DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCCRO and dcn-1

DIOPT Version :9

Sequence 1:	NP_001246770.1	Gene:	SCCRO / 39685	FlyBaseID:	FBgn0036510	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_497866.2	Gene:	dcn-1 / 175556	WormBaseID:	WBGene00010428	Length:	295	Species:	Caenorhabditis elegans

Alignment Length:	306	Identity:	105/306 - (34%)
Similarity:	153/306 - (50%)	Gaps:	40/306 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 INKLKSSTHRDKVKKFISLTHTGEQTAIFCLQQNDWKFELASDNYFQNPEYY-----YRELDRKR 69
            :|:|||. .:.|:::|:..|...|..::..|.:.:|..|.|...||.||..:     ...:||..
Worm     1 MNRLKSD-QKTKLRQFVQWTQVTEAVSLNFLAKANWNIEYAMTLYFDNPNLFAGSTPQPSVDRSN 64

  Fly    70 IEQLFMRYRDPSDPL---KIGSQGVIHFLEDLDLKPDSKLVLIIAWKFHAEVQCEFSRDEFINGM 131
            ||:||.:|.||.|.:   ::|..|:...|.||..:...:.||::||||.|:.|||||.||::.||
Worm    65 IERLFNQYVDPKDKVGEKRMGPHGINRLLTDLGYEATDRRVLVLAWKFTAQTQCEFSLDEWVKGM 129

  Fly   132 CDLGIDSIDKLKTKLPILEQEL-NDAGKFKDFYHFTFNYAKDPGQKGIDLEMAIAYWCIVLSGRF 195
            ..|..|::..|:.::..:...| :|..||.:.|.|.|||||....:.:|||.||..|.::...|.
Worm   130 TALQADTVQNLRQRIDSINSGLESDKAKFHELYLFAFNYAKSAACRNLDLETAICCWDVLFGQRS 194

  Fly   196 KFLDIWCQFLEEKHKRA--------------------ISRDTWNLLLDFATNIDDRMSNYDSEGA 240
            ..:..|..||..:...|                    ||||||||..||.......:|:||.|||
Worm   195 TIMTQWIDFLWAQENAAASRLAQNVGASNAKQFKSVWISRDTWNLFWDFILLSKPDLSDYDDEGA 259

  Fly   241 WPVLIDDFVEWCQENDHLKEDSSPASGYQQQSSASSSSQKNISSAY 286
            ||||||.||::|:||          ..|.:..:||:..|....|.|
Worm   260 WPVLIDQFVDYCREN----------LNYPKPGNASNDQQMETPSYY 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCCRO	NP_001246770.1	UBA_like_SF	11..58	CDD:304366	14/46 (30%)
SCCRO	NP_001246770.1	Cullin_binding	141..252	CDD:281545	47/131 (36%)
dcn-1	NP_497866.2	UBA_DCNL	7..48	CDD:270535	10/41 (24%)
dcn-1	NP_497866.2	Cullin_binding	140..271	CDD:281545	47/130 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167557
Domainoid	1	1.000	83	1.000	Domainoid score	I5335
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	181	1.000	Inparanoid score	I2649
Isobase	1	0.950	-	0	Normalized mean entropy	S1522
OMA	1	1.010	-	-		QHG53724
OrthoDB	1	1.010	-	-		D1418097at2759
OrthoFinder	1	1.000	-	-		FOG0000501
OrthoInspector	1	1.000	-	-		oto20758
orthoMCL	1	0.900	-	-		OOG6_102228
Panther	1	1.100	-	-	LDO	PTHR12281
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2084
SonicParanoid	1	1.000	-	-		X1511
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890