DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and AGO5

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_850110.1	Gene:	AGO5 / 817334	AraportID:	AT2G27880	Length:	997	Species:	Arabidopsis thaliana

Alignment Length:	1011	Identity:	294/1011 - (29%)
Similarity:	449/1011 - (44%)	Gaps:	145/1011 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 GGHQQGRQGQEGGYQQRPPGQQQGGHEQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPS 325
            |||....:|:.||.:           ...||.|..|....|..||..|   ||.|...      :
plant     7 GGHGGASRGRGGGRR-----------SDQRQDQSSGQVAWPGLQQSYG---GRGGSVS------A 51

  Fly   326 GQQQGGHQQGRQ-GQEGGYQQRPSGQQQGGHQQGRQGQ--------------EGGYQQRPPGQQP 375
            |:.:|...:|.. |.....|...:....||..:|..|.              ....::.....:.
plant    52 GRGRGNVGRGENTGDLTATQVPVASAVSGGRGRGNIGDPTFSVASSSKTVSVASSSKEESKNTEV 116

  Fly   376 NQTQSQGQYQSRG--------PPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYL-----DLD 427
            ::|.|..|..|..        ||...:|...|:.|      .|||:||...|..|:.     |.|
plant   117 SETMSNLQITSTETKPEMTSLPPASSKAVTFPVRP------GRGTLGKKVMVRANHFLVQVADRD 175

  Fly   428 LSKMPSVAYHYDVKIMPERPKK-----FYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQ 487
            |       |||||.|.||...|     ..:...:.::...|||...||||:.|.|:...||.:|:
plant   176 L-------YHYDVSINPEVISKTVNRNVMKLLVKNYKDSHLGGKSPAYDGRKSLYTAGPLPFDSK 233

  Fly   488 NPEVTVTDR-----NGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPC 547
            ...|.:.::     :|:...:.:.:|..  ::.||..|..:::.:..:.|...:|.::|||....
plant   234 EFVVNLAEKRADGSSGKDRPFKVAVKNV--TSTDLYQLQQFLDRKQREAPYDTIQVLDVVLRDKP 296

  Fly   548 HNKAIRVGRSFFKMS----DPNNRHELDDGYEALVGLYQAFMLGDRPF-LNVDISHKSFPISMPM 607
            .|..:.||||||..|    ..:.|.||.||.|...|.:|:..|..... ||:|:|.:||...:.:
plant   297 SNDYVSVGRSFFHTSLGKDARDGRGELGDGIEYWRGYFQSLRLTQMGLSLNIDVSARSFYEPIVV 361

  Fly   608 IEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETF 672
            .:::.:| |..:..|....|..|..::..||.:.|........:||    :::|:|..|.....|
plant   362 TDFISKF-LNIRDLNRPLRDSDRLKVKKVLRTLKVKLLHWNGTKSA----KISGISSLPIRELRF 421

  Fly   673 E-HDGKKVTIASYFHSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVAN 735
            . .|..:.|:..||..: ||.:|:..|..:..||..:.:.||:|||.|:|||...::....||..
plant   422 TLEDKSEKTVVQYFAEKYNYRVKYQALPAIQTGSDTRPVYLPMELCQIDEGQRYTKRLNEKQVTA 486

  Fly   736 MIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYH-SKRFTM 799
            ::|........|:..|.||:....:| |.....||:.:......:..|||.||.::|| |.:..|
plant   487 LLKATCQRPPDRENSIKNLVVKNNYN-DDLSKEFGMSVTTQLASIEARVLPPPMLKYHDSGKEKM 550

  Fly   800 V--KNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQG-------KAVN 855
            |  :.|.|.|...|.:                 :|.|:.......|... |.:|       :.:.
plant   551 VNPRLGQWNMIDKKMV-----------------NGAKVTSWTCVSFSTR-IDRGLPQEFCKQLIG 597

  Fly   856 ISLDSDVTYRP------FTDDERSLDTIFADL-KRSQH-DLAIVIIPQFRISYDTIKQKAELQHG 912
            :.:...:.::|      .:.....::....|: ||:.. .|.|||:|....||..||:..|.:.|
plant   598 MCVSKGMEFKPQPAIPFISCPPEHIEEALLDIHKRAPGLQLLIVILPDVTGSYGKIKRICETELG 662

  Fly   913 ILTQCIKQFTVERKCNNQTIGNILLKINSKLNGINHKIKDDPR--LPMM--KNTMYIGADVTHPS 973
            |::||.:...| .|.|.|.:.|:.||||.|..|.|..:.|..|  :|::  :.|:.:|||||||.
plant   663 IVSQCCQPRQV-NKLNKQYMENVALKINVKTGGRNTVLNDAIRRNIPLITDRPTIIMGADVTHPQ 726

  Fly   974 PDQREIPSVVGVAASHD-PYGASYNMQYRLQRGALEEIEDMFSIT-------------LEHLRVY 1024
            |.:...||:..|.||.| |....|......|....|.|:|::.:.             .||...:
plant   727 PGEDSSPSIAAVVASMDWPEINKYRGLVSAQAHREEIIQDLYKLVQDPQRGLVHSGLIREHFIAF 791

  Fly  1025 KEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHTRFFPS 1087
            :......|..||:||||||:|||.::...|:..|::||:.:  ...|::..|||.||||||.||.
plant   792 RRATGQIPQRIIFYRDGVSEGQFSQVLLHEMTAIRKACNSLQENYVPRVTFVIVQKRHHTRLFPE 856

  Fly  1088 --GDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQ 1150
              |:...::|..|:.||||||..|.||||..|::.||..||||::|..|:|:.:......|.||.
plant   857 QHGNRDMTDKSGNIQPGTVVDTKICHPNEFDFYLNSHAGIQGTSRPAHYHVLLDENGFTADQLQM 921

  Fly  1151 LTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYL 1186
            ||.|||:.:.||.:|||...|||.|||.|.|.|.|:
plant   922 LTNNLCYTYARCTKSVSIVPPAYYAHLAAFRARYYM 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	254/830 (31%)
		ArgoN	411..543	CDD:293095	39/146 (27%)
		ArgoL1	554..601	CDD:285861	20/51 (39%)
		PAZ	605..719	CDD:239207	29/115 (25%)
		Piwi_ago-like	764..1186	CDD:240015	151/461 (33%)
AGO5	NP_850110.1	PLN03202	131..997	CDD:215631	264/867 (30%)
		ArgoN	150..292	CDD:293095	41/156 (26%)
		ArgoL1	303..357	CDD:285861	22/53 (42%)
		PAZ	378..485	CDD:280352	31/110 (28%)
		Piwi_ago-like	517..957	CDD:240015	151/458 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930