DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and AGO6

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_180853.2	Gene:	AGO6 / 817856	AraportID:	AT2G32940	Length:	878	Species:	Arabidopsis thaliana

Alignment Length:	890	Identity:	229/890 - (25%)
Similarity:	384/890 - (43%)	Gaps:	147/890 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 QQAAPLPL------PPQPAG-----SIKR--GTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMP 444
            :.::.|||      |.||:.     :.:|  ||.|.|.::..|:.::.:.:...|.|.|.|.|..
plant     2 ETSSSLPLSPISIEPEQPSHRDYDITTRRGVGTTGNPIELCTNHFNVSVRQPDVVFYQYTVSITT 66

  Fly   445 ER---------PKKFYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNS-----------QNP 489
            |.         .:|...|.|:.:..| |.|..|||||:.:.|:|..||.|.           ...
plant    67 ENGDAVDGTGISRKLMDQLFKTYSSD-LDGKRLAYDGEKTLYTVGPLPQNEFDFLVIVEGSFSKR 130

  Fly   490 EVTVTD---------RNGRTL---RYTIEIKETGDSTIDLKSLT-----TYMNDRIFDKPMRAMQ 537
            :..|:|         |:.|:.   .|.::|....:  |.||::.     .|..|:   ....|::
plant   131 DCGVSDGGSSSGTCKRSKRSFLPRSYKVQIHYAAE--IPLKTVLGTQRGAYTPDK---SAQDALR 190

  Fly   538 CVEVVLASPCHNKAIRVGRSFFKMSDPNNRHELDDGYEALVGLYQAFMLGDRP-----FLNVDIS 597
            .:::||......:...:.|..|..|| .:..::..|...:.||:.:|    ||     .||:|:|
plant   191 VLDIVLRQQAAERGCLLVRQAFFHSD-GHPMKVGGGVIGIRGLHSSF----RPTHGGLSLNIDVS 250

  Fly   598 HKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGL 662
            ........|:||:|:   ....:.....:|:.:  ....|:.:.|..|      .....:::.||
plant   251 TTMILEPGPVIEFLK---ANQSVETPRQIDWIK--AAKMLKHMRVKAT------HRNMEFKIIGL 304

  Fly   663 SRAPASSETFE---HDG------KKVTIASYFHSRNY--PLKFPQLHCLNVGSSIKSILLPIELC 716
            |..|.:.:.|.   .||      :::|:..|| .:.|  |:......||:||...:...||:|.|
plant   305 SSKPCNQQLFSMKIKDGEREVPIREITVYDYF-KQTYTEPISSAYFPCLDVGKPDRPNYLPLEFC 368

  Fly   717 SIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVS 781
            ::...|...:.....|...:::.:......|.:.:.:.:..:.::.||.::..||.|..:...|.
plant   369 NLVSLQRYTKPLSGRQRVLLVESSRQKPLERIKTLNDAMHTYCYDKDPFLAGCGISIEKEMTQVE 433

  Fly   782 TRVLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNL 846
            .|||.||.:::.........||.|..:....|||:      |:     :|...:|::...|..::
plant   434 GRVLKPPMLKFGKNEDFQPCNGRWNFNNKMLLEPR------AI-----KSWAIVNFSFPCDSSHI 487

  Fly   847 ---IISQGKAVNISLD-------SDVTYRPFTDDERSLDTIFADLKRSQHD---LAIVIIPQFRI 898
               :||.|....|.:|       .|..|:.....|| ::.:.|.:|....|   ..:.|:|:.:.
plant   488 SRELISCGMRKGIEIDRPFALVEEDPQYKKAGPVER-VEKMIATMKLKFPDPPHFILCILPERKT 551

  Fly   899 S--YDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLKINSKLNGINH--KIKDDPRLPMM 959
            |  |...|:....:.||.||||...    |.::|.:.|:||||||||.|||.  .|:....:|::
plant   552 SDIYGPWKKICLTEEGIHTQCICPI----KISDQYLTNVLLKINSKLGGINSLLGIEYSYNIPLI 612

  Fly   960 KN--TMYIGADVTHPSPDQREIPSVVGVAASHD-PYGASYNMQYRLQRGALEEIEDMFSITLEH- 1020
            ..  |:.:|.||:|..|.:.::|||..|..|.. |..:.|....|.|...||.|:.:|. .:|:
plant   613 NKIPTLILGMDVSHGPPGRADVPSVAAVVGSKCWPLISRYRAAVRTQSPRLEMIDSLFQ-PIENT 676

  Fly  1021 ------------LRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKVGCK--PKI 1071
                        :..|:..|...|..||.:|||||:.||.::...|:..|.:|..::|..  ||.
plant   677 EKGDNGIMNELFVEFYRTSRARKPKQIIIFRDGVSESQFEQVLKIEVDQIIKAYQRLGESDVPKF 741

  Fly  1072 CCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNV 1136
            ..::..|.|||:.|.:...      .||..|||||..||||....|:|.:|....||::|..|:|
plant   742 TVIVAQKNHHTKLFQAKGP------ENVPAGTVVDTKIVHPTNYDFYMCAHAGKIGTSRPAHYHV 800

  Fly  1137 IENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAAR 1181
            :.:......|.||.|.::|.::..|...:.|..||...|||.||:
plant   801 LLDEIGFSPDDLQNLIHSLSYVNQRSTTATSIVAPVRYAHLAAAQ 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	220/856 (26%)
		ArgoN	411..543	CDD:293095	39/168 (23%)
		ArgoL1	554..601	CDD:285861	14/51 (27%)
		PAZ	605..719	CDD:239207	28/124 (23%)
		Piwi_ago-like	764..1186	CDD:240015	135/453 (30%)
AGO6	NP_180853.2	PLN03202	15..878	CDD:215631	226/877 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870