DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and AGO10

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_001190464.1	Gene:	AGO10 / 834403	AraportID:	AT5G43810	Length:	988	Species:	Arabidopsis thaliana

Alignment Length:	949	Identity:	270/949 - (28%)
Similarity:	424/949 - (44%)	Gaps:	139/949 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 GRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQPNQTQSQ-------------GQYQS 386
            ||:..:|....|||.:                .::||  .|:||.|.             .....
plant    73 GRKSDQGDVCMRPSSR----------------PRKPP--PPSQTTSSAVSVATAGEIVAVNHQMQ 119

  Fly   387 RGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYH-YDVKIMPERPKKF 450
            .|..:....||.|         ..||:|....|..|:.   |:.:|:...: |||.|.||...|.
plant   120 MGVRKNSNFAPRP---------GFGTLGTKCIVKANHF---LADLPTKDLNQYDVTITPEVSSKS 172

  Fly   451 YRQAF-----EQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVTDR-----NG--RTLRY 503
            ..:|.     ..::...||..:.||||:.|.|:..:||...:...|.:.|.     ||  |...|
plant   173 VNRAIIAELVRLYKESDLGRRLPAYDGRKSLYTAGELPFTWKEFSVKIVDEDDGIINGPKRERSY 237

  Fly   504 TIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNNRH 568
            .:.||..  :..::..|..::..:..|.|..|:|.:::||......:...||||||. .|.....
plant   238 KVAIKFV--ARANMHHLGEFLAGKRADCPQEAVQILDIVLRELSVKRFCPVGRSFFS-PDIKTPQ 299

  Fly   569 ELDDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDY 628
            .|.:|.|:..|.||:.    ||     .||:|::..:|...:|:||::.:...|..::...: |.
plant   300 RLGEGLESWCGFYQSI----RPTQMGLSLNIDMASAAFIEPLPVIEFVAQLLGKDVLSKPLS-DS 359

  Fly   629 SRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFEHDGKKVTIAS---YFHSR-N 689
            .|..::..|||:.|..|...:.:   |.|||.||:..|.....|..| :..|:.|   ||... .
plant   360 DRVKIKKGLRGVKVEVTHRANVR---RKYRVAGLTTQPTRELMFPVD-ENCTMKSVIEYFQEMYG 420

  Fly   690 YPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNL 754
            :.::...|.||.||:..|:..||:|.|.|.|||...::....|:..::|........|:..|:..
plant   421 FTIQHTHLPCLQVGNQKKASYLPMEACKIVEGQRYTKRLNEKQITALLKVTCQRPRDRENDILRT 485

  Fly   755 LQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYH---SKRFTMVKNGSWRMDGMKFLEPK 816
            :|:..::.||....||:.|:.....|..|:|..|.::||   .::..:.:.|.|.|...|.:...
plant   486 VQHNAYDQDPYAKEFGMNISEKLASVEARILPAPWLKYHENGKEKDCLPQVGQWNMMNKKMINGM 550

  Fly   817 PKAHKCAVLYCDPRSGRKMNYTQ--LNDFGNLIISQGKAVN----ISLDSDVTYRPFTDDERSLD 875
            ..:....|.:  .||.:: |..:  .|:.|.:....|...|    |.:.|   .|| ...|::|.
plant   551 TVSRWACVNF--SRSVQE-NVARGFCNELGQMCEVSGMEFNPEPVIPIYS---ARP-DQVEKALK 608

  Fly   876 TIF----ADLKRSQHDLAIVIIPQFRIS-YDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNI 935
            .::    ...|..:.:|.:.|:|....| |..:|:..|.:.|:::||.....| .|.:.|.:.|:
plant   609 HVYHTSMNKTKGKELELLLAILPDNNGSLYGDLKRICETELGLISQCCLTKHV-FKISKQYLANV 672

  Fly   936 LLKINSKLNGINHKIKD--DPRLPMMKN--TMYIGADVTHPSPDQREIPSVVGVAASHD-PYGAS 995
            .||||.|:.|.|..:.|  ..|:|::.:  |:..|||||||...:...||:..|.||.| |....
plant   673 SLKINVKMGGRNTVLVDAISCRIPLVSDIPTIIFGADVTHPENGEESSPSIAAVVASQDWPEVTK 737

  Fly   996 YNMQYRLQRGALEEIEDMFSITLEHLR-------------VYKEYRNAYPDHIIYYRDGVSDGQF 1047
            |......|....|.|:|::....:.:|             .:::.....|..||:||||||:|||
plant   738 YAGLVCAQAHRQELIQDLYKTWQDPVRGTVSGGMIRDLLISFRKATGQKPLRIIFYRDGVSEGQF 802

  Fly  1048 PKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHTRFFPSG--DVTTSNKFNNVDPGTVVDRT 1108
            .::...||..|::||..:  ..:|.:..::|.||||||.|.:.  |..::::..|:.||||||..
plant   803 YQVLLYELDAIRKACASLEPNYQPPVTFIVVQKRHHTRLFANNHRDKNSTDRSGNILPGTVVDTK 867

  Fly  1109 IVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAY 1173
            |.||.|..|::.||..||||::|..|:|:.:..|...|.:|.||.|||:.:.||.||||...|||
plant   868 ICHPTEFDFYLCSHAGIQGTSRPAHYHVLWDENNFTADGIQSLTNNLCYTYARCTRSVSIVPPAY 932

  Fly  1174 LAHLVAARGRVYLTGTNRFLDLKKEYAKRTIVPEFMKKN 1212
            .|||.|.|.|.||.                  ||.|:.|
plant   933 YAHLAAFRARFYLE------------------PEIMQDN 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	245/826 (30%)
		ArgoN	411..543	CDD:293095	38/144 (26%)
		ArgoL1	554..601	CDD:285861	18/51 (35%)
		PAZ	605..719	CDD:239207	34/117 (29%)
		Piwi_ago-like	764..1186	CDD:240015	145/457 (32%)
AGO10	NP_001190464.1	PLN03202	131..988	CDD:215631	255/873 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930