DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and AT5G21030

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_001331316.1	Gene:	AT5G21030 / 832227	AraportID:	AT5G21030	Length:	854	Species:	Arabidopsis thaliana

Alignment Length:	915	Identity:	230/915 - (25%)
Similarity:	366/915 - (40%)	Gaps:	206/915 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 PPQQQQAAPLPLPPQPAGSIKRGTIGKPGQ---VGINYLDLDLSKMPS-VAYHYDVKI-----MP 444
            |||..:..||..........:||. |..||   :..|:..::..|..| ..:||.|.|     .|
plant     7 PPQHMEREPLKSKSSLLPMTRRGN-GSKGQKILLLTNHFRVNFRKPNSHNFFHYSVTITYEDGSP 70

  Fly   445 ERPKKFYRQAFEQFRVDQ-----LGGAVLAYDGKASCYSVDKLPLNSQNPEVTVTDRNGRTLRYT 504
            ...|.|.|:..|  :|.|     ||....||||..:.|:|..||.:|.:..|.:.         |
plant    71 LLAKGFGRKILE--KVQQTCQADLGCKHFAYDGDKNLYTVGPLPRSSLDFSVVLE---------T 124

  Fly   505 IEIKETGDSTIDLKSLTTYMNDRIFDKP-----------------------MRAMQCVEVVLASP 546
            ...:...|..:.|...:...|..|...|                       :|.|.|  ::..:.
plant   125 APSRRNADKRLKLPHQSKKFNVAILFAPPEIPMEAIANALQGKKTKHLLDAIRVMDC--ILSQNA 187

  Fly   547 CHNKAIRVGRSFFKMSDPNNRHELDDGYEALVGLYQAFMLGDRPF-LNVDISHKSFPISMPMIEY 610
            .....:.|.:|||. :|......:.:|.:...|.:.:|....... ||:|:|........|::::
plant   188 ARQGCLLVRQSFFH-NDAKYFANIGEGVDCCKGFHSSFRTTQGGLSLNIDVSTAMIVKPGPVVDF 251

  Fly   611 L-------ERFSLK-AKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPA 667
            |       :.||:. .|..||             |:.:.|...|      :.:.|::.|||....
plant   252 LIANQGVNDPFSINWKKAKNT-------------LKNLRVKVLP------SNQEYKITGLSGLHC 297

  Fly   668 SSETF---------EHDGKKVTIASYF-HSRNYPLKFP-QLHCLNVGSSIKSILLPIELCSIEEG 721
            ..:||         |.:..::|::.|| ..|...|::. .|.|:|||...:....|||||.:...
plant   298 KDQTFTWKKRNQNREFEEVEITVSDYFTRIREIELRYSGGLPCINVGKPNRPTYFPIELCELVSL 362

  Fly   722 QALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLS 786
            |...:.....|.:|:||.:..:...|...:...|:...:|.||.:...|:||.:||..|..|||.
plant   363 QRYTKALTKFQRSNLIKESRQNPQQRIGVLTRALKTSNYNDDPMLQECGVRIGSDFTQVEGRVLP 427

  Fly   787 PPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLY---CDPRSGRKMNYTQLNDFGNLII 848
            .|:::...::.....||||......|.:|........|.:   |||:.               ||
plant   428 TPKLKAGKEQDIYPINGSWNFKNKTFFKPATVTRWAVVNFSARCDPQK---------------II 477

  Fly   849 SQ----GKAVNISLDSDVTYRPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAEL 909
            ..    ||...|::||     |:       ..:|.:            .|||:.:..:::.....
plant   478 DDLTRCGKMKGINVDS-----PY-------HVVFEE------------NPQFKDATGSVRVDKMF 518

  Fly   910 QH--GILTQCIKQFTV-----------ERKC--------------NNQTIGNILLKINSKLNGIN 947
            ||  .||.:...:|.:           |:.|              |:|.:.|:|||||:||.|:|
plant   519 QHLQSILGEVPPKFLLCILEKKNSDVYEKSCSMWNCECIVPPQNLNDQYLTNLLLKINAKLGGLN 583

  Fly   948 H----KIKDDPRLPMMKNTMYIGADVTHPSPDQRE-IPSVVGVAASHD-PYGASYNMQYRLQRGA 1006
            .    ::.....|.|...|:.||.||:|.||.|.: |||:..|.:|.: |..:.|....|.|...
plant   584 SVLDMELSGTMPLVMRVPTIIIGMDVSHGSPGQSDHIPSIAAVVSSREWPLISKYRACVRTQSPK 648

  Fly  1007 LEEIEDMF---------SITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQAC 1062
            :|.|:.:|         .|..|.|..:.......|:|||.:|||||:.||.::.|.||..:.|.
plant   649 VEMIDSLFKPVSDKDDQGIMRELLLDFHSSSGKKPNHIIIFRDGVSESQFNQVLNIELDQMMQI- 712

  Fly  1063 DKVGCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQG 1127
                            .|||:||      .:...|||.|||::|..|.|.:...|::.:|....|
plant   713 ----------------NHHTKFF------QTESPNNVLPGTIIDSNICHQHNNDFYLCAHAGKIG 755

  Fly  1128 TAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYLTGTNRF 1192
            |.:||.|:|:.:....|.|.||:|.::|.:::.|...::|..||...|||.||:    :....:|
plant   756 TTRPTHYHVLYDEIGFDTDQLQELVHSLSYVYQRSTTAISLVAPICYAHLAAAQ----MATAMKF 816

  Fly  1193 LDLKK 1197
            .|:.:
plant   817 EDMSE 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	220/874 (25%)
		ArgoN	411..543	CDD:293095	39/168 (23%)
		ArgoL1	554..601	CDD:285861	12/47 (26%)
		PAZ	605..719	CDD:239207	32/132 (24%)
		Piwi_ago-like	764..1186	CDD:240015	130/470 (28%)
AT5G21030	NP_001331316.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880