Protein Alignment AGO2 and AGO1

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_849784.1
• Gene: AGO1 / 841262
• AraportID: AT1G48410
• Length: 1050
• Species: Arabidopsis thaliana
• Alignment Length: 1084
• Identity: 336/1084 - (30%)
• Similarity: 486/1084 - (44%)
• Gaps: 192/1084 - (17%)

  Fly   206 QQRPPGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQQGGHQQGRQGQ 270
            ::|.....:||...|         .|.:|...||   ||..|.||:|| ..||.|||.
plant     4 KRRTDAPSEGGEGSG---------SREAGPVSGG---GRGSQRGGFQQ-GGGQHQGGR------- 48

  Fly   271 EGGYQQRPPGQQQGGHEQGRQGQEGGYQQRPSGQQQ-GGHQQGRQGQEGGYQQRPSGQQQGG--H 332
              ||..:|   |||    ||.|:  ||.|.|..||| ||.|:        ||    |:.:||  |
plant    49 --GYTPQP---QQG----GRGGR--GYGQPPQQQQQYGGPQE--------YQ----GRGRGGPPH 90

  Fly   333 QQGRQGQEGGYQQRPSGQQQGGHQQG-----RQGQEGGYQ---QRP------PGQQPNQTQSQGQ 383
            |.||.|..||   |..|...|..|:.     .|.....||   .:|      |.|.|..|....|
plant    91 QGGRGGYGGG---RGGGPSSGPPQRQSVPELHQATSPTYQAVSSQPTLSEVSPTQVPEPTVLAQQ 152

  Fly   384 YQ----SRGPPQQQQAAPLP-------LPPQPAGSIKRGTIGKPGQVGINYL-----DLDLSKMP 432
            ::    .:|.| .|...|:|       .|.:|.    :|..||...|..|:.     |.||
plant   153 FEQLSVEQGAP-SQAIQPIPSSSKAFKFPMRPG----KGQSGKRCIVKANHFFAELPDKDL---- 208

  Fly   433 SVAYHYDVKIMPERPKK-----FYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVT 492
               :||||.|.||...:     ..:|..:.:|...||..:.||||:.|.|:...||.||:...:.
plant   209 ---HHYDVTITPEVTSRGVNRAVMKQLVDNYRDSHLGSRLPAYDGRKSLYTAGPLPFNSKEFRIN 270

  Fly   493 VTD--------RNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLAS-PCH 548
            :.|        |..|..:..|::.    :..||..|..::..:..|.|..|:|.:::||.. |..
plant   271 LLDEEVGAGGQRREREFKVVIKLV----ARADLHHLGMFLEGKQSDAPQEALQVLDIVLRELPTS 331

  Fly   549 N-KAIRVGRSFFKMSDPNNRHELDDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPM 607
            . :.|.|||||:. .|...:..|.||.|:..|.||:.    ||     .||:|:|..:|..:.|:
plant   332 RIRYIPVGRSFYS-PDIGKKQSLGDGLESWRGFYQSI----RPTQMGLSLNIDMSSTAFIEANPV 391

  Fly   608 IEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETF 672
            |:::... |...|::....|..|..::..|||:.|..|...:.:   |.||::||:.......||
plant   392 IQFVCDL-LNRDISSRPLSDADRVKIKKALRGVKVEVTHRGNMR---RKYRISGLTAVATRELTF 452

  Fly   673 EHDGKKV--TIASYFH-SRNYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVA 734
            ..|.:..  ::..||| :..:.::..||.||.||:|.:...||:|:|.|.|||..:::....|:.
plant   453 PVDERNTQKSVVEYFHETYGFRIQHTQLPCLQVGNSNRPNYLPMEVCKIVEGQRYSKRLNERQIT 517

  Fly   735 NMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHS---KR 796
            .::|........|::.|:..:|...:..|.....|||:|:.....|..|:|.||.::||.   :.
plant   518 ALLKVTCQRPIDREKDILQTVQLNDYAKDNYAQEFGIKISTSLASVEARILPPPWLKYHESGREG 582

  Fly   797 FTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLN---------------DFGNL 846
            ..:.:.|.|.|...|.:                ..|...|:..:|               :...:
plant   583 TCLPQVGQWNMMNKKMI----------------NGGTVNNWICINFSRQVQDNLARTFCQELAQM 631

  Fly   847 IISQGKAVNIS-LDSDVTYRPFTDDERSLDTIFADL--KRSQH---DLAIVIIPQFRIS-YDTIK 904
            ....|.|.|.. :...|:.|| ...|:.|.|.:.|.  |.||.   ||.|||:|....| |..:|
plant   632 CYVSGMAFNPEPVLPPVSARP-EQVEKVLKTRYHDATSKLSQGKEIDLLIVILPDNNGSLYGDLK 695

  Fly   905 QKAELQHGILTQCIKQFTVERKCNNQTIGNILLKINSKLNGINHKIKD--DPRLPMMKN--TMYI 965
            :..|.:.||::||.....| .|.:.|.:.|:.||||.|:.|.|..:.|  ..|:|::.:  |:..
plant   696 RICETELGIVSQCCLTKHV-FKMSKQYMANVALKINVKVGGRNTVLVDALSRRIPLVSDRPTIIF 759

  Fly   966 GADVTHPSPDQREIPSVVGVAASHD-PYGASYNMQYRLQRGALEEIEDMF-------------SI 1016
            |||||||.|.:...||:..|.||.| |....|......|....|.|:|:|             .:
plant   760 GADVTHPHPGEDSSPSIAAVVASQDWPEITKYAGLVCAQAHRQELIQDLFKEWKDPQKGVVTGGM 824

  Fly  1017 TLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACD--KVGCKPKICCVIVVKR 1079
            ..|.|..::......|..||:||||||:|||.::...||..|::||.  :.|.:|.:..|:|.||
plant   825 IKELLIAFRRSTGHKPLRIIFYRDGVSEGQFYQVLLYELDAIRKACASLEAGYQPPVTFVVVQKR 889

  Fly  1080 HHTRFFPS--GDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGN 1142
            ||||.|..  .|..:.::..|:.||||||..|.||.|..|::.||..||||::|..|:|:.:..|
plant   890 HHTRLFAQNHNDRHSVDRSGNILPGTVVDSKICHPTEFDFYLCSHAGIQGTSRPAHYHVLWDENN 954

  Fly  1143 LDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYL 1186
            ...|.||.||.|||:.:.||.||||...|||.|||.|.|.|.|:
plant   955 FTADGLQSLTNNLCYTYARCTRSVSIVPPAYYAHLAAFRARFYM 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	19/79 (24%)
		ArgoL1	554..601	CDD:462567	19/51 (37%)
		PAZ	605..719	CDD:239207	33/116 (28%)
		Piwi_ago-like	764..1186	CDD:240015	157/468 (34%)
AGO1	NP_849784.1	Gly-rich_Ago1	79..172	CDD:463691	29/108 (27%)
		PLN03202	163..1050	CDD:215631	271/879 (31%)