Protein Alignment CG7739 and ITFG1

DIOPT Version :10

• Sequence 1: NP_648776.1
• Gene: CG7739 / 39684
• FlyBaseID: FBgn0036509
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_110417.2
• Gene: ITFG1 / 81533
• HGNCID: 30697
• Length: 612
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 237/639 - (37%)
• Similarity: 345/639 - (53%)
• Gaps: 91/639 - (14%)

  Fly     6 LVLGL-LLALG----NLIHASNITDKVFADIKEGIVAAFGDFNSDELTDVFVIRDGMKRLQILFG 65
            |:.|| ||.:|    ..:|  |:|.::|.....|.:|||||.|||:.||:||:|: ...|.:...
Human    17 LLAGLALLGVGPVPARALH--NVTAELFGAEAWGTLAAFGDLNSDKQTDLFVLRE-RNDLIVFLA 78

  Fly    66 HYTEPLLKLGPDCQYGDKT----IVSVIPGDFDGDALMDVLVNLKGKDEETYEVH--INWGNTTE 124
            ....|..|  |..:...|.    |.||:|||:|||:.||||:....|:....|:.  |.||....
Human    79 DQNAPYFK--PKVKVSFKNHSALITSVVPGDYDGDSQMDVLLTYLPKNYAKSELGAVIFWGQNQT 141

  Fly   125 LKCSNKSLF--TSKGEVMALDFNRDMIIDLYGLDSAERRTFWIFNSSRLPPEAV------HQAEP 181
            |..:|.::.  |.:.|.:.:|||.|:|.|::|          |.|.|..|...:      |.|..
Human   142 LDPNNMTILNRTFQDEPLIMDFNGDLIPDIFG----------ITNESNQPQILLGGNLSWHPALT 196

  Fly   182 TEFKENLSIPNANAYLDLNGDFLADLFLQTKSS------YEIWHGINERDKQENFSYQYQIKFQP 240
            |..|  :.||:::|::||..||.|||||.|.::      :|||..::     .|||.. .|..:|
Human   197 TTSK--MRIPHSHAFIDLTEDFTADLFLTTLNATTSTFQFEIWENLD-----GNFSVS-TILEKP 253

  Fly   241 IGGNDYYIGQAVFMDFELKGVQNIVVPFCILSNCRNSSI-MVHDG--------TDFRNLHVNFRD 296
              .|...:||:.|.||:..|..:.::|.|...||:.|:| :|..|        .||.|
Human   254 --QNMMVVGQSAFADFDGDGHMDHLLPGCEDKNCQKSTIYLVRSGMKQWVPVLQDFSN------- 309

  Fly   297 PQGVTWAFVPPVSDDVYLR---TITARSGDFNLDGYPDLLVTLQPLNVDKPVMQTFLLENVPCTT 358
             :|..|.|||.|.:.....   .||...||:|:|||||.||.|:  |......|.||||||||..
Human   310 -KGTLWGFVPFVDEQQPTEIPIPITLHIGDYNMDGYPDALVILK--NTSGSNQQAFLLENVPCNN 371

  Fly   359 CN-KPLKRTFEVRWNALSPMG--NNTVAGAFYDFYQDGVLDVILIRKD-GKGKYQPLAFRNTLDY 419
            .: :..:|.|:|.|. |:.:.  .:.:...|:|.|:||:||::::.|. .|..:.....:|..:.
Human   372 ASCEEARRMFKVYWE-LTDLNQIKDAMVATFFDIYEDGILDIVVLSKGYTKNDFAIHTLKNNFEA 435

  Fly   420 DANFVKVIVLTGLDNKQNPERRTPLGRKKRTYGTNLPGPRITYSTTTQDGDQQCGSSVQLPQASY 484
            ||.|||||||:||.:...|.:.||       :|.|.|||.|.|:|...:|..:.||:.||.|:::
Human   436 DAYFVKVIVLSGLCSNDCPRKITP-------FGVNQPGPYIMYTTVDANGYLKNGSAGQLSQSAH 493

  Fly   485 FALQLPYTCFGLGRTPNFVDQLTVGL----GSK---LRNWTQLIPNSQIIVVPKPLNEPSHWKAQ 542
            .||||||...||||:.||:|.|.||:    |.|   .:.||.:|||||:||:|.|.|.|..|.|:
Human   494 LALQLPYNVLGLGRSANFLDHLYVGIPRPSGEKSIRKQEWTAIIPNSQLIVIPYPHNVPRSWSAK 558

  Fly   543 LFVTPSKLILMSVVALGGTCLVIVFIILVLYIKEKREDKQERLQESHRFHFDAM 596
            |::|||.::|::.:||.|.|:.|:.||.:|:.:||:.|.:|:.||:||||||||
Human   559 LYLTPSNIVLLTAIALIGVCVFILAIIGILHWQEKKADDREKRQEAHRFHFDAM 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7739	NP_648776.1	FG-GAP_3	41..103	CDD:433275	26/65 (40%)
ITFG1	NP_110417.2	FG-GAP_3	55..118	CDD:433275	26/65 (40%)
		FG-GAP, atypical	258..293		12/34 (35%)
		FG-GAP_3	266..349	CDD:433275	30/90 (33%)