DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dop and mast2

DIOPT Version :9

Sequence 1:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster
Sequence 2:	XP_009300769.1	Gene:	mast2 / 100001267	ZFINID:	ZDB-GENE-050309-150	Length:	1934	Species:	Danio rerio

Alignment Length:	2226	Identity:	776/2226 - (34%)
Similarity:	1018/2226 - (45%)	Gaps:	672/2226 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 PVPKRHLSTANLSRIRPQSSYSARVLIFDDSDQEAAAAAAALAAASSSCNSSVKSCSGLELLPTS 158
            |:..|.||..:||....::... |.|..|||....::.|..|              :|.:|||
Zfish    34 PLLFRKLSNPDLSPAAGKTKLQ-RQLSQDDSRGRRSSMAGIL--------------TGKQLLP-- 81

  Fly   159 PAKLSIGNDSTNGSSMMRNLNLTKSSSGGLSGSSSSLHSRGYTALLRKISYQQHTNSLRAVSGET 223
                                 |:.|..||:|                ::::||||       ||.
Zfish    82 ---------------------LSSSMHGGVS----------------QLAWQQHT-------GEP 102

  Fly   224 SNLLRMRHSSLGKSAPCLTGNYFRHELTAPLPVQPPGFGASPLGGHNISRSGS-CAGIGLAKHHH 287
            :||:|||..|.|:|||.||...  .||:.|                   |.|| |.
Zfish   103 NNLVRMRSQSFGQSAPSLTAGL--KELSLP-------------------RRGSFCR--------- 137

  Fly   288 HHHLHGVVMRGSAGGGAGSGGGSSSGVAHHRLSLVTNSAAVAAAGGSRTHSPY----SASPVDSP 348
                                       ..:|.||:..|:.....  .|.|||.    .:||:|||
Zfish   138 ---------------------------TSNRKSLIVTSSTSPTL--PRPHSPLHGHPGSSPLDSP 173

  Fly   349 RLNSP---MPFAFAPIKRIASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLA 410
            |..||   ..|:|.| .|....|....||||||:||||||||||...||.:||.|||||.|:||
Zfish   174 RNFSPNTAAHFSFVP-ARSHGHRADRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQL- 236

  Fly   411 HNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACV 475
                                                           |.:||
Zfish   237 -----------------------------------------------PFQPT------------- 241

  Fly   476 NCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSPI-VDNEI 539
              ..||...               :.:.|..|.....||.||..||||||| ||.|||| .|:||
Zfish   242 --ADELHFL---------------TKHFSSESITDEDGRRSPAMRPRSRSL-SPGRSPISFDHEI 288

  Fly   540 AVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAK 604
            .:||.:|||||||||.|||.||..||:.:.........|.  ::.|:||||:|::||||.||...
Zfish   289 VMMNHVYKERFPKATAQMEVRLADFISSSAPEKVMPLADG--VLSFIHHQVIELSRDCLDKSREG 351

  Fly   605 LITSQYFYELSENLERLLVETKEKSPEAAAE-LNGVIKKLLLIISRPARLLECLEFDPQEFYELL 668
            ||||:|||||.||||:|..:..|:|...... :..::|||::||:|||||||||||||:|||.||
Zfish   352 LITSRYFYELQENLEKLHQDAHERSESGEVTFVTQLVKKLMIIIARPARLLECLEFDPEEFYHLL 416

  Fly   669 EAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLL 733
            ||||||||....||:|||:|||.:|||.|||:.|:
Zfish   417 EAAEGHAKEGQGIKSDIPRYIISQLGLTRDPLEEM------------------------------ 451

  Fly   734 NSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAV 798
                    .||||       .|||:        |:||....|:..|....:..:..:.
Zfish   452 --------AQLSS-------YDSGN--------PETPETETDSTDSRGATVQPLQPQP------- 486

  Fly   799 GGGSSSKVAGAEGITGGSAATATGSGAQQP---SPQENDFDIVKLISNGAYGAVYLVKHKTTRQR 860
                                      ..||   :|:|.||:.:|||||||||||:||:||.||||
Zfish   487 --------------------------QPQPKTKTPREEDFETIKLISNGAYGAVFLVRHKETRQR 525

  Fly   861 FAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLK 925
            ||||||||.|||||||::|.|.|||||:||:|||||||:|||||::|||:||||||||||.||||
Zfish   526 FAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLK 590

  Fly   926 NIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATN 990
            :||.||.||||.||||||||:||||:||||||||||||||||::||:|||||||||:|||||.||
Zfish   591 HIGALPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHVKLTDFGLSKIGLMSLTTN 655

  Fly   991 LYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEE 1055
            ||||:|:.:||:|.||||.|||||||||||||||||||||||:||:||||||:||.||||:|.||
Zfish   656 LYEGHIEKDTREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGVILYEFLVGCAPFFGDTPEE 720

  Fly  1056 LFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLR 1120
            ||...::|:|.||:.:: .:..:|:|:||:||:|||.:||||.| |.|:|:|.:|..:|||||||
Zfish   721 LFGQVISDEIIWPEGDE-ALPPDAQDLISKLLRQNPLERLGTGS-AFEVKQHRFFTDLDWNSLLR 783

  Fly  1121 QKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDT--DDTPVFGSFNSYTPQYRKQHYSWSRH 1183
            |||||:|||..:|||||||||.|||:| :..|:.|||  ||......|:|.:|::.|.:.|..|
Zfish   784 QKAEFIPQLESEDDTSYFDTRSDRYHH-VDSEEEDDTNDDDHLEIRQFSSCSPRFSKVYSSMER- 846

  Fly  1184 ATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGATS------TGALPKLKSGMGSGSGSGSGSGS 1242
               .|....|.|.||...||.....|...:..|..|      .|:...|:..:.....|.:.|.|
Zfish   847 ---LSLHEEKRTPPPTKRSLSEEGGERIDSLSGLKSRDRSWLVGSPEILRKRLSVSESSHTESDS 908

  Fly  1243 GS--ASHDGVVNKFLNTPQLRKLDLSSSCL---KVP-STPDADYLPELLHNVTIGNDAELRMLKH 1301
            ..  .......:..:..|:........||:   |.| ..|..|.||:.:..:.:  :.|||
Zfish   909 SPPLTVRRRCCSAIIEMPRFAISSEEDSCVGSRKTPVRGPRGDDLPQAIPELPV--ERELR---- 967

  Fly  1302 YLQQPNPGATQRMQQRHSMPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRSTPESSQTD 1366
                                     :..:|.||..|.:|.:.:    |.|.||
Zfish   968 -------------------------LDESPTTPGSTSSQISQS----TLTPGS------------ 991

  Fly  1367 SDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQH-QPKSMDGS 1430
                            :.|:|.|         .|..|:.....:.||..|.||.:. :.:.:.|.
Zfish   992 ----------------SGDVLDR---------ASRYSAEVSENSTPRAISDLAARRARHRLLSGD 1031

  Fly  1431 TSGSSVKHHRSR---SIVKSASALGLSLMTSLDN---SQLAAQLCGIQSPGGGGNGSSTASSRDT 1489
            |.     .|.||   .::|||||..||||...|:   |.||       ||....:.||..||||:
Zfish  1032 TD-----KHTSRPLSKVIKSASATTLSLMIPADHHGASPLA-------SPMSPHSLSSNPSSRDS 1084

  Fly  1490 SPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRP 1554
            ||.|:|||.|.::||.|||.|..:.:|||:..||||.||||.||:||:|..|::|.||.|||||.
Zfish  1085 SPSRDLSPAVCSVKPAIIIHRAGKKYGFTLRAIRVYMGDTDIYTVHHMVWHVEDGGPAHEAGLRE 1149

  Fly  1555 ADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQ 1619
            .|||||||||.|.||.||:|::|:|..|..|::.|||.|:|||:.|..::...:||:|::  |::
Zfish  1150 GDLITHVNGEPVHGLVHTEVVELILKSGSKVSISATPFENTSIKVGPARKTSYKSKMARR--NKR 1212

  Fly  1620 KKQTKREHDKKRKTSLFRRI--------SSKRANAEMQQYSAGTSSPTTPSARNLSPLDSSYHSS 1676
            .| |:...|.|::.||||:|        :|:..::..:..|:|.|.|.:|:  ::||  .|....
Zfish  1213 TK-TREGQDSKKRNSLFRKITKQATLLHTSRSLSSLNRSVSSGESVPGSPT--HMSP--RSPTQG 1272

  Fly  1677 C------CQSAANSSSQSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLV 1735
            |      ..|...:||||:|||||.||:|..|
Zfish  1273 CRSTPDSAHSVGGNSSQSSSPSSSVPNSPASS--------------------------------- 1304

  Fly  1736 LLPHVGAVVGSNPTSVGNVPVSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLK 1800
                            |.:             |||:||||..||..         ...:|
Zfish  1305 ----------------GQI-------------RPSSLHGLAPKLQR---------QYRSP----- 1326

  Fly  1801 TLHTTNNNSLPNRRKSVGHIPLSPLARTPSPSPLPSSPTRSPSPL-AFPLVGHQPGASNTTQSYS 1864
                        ||||.|:||||||||||||:|..:||.|||||| :..|:....|.|...:.:|
Zfish  1327 ------------RRKSAGNIPLSPLARTPSPTPQSTSPQRSPSPLPSHGLITSSIGQSFPVKLHS 1379

  Fly  1865 PGSTLPTLQTAVNANTKKAGFARTKSAE-PSSPLLRRALSPDRL-----------HPRSAETKIS 1917
            .    |.|...:         :|.|||: |.||||:|..|.::|           .|.||..|..
Zfish  1380 S----PPLVRQI---------SRPKSADPPRSPLLKRVQSAEKLAASLSSSSSSPSPSSAADKKL 1431

  Fly  1918 PLCCSPP---------------IKQPTHQRVVTTTWRSTPGGSASGAGGAVLGAPSVQ------- 1960
            |:..|..               .:.|:.|.:..:...:..||..|.|....|...||:
Zfish  1432 PVGASRKHSLDTSHSEFKKEMLQRDPSLQSLQESASETLMGGRVSPAEKGSLQKSSVRKLGRQEG 1496

  Fly  1961 ------PLQLVPAAS--------------EESQRQTAMATVVST---TAAGTD------------ 1990
                  .|.|||..|              |..|:|.|:..|.|:   |..|::
Zfish  1497 PESGTGTLGLVPGKSKLKDKLSAIRAERRESLQKQDAIHEVDSSEDETDEGSEDSQDGRRTCYAP 1561

  Fly  1991 PSATAVVTLANCEPLPRIAEEKDSPTSTQDSSSVSEGFMPAI---EEFAEGESSSSPTQTLEKPT 2052
            ||.....|.....|..........||.....|:|:....|.:   .:.....::.|.|||.....
Zfish  1562 PSHVLRPTTVMASPHTIRMGPAAPPTLGLFPSTVAPPCSPQLIRGLQIQNQSTTQSQTQTSTSQP 1626

  Fly  2053 KVKATEQPEMEP-----------AGKSKKVDQG-------------------------------- 2074
            ...|.:.||.:|           ...|||..|.
Zfish  1627 AQAAVKPPEQKPITSVKDSSSTIIDDSKKQSQAQDIQSRPSPHQPSPLSSTFSTQGSAFTSVSKD 1691

  Fly  2075 ---KTTTP-----GTPK-TKPHN--SGCKTSMTTTKPASPSVTISTAP---------RKDTSAVT 2119
               |.|||     .||| ::|.:  || :|..:||...:....::|.|         ..|.....
Zfish  1692 PFVKPTTPPLDPRRTPKMSEPRSKTSG-RTDSSTTSGVARDTPVATTPTGGITKEMKEADNRRQA 1755

  Fly  2120 GGGSSGSGGSAATSAA 2135
            ...::.|..:|.|||:
Zfish  1756 AAAAAASAAAATTSAS 1771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	159/362 (44%)
		STKc_MAST	834..1115	CDD:270760	205/280 (73%)
		S_TKc	835..1110	CDD:214567	203/274 (74%)
		PDZ_signaling	1506..1587	CDD:238492	48/80 (60%)
mast2	XP_009300769.1	DUF1908	169..450	CDD:286070	159/362 (44%)
		STKc_MAST	499..778	CDD:270760	205/280 (73%)
		S_TKc	500..773	CDD:214567	203/274 (74%)
		PDZ_signaling	1101..1182	CDD:238492	48/80 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589137
Domainoid	1	1.000	440	1.000	Domainoid score	I524
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1041	1.000	Inparanoid score	I260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm24417
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.850