DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and lats2

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	XP_012811721.1	Gene:	lats2 / 100124721	XenbaseID:	XB-GENE-994907	Length:	1117	Species:	Xenopus tropicalis

Alignment Length:	1252	Identity:	291/1252 - (23%)
Similarity:	445/1252 - (35%)	Gaps:	403/1252 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 DQEAAAAAAALAAASSSCNSSVKSCSGLELL------------PTSPAKLSIGNDSTNGSSMMRN 177
            |||.|..|.. ...|.|..::::..|.:..|            .|||.|::..|..::
Frog   114 DQEMAVRALK-QTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKVTPPNSVSH------- 170

  Fly   178 LNLTKSSSGGLSGSSSSLHSRGYTALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLT 242
                :::..|.:.:.|..|.      :...:|:.     ...:.|.:|:|        ...|
Frog   171 ----RANFEGSNETFSPYHP------VNNAAYEG-----PGFAAEGANVL--------SEVP--- 209

  Fly   243 GNYFRHELTAPLPVQPPGFGASPL---GGHNISRSGSCAGIGLAKHHHHHHLHGVVMRGSAGGGA 304
            ..|..:.|::|.|....|....||   |.||
Frog   210 RQYMDYLLSSPQPATLNGPSQRPLPVVGAHN---------------------------------- 240

  Fly   305 GSGGGSSSGVAHHRLSLVTN--SAAVAAAGGSRTHSPYSASPVDSPRLNSPMPFAFAPIKRIASC 367
                   |.|:|.:...|||  ||.:....||. :||  ..|:.:|..:|...::...:.
Frog   241 -------SPVSHQQKGYVTNAESAVINYVIGSH-NSP--GLPIQTPHASSSPHYSRQHMM----- 290

  Fly   368 RGVVADGRRWSVASLPS--------SGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAA 424
              |..|...:||...||        .||...|.:|...:...:..|| .:.|.
Frog   291 --VQGDPMGYSVQRTPSFQNKMQQDGGYVNIPQTSPGHAYTQAPSGL-YMPHT------------ 340

  Fly   425 VAAGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQ 489
                     |.||                  ..||
Frog   341 ---------HHKQ------------------TSPP------------------------------ 348

  Fly   490 AGGGAANGGSSANSSGSSAMQVGGRMSPY---FRPRSRSLSSPSRSPIVDNEIAVMNTLYKERFP 551
                            |..|.|..|.|||   |....::|.:|||           |:|..:.:.
Frog   349 ----------------SHQMHVISRGSPYGNEFSDTPQALLTPSR-----------NSLNMDLYD 386

  Fly   552 KATQQMEERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLH----------------K 600
            ..                    |::::|||            .||.|.                .
Frog   387 IG--------------------NAWQNSQP------------CRDSLQGPGLDSSPRQHVSFRPD 419

  Fly   601 SEAKLITSQYFYELSENLERLLVETKEKSPEAAAEL-NGVIKKLLLIISRPARLLECLEFDPQEF 664
            |:....|:. |....:..:.::.:|....|:::... |.|.......|.:|.:.:.....:||..
Frog   420 SQVPSRTNS-FNNHQQQKQVVMRQTPPNKPDSSMTAPNTVTTVTSTHILQPVKSMRVARPEPQTA 483

  Fly   665 Y-----------------ELLEAAEGHAKAMPVIKA---DI-----------PQYIIHKLGLNRD 698
            .                 :.:|..|.|..:|....|   |:           |.|..|.| |..:
Frog   484 VGPSHPSWLAAQAQKLETQKVEMVEPHTSSMGAANAYGMDVGYGNQDMRFPPPPYPKHLL-LQNN 547

  Fly   699 PIAELQQELRETQQMC---------SEQV---TVDADPLHPGGSLLLNSPLTSAA----KQLSSL 747
            |      |..|...:|         ||.|   .||.....|..|.:..:|....:    ||:.:.
Frog   548 P------EQHELNALCKGMDQNLRVSENVPCGPVDEANGEPKPSKVSKTPKVVKSGKDKKQIQTS 606

  Fly   748 AL-------DAIAMDSGSGTATP-------QQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAV 798
            .:       |....:|...:.:|       :|..:..:.|.....:..|.:.|...| .|...|:
Frog   607 PVPVRKNSRDEEKRESRIKSYSPFAYKFYMEQHVENVLKTYQQKINRRLQLEQEMAE-AGLCEAI 670

  Fly   799 GGGSSSKVAGAEGITGGSAATATGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAM 863
            .......:...|         :..:..::....::.|..:|.:..||:|.|.|.....|:..:||
Frog   671 QEQMRKILYQKE---------SNYNRLKRAKMDKSLFVKIKTLGIGAFGEVCLASKVDTKALYAM 726

  Fly   864 KKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIG 928
            |.:.|.:::.||||..|.||||||:.|||.:||.:|.||:.|..|..||:|:.|||..:||..:.
Frog   727 KTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME 791

  Fly   929 PLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLY- 992
            ..|..:||||.||..||:|.:|..|.:|||:||||:||...||||||||||. .|......:.|
Frog   792 VFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLC-TGFRWTHNSKYY 855

  Fly   993 --------------EGYIDSETRQFSDK------------------QVYGTPEYIAPEVILRQGY 1025
                          |.:.|....:..|:                  .:.|||.||||||:||:||
Frog   856 QKGNHARQDSMEPSELWDDVSNCRCGDRLKTLEQRAKRQHHRCLAHSLVGTPNYIAPEVLLRKGY 920

  Fly  1026 GKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQ----AEAKDIISQL 1086
            .:..||||:|:||:|.|:|..||......|    |....|.|.::...|.|    .||.::|:.|
Frog   921 TQLCDWWSVGVILFEMLVGQPPFLASNPTE----TQLKVIHWENTLHIPSQINLSPEATNLITAL 981

  Fly  1087 LQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLR-QKAEFVPQLSHDDDTSYFDTRMDRYN--HD 1148
            . ....|||| ::|..|:|.|.:|:.||::|.:| |.|.:||::||..|||.||. ::..|  :|
Frog   982 C-CGAEDRLG-RNGPDEIKAHPFFISMDFSSDIRHQPAPYVPKISHPMDTSNFDP-VEEENPCND 1043

  Fly  1149 LGGEDTDDTDDTPVFGSFNSYTPQYRKQHYSWSR----HATPTSTDGAKPTGPPPLSSLPSRAQE 1209
            .|  |:..|.|| :..|.|.:| ::....:::.|    |..|...       |.|.....|..:|
Frog  1044 SG--DSTVTWDT-LMSSGNKHT-EHAFYEFTFRRFFDDHGYPFRY-------PKPSKLETSSCEE 1097

  Fly  1210 TPAATVGAT--STGALP 1224
            |......|:  |.|..|
Frog  1098 TEEEDKNASRESEGCQP 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	65/416 (16%)
		STKc_MAST	834..1115	CDD:270760	122/317 (38%)
		S_TKc	835..1110	CDD:214567	120/311 (39%)
		PDZ_signaling	1506..1587	CDD:238492
lats2	XP_012811721.1	UBA_LATS2	102..142	CDD:270581	8/28 (29%)
lats2	XP_012811721.1	PKc_like	696..1075	CDD:419665	147/390 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910