||.:.
Zfish   124 DG-------RQHRRGSLGGALTGKYLLPYAQQSWSASSSETTNLVRMRSQTLGKSAPSLTASL-- 179

  Fly   248 HELTAPLPVQPPGFGASPLGGHNISRSGSCAGIGLAKHHHHHHLHGVVMRGSAGGGAGSGGGSSS 312
            .||:.|                   |.||     |.:..:...|              .|.|.||
Zfish   180 KELSLP-------------------RRGS-----LCRTSNRKSL--------------IGSGQSS 206

  Fly   313 GVAHHRLSLVTNSAAVAAAGGSRTHSPYSA----SPVDSPRLNSPMPFA-FAPIKRIASCRGVVA 372
            .:                   .|.|||.|:    ||.||||..||...| |:..:|        .
Zfish   207 AL-------------------PRPHSPLSSHTGTSPQDSPRNFSPSASAHFSFTRR--------T 244

  Fly   373 DGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAEHLKQ 437
            ||||||:||||||||||...||.:||.|||||.|:||
Zfish   245 DGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQL---------------------------- 281

  Fly   438 HCPKHCALLLAVSQKQLTPQPPKPTQLQ-PQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSA 501
                              |..|.|.:|. ..|......:
Zfish   282 ------------------PFQPTPDELHFLSKHFYTESI-------------------------- 302

  Fly   502 NSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSP-IVDNEIAVMNTLYKERFPKATQQMEERLKLFI 565
              ||....    |::| .||||||| ||.||| ..|:||.:||.:|||||||||.|||||:|..|
Zfish   303 --SGDDHR----RVTP-MRPRSRSL-SPGRSPSCCDHEIIMMNHVYKERFPKATAQMEERIKEII 359

  Fly   566 NENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKSP 630
            ..|.........|.  ::.|.|||::|:|||||.||...||||:||.||::.||||..|:.|:|.
Zfish   360 QSNSPENVLPLADG--VLSFAHHQIIELARDCLEKSRLGLITSRYFCELTDKLERLFHESTERSE 422

  Fly   631 EAAAE-LNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLG 694
            .|... :..::||:|::|:|||||||||||||:|||.||||||||||....||.|||:|||.:||
Zfish   423 SAEVTFIKELVKKILIVIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKTDIPRYIISQLG 487

  Fly   695 LNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSG 759
            |.|||:.|:.|                               |||              .|||..
Zfish   488 LTRDPLEEIAQ-------------------------------LTS--------------YDSGIA 507

  Fly   760 TATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSG 824
                 :.|:|.                                       |.::..|.:.|..|
Zfish   508 -----ETPETD---------------------------------------ESVSSHSLSAALRS- 527

  Fly   825 AQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSF 889
              :..|.|.||:::||||||||||||||:||.|:||||||||||.||:||||::|.|.|||||:|
Zfish   528 --RRKPCELDFEMIKLISNGAYGAVYLVRHKETKQRFAMKKINKQNLMLRNQIQQAFVERDILTF 590

  Fly   890 ADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGI 954
            |:|||||||||||||::|||:||||||||||.|||||:||||.||||.||||||||:||||:|||
Zfish   591 AENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGI 655

  Fly   955 VHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEV 1019
            |||||||||||:|::||||||||||||:|||::.||||||:|:.:.|:||||||.||||||||||
Zfish   656 VHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMNMTTNLYEGHIEKDAREFSDKQVCGTPEYIAPEV 720

  Fly  1020 ILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIIS 1084
            |||||||||||||:|||||||||:|||||||:|.||||...::|:|.||:.|:.| .|:|:::|:
Zfish   721 ILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEGEEAP-PADAQELIT 784

  Fly  1085 QLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDL 1149
            .||:|||.:||||..||.|:|.|::|..:||||||||||||:|||..:|||||||||.|||:| |
Zfish   785 LLLRQNPMERLGTAGGAYEVKHHQFFHSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSDRYHH-L 848

  Fly  1150 GGEDTDDTDDTPVFGSFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRAQETPAAT 1214
            ..|:.|||:|.    .||....|:....:.:|:  ..:|.|.::       ..|..:.::|...|
Zfish   849 ETEEEDDTNDE----DFNVELRQFSSSSHRFSK--VYSSLDLSR-------GQLEEKGEQTEKTT 900

  Fly  1215 VGATSTGAL---------PKLKSGMGSGSGSGSGSGSGSASHDGVVNKFLNTPQLRKLDLSSSCL 1270
            ....:..:|         |.|       |.|.....:..:...|::.||..:.::...| .|..|
Zfish   901 DSPLTVDSLSWTPDFTEIPSL-------SHSSDNESTSLSRCSGLLPKFAISAEVEDGD-GSLAL 957

  Fly  1271 KVPSTPDADYLPELLHNVT--IGNDAELRMLKHYLQQPNPGATQRMQQRHSMPPNTTTIISTPAT 1333
            :.||            .||  ||.          |.|..|                     .|:|
Zfish   958 EDPS------------KVTFSIGE----------LPQDEP---------------------DPST 979

  Fly  1334 PPPTQTQATMAATPPTATVGSFSRSTPESSQTDSDDFSPQINRKRKGVCARDILPRFSISIE--D 1396
            |..|.:.:|::        ||||...                         |.:|.....:|  :
Zfish   980 PCSTISNSTLS--------GSFSEHL-------------------------DQVPSRGDVVESLE 1011

  Fly  1397 ETISAGSSSTENMNLPREQS---PLALQHQPKSMDGSTSGSSVKHHRSRSIVKSASALGLSLMTS 1458
            .:.:|.|.:...:..|:.::   |..:...|||:  |||                   .||||
Zfish  1012 SSCNASSDTGSFLTAPKLEATDKPCIVSKVPKSV--STS-------------------ALSLM-- 1053

  Fly  1459 LDNSQLAAQLCGIQ---SPGGGGNGSSTASSRDTSPCRELSPLVTNLKPPIIIRRGPRGFGFTVH 1520
                 :...:.|:.   ||....:.||..||||:||.|:.|....:.:.||||....:.||||:.
Zfish  1054 -----IPGDVFGVSPLASPISPYSLSSDPSSRDSSPSRDSSLSGVSSRQPIIIHSSGKKFGFTLR 1113

  Fly  1521 TIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLFHTQVLQLLLSGGEHV 1585
            .||||..|:|.||::|:|..|::|.||.:|||:..|||||||||.|.||.||:|::|||..|..|
Zfish  1114 AIRVYACDSDVYTVYHMVWNVEDGGPAHKAGLKAGDLITHVNGETVHGLLHTEVVELLLKSGSKV 1178

  Fly  1586 TLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSLFRRI---------SS 1641
            .:..||.|:|||::|..:|:..:||:.     |:.|:.|:|..::|:.|:|:|.         :|
Zfish  1179 AISTTPFENTSIKTGPARRNSYRSKMV-----RRTKKPKKEKTQERRRSVFKRFAMQPSPLLHTS 1238

  Fly  1642 KRANAEMQQYSAGTSSPTTP--SARNLSPLDSSYHSSCCQSAANSSSQSTSPSSSSPNTPTGSSG 1704
            :..::..:..|:|.|.|.:|  |....||..:...:.....:..:||||:|||||:||:|.||.
Zfish  1239 RSFSSLNRSLSSGESLPGSPTHSLSPRSPTAAFRPAPDFTQSGGTSSQSSSPSSSAPNSPAGSG- 1302

  Fly  1705 SNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVPVSPTGVVPQLYQRP 1769
                                              |:                           ||
Zfish  1303 ----------------------------------HI---------------------------RP 1306

  Fly  1770 STLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHIPLSPLARTPSPS-- 1832
            ||||||..||                .|.|:          ..||||.|.||||||||||||:
Zfish  1307 STLHGLGPKL----------------PGRLR----------QGRRKSAGSIPLSPLARTPSPTPQ 1345

  Fly  1833 PLPSSPTRSPSPLAFPLVGHQPGASNTTQSY-----SPGSTLPTLQTAVNANTKKAGFARTKSAE 1892
            |.|:||.||||    ||:.|..|:|.|:|.:     ||    ||:...:         .|.||||
Zfish  1346 PQPTSPQRSPS----PLLTHTVGSSKTSQPFPAKMHSP----PTIVRHM---------VRPKSAE 1393

  Fly  1893 -PSSPLLRRALSPDRLHPRSAETKISPLC---------------------------------CSP 1923
             |.||||:|..|.::|.|..|..| ..||                                 |.|
Zfish  1394 PPRSPLLKRVQSEEKLSPSYAGDK-KHLCTRKHSLEVTQEESQGEASSKGENVQPCIEESTSCDP 1457

  Fly  1924 P------------IKQPTHQRV---------------------------------VTTTWRSTPG 1943
            |            :|:|..::|                                 ...|.:...|
Zfish  1458 PTITRVRPAEQGCLKRPVTRKVGRQESVEELDKEKLKAKVVVKRQDWPERRESMPKQDTVQDVEG 1522

  Fly  1944 GSASGAGGAVLGAPSVQPLQLVPAASEESQRQTAMATVVSTTAAGTDP----SATAVVTLANCEP 2004
            .:|......||..|||:| |::.:.|.:.....::..|:...   .:|    |....||..:|..
Zfish  1523 PTAEDKEWGVLTRPSVRP-QILESGSLDKSTNASLKDVLYKK---LNPRVCESIAESVTTGDCAS 1583

  Fly  2005 LPRIAEEKDSPT---STQDSSSVSEGFMPAIEEF 2035
            .  ::|...||:   ..|.|.|:.||..|...:|
Zfish  1584 F--LSENIRSPSCQAERQMSWSMKEGNKPERLDF 1615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	154/361 (43%)
		STKc_MAST	834..1115	CDD:270760	207/280 (74%)
		S_TKc	835..1110	CDD:214567	205/274 (75%)
		PDZ_signaling	1506..1587	CDD:238492	44/80 (55%)
mast4	XP_009300102.1	DUF1908	223..495	CDD:286070	154/361 (43%)
		STKc_MAST	535..815	CDD:270760	207/280 (74%)
		S_TKc	536..810	CDD:214567	205/274 (75%)
		PDZ_signaling	1103..1180	CDD:238492	41/76 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010