Protein Alignment AGO2 and AGO4

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_565633.1
• Gene: AGO4 / 817246
• AraportID: AT2G27040
• Length: 924
• Species: Arabidopsis thaliana
• Alignment Length: 901
• Identity: 223/901 - (24%)
• Similarity: 400/901 - (44%)
• Gaps: 144/901 - (15%)

  Fly   370 PPGQQPNQTQSQGQYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSV 434
            ||..:|.:.:::         ..::..|:.:|....|.   ||.|:...:..|:..:|::.:...
plant    34 PPNVEPVRVKTE---------LAEKKGPVRVPMARKGF---GTRGQKIPLLTNHFKVDVANLQGH 86

  Fly   435 AYHYDVKIMPE--RP-------KKFYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQN-- 488
            .:||.|.:..:  ||       :|...:..:.:..| |.|...||||:.:.::...||.|..:
plant    87 FFHYSVALFYDDGRPVEQKGVGRKILDKVHQTYHSD-LDGKEFAYDGEKTLFTYGALPSNKMDFS 150

  Fly   489 ---PEVTVTDRNG----------------------RTLRYTIEIKETGDSTIDLKSLTTYMNDRI 528
               .||:.|..||                      |:..:.:||...  :.|.|::|...|..:.
plant   151 VVLEEVSATRANGNGSPNGNESPSDGDRKRLRRPNRSKNFRVEISYA--AKIPLQALANAMRGQE 213

  Fly   529 FDKPMRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNNRHELDDGYEALVGLYQAFMLGDRPF-L 592
            .:....|::.::::|......:...:.|..|..:||.|...:........|.:.:|....... |
plant   214 SENSQEAIRVLDIILRQHAARQGCLLVRQSFFHNDPTNCEPVGGNILGCRGFHSSFRTTQGGMSL 278

  Fly   593 NVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVY 657
            |:|::........|::::|   .......:..::|:|:  .:..|:.:.|..:|      :.:.:
plant   279 NMDVTTTMIIKPGPVVDFL---IANQNARDPYSIDWSK--AKRTLKNLRVKVSP------SGQEF 332

  Fly   658 RVNGLSRAPASSETFE-------HDGK----KVTIASYFH-SRNYPLKF-PQLHCLNVGSSIKSI 709
            ::.|||..|...:|||       .:|:    :||:|.||. :|:..|:: ..|.|:|||...:..
plant   333 KITGLSDKPCREQTFELKKRNPNENGEFETTEVTVADYFRDTRHIDLQYSADLPCINVGKPKRPT 397

  Fly   710 LLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIA 774
            .:|:|||::...|...:.....|.:.:::.:......|...:...|:...::.:|.:...||.|:
plant   398 YIPLELCALVPLQRYTKALTTFQRSALVEKSRQKPQERMTVLSKALKVSNYDAEPLLRSCGISIS 462

  Fly   775 NDFIVVSTRVLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQ 839
            ::|..|..|||..|:::......|..:||.|..:..:|:|| .|..:..|:....|    .|..|
plant   463 SNFTQVEGRVLPAPKLKMGCGSETFPRNGRWNFNNKEFVEP-TKIQRWVVVNFSAR----CNVRQ 522

  Fly   840 LNDFGNLI-ISQGKAVNISLDSDVTYRPFTDDERS-----------LDTIFADLKRSQHDLAIVI 892
            :.|  :|| |...|.:.|:       .||...|..           ::.:|.|::..     :..
plant   523 VVD--DLIKIGGSKGIEIA-------SPFQVFEEGNQFRRAPPMIRVENMFKDIQSK-----LPG 573

  Fly   893 IPQFRIS----------YDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLKINSKLNGIN 947
            :|||.:.          |...|:|...:.||:|||:   ...|:.|:|.:.|:|||||:||.|:|
plant   574 VPQFILCVLPDKKNSDLYGPWKKKNLTEFGIVTQCM---APTRQPNDQYLTNLLLKINAKLGGLN 635

  Fly   948 H--KIKDDPRLPMMKN--TMYIGADVTHPSPDQREIPSVVGVAASHD-PYGASYNMQYRLQRGAL 1007
            .  .::..|...::..  |:.:|.||:|.||.|.::||:..|.:|.: |..:.|....|.|....
plant   636 SMLSVERTPAFTVISKVPTIILGMDVSHGSPGQSDVPSIAAVVSSREWPLISKYRASVRTQPSKA 700

  Fly  1008 EEIEDMFSIT-------LEHLRV--YKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACD 1063
            |.||.:....       ::.|.|  |.......|:|||.:|||||:.||.::.|.||..|.:||.
plant   701 EMIESLVKKNGTEDDGIIKELLVDFYTSSNKRKPEHIIIFRDGVSESQFNQVLNIELDQIIEACK 765

  Fly  1064 KVGC--KPKICCVIVVKRHHTRFF-PSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAI 1125
            .:..  .||...::..|.|||:|| |:..       .||.|||::|..|.||....|::.:|..:
plant   766 LLDANWNPKFLLLVAQKNHHTKFFQPTSP-------ENVPPGTIIDNKICHPKNNDFYLCAHAGM 823

  Fly  1126 QGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAAR 1181
            .||.:||.|:|:.:......|.||:|.::|.:::.|...::|..||...|||.||:
plant   824 IGTTRPTHYHVLYDEIGFSADELQELVHSLSYVYQRSTSAISVVAPICYAHLAAAQ 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	18/98 (18%)
		ArgoL1	554..601	CDD:462567	10/47 (21%)
		PAZ	605..719	CDD:239207	31/126 (25%)
		Piwi_ago-like	764..1186	CDD:240015	137/457 (30%)
AGO4	NP_565633.1	PLN03202	45..924	CDD:215631	220/890 (25%)