DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and Piwil4

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	XP_008764202.1	Gene:	Piwil4 / 689972	RGDID:	1311015	Length:	848	Species:	Rattus norvegicus

Alignment Length:	841	Identity:	190/841 - (22%)
Similarity:	336/841 - (39%)	Gaps:	173/841 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 KRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPERPKKFYRQAFEQFRVDQLGGAVLAYDGK 473
            |.|:.|.|.|:..|...|||.:...: |.|.|...|:...:..|.|. .:....|.....|:||
  Rat    93 KTGSSGIPVQLATNLFHLDLPQDWQL-YQYHVTYSPDLASRRLRTAL-LYNHSILSDKAKAFDG- 154

  Fly   474 ASCYSVDKLPLNSQNPEVTVTDRNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQC 538
            .|.:..:|  |:.:..|:|...:.|.|::.|:             :||:    .:|......:|.
  Rat   155 TSLFLSEK--LDHKVTELTSETQRGETVKITL-------------TLTS----ELFPNSPMCIQF 200

  Fly   539 VEVVLASPCHNKAI-RVGRSFFKMSD----PNNRHELDDGYEALVGLYQAFMLGDRPFLNVDISH 598
            ..|:........:: ::||:::|.|:    |..:..|..|:...|..:::.:|     .|.|:::
  Rat   201 FNVIFRKIFKKLSMYQIGRNYYKPSEPVEIPQYKLSLWPGFAISVSRFESKLL-----FNADVNY 260

  Fly   599 KSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLS 663
            |... :..::|::....|:..::..|...:.:      |.|: :|.|...:     :.||::.:.
  Rat   261 KVLR-NETVLEFMTDLCLRTDMSCFTETCHKQ------LVGL-IVLTRYNN-----KTYRIDDID 312

  Fly   664 RAPASSETFE-HDGKKVTIASYFHSRNY-----PLKFPQLHCL-----NVGSSIKSILLPIELCS 717
            .:...:..|: .||.:.|...|: .:.|     .|..|.|..|     |..|..:.:.|..|||.
  Rat   313 WSVKPTHAFQKRDGSETTYVDYY-KQQYDITLSDLNQPVLVSLLKRRRNDNSEPQMVHLIPELCF 376

  Fly   718 IEEGQALNRKDGATQVANMIKYAATSTNV----RKRKIMNLLQYFQHNLDPTISRF-----GIRI 773
            :     ......||....::|..|..|.:    |::::..|....|.|   .::||     |:..
  Rat   377 L-----TGLTSQATSDFRLMKAVAEETRLSPMGRQQQLARLADDIQRN---QVTRFELETWGLHF 433

  Fly   774 ANDF-----IVVSTRVLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKP----------KAHKC- 822
            .:..     :|.|.::|    ::.|:.:.....:.|..|...|.|..:|          :|...
  Rat   434 GSQLSLTGRVVPSEKIL----LQDHTCQPAFAADWSKDMRSCKVLSSEPLNTWLIVCCSRAEHLI 494

  Fly   823 -AVLYCDPRSGRKMNYTQLNDFGNLIISQG---------------KAVNISLDSDVTYRPFTDDE 871
             :.|.|..|.|           |:...|.|               :|:.:.::.||
  Rat   495 ESFLSCLRRVG-----------GSTGFSVGHPKIIKVDENPAAFLRAIQLHVNPDV--------- 539

  Fly   872 RSLDTIFADLKRSQHDLAIVIIPQFRIS-YDTIKQKAELQHGILTQCIKQFTVERKCNNQTIG-N 934
                           .|.:.|:|..:.: ||:||:.......:.:||:...|:.::....::. .
  Rat   540 ---------------QLVMCILPSNQKNYYDSIKRYLSSDCPVPSQCVLTRTLNKQGMMLSVATK 589

  Fly   935 ILLKINSKLNGINHKIKDDPRLPMMKNTMYIGADVTHP--SPDQREIPSVVGVAASHDPYGASYN 997
            |.:::..||.|....::    :| :|:.|.:|.|:...  |.|    .:|||..||.:.....:.
  Rat   590 IAMQMTCKLGGELWAVE----IP-LKSLMVVGIDICRDALSKD----VAVVGFVASINSRITRWF 645

  Fly   998 MQYRLQRGALEEIEDMFSITLE-HLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQA 1061
            .:..|||.| .:|.|...:.:. .|..:.::.:..|..||.|||||.:||...:...|:..:..:
  Rat   646 SRCVLQRTA-ADIADCLKVCMTGALNKWYKHNHDLPARIIAYRDGVGNGQLKAVLEYEVPQLLSS 709

  Fly  1062 CDKVGCKPKIC---CVIVVKRHHTRFFPSGDVTTSNKFNNVDP-GTVVDRTIVHPNEMQFFMVSH 1122
            ..:.|...:.|   .|:|.||...|.|.....|..|     .| |||||.....|....|::.|.
  Rat   710 VTECGSDARSCRLSVVVVRKRCLLRLFAESGHTLQN-----PPLGTVVDSEATRPEWYDFYLTSQ 769

  Fly  1123 QAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAH----LVA 1179
            .|.:||..||.||||.:...|..|.:|:||:.|||::......:|.|||...||    |||
  Rat   770 TANRGTVSPTYYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGVISVPAPCQYAHKLTFLVA 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	189/839 (23%)
		ArgoN	411..543	CDD:293095	31/131 (24%)
		ArgoL1	554..601	CDD:285861	12/50 (24%)
		PAZ	605..719	CDD:239207	25/124 (20%)
		Piwi_ago-like	764..1186	CDD:240015	112/466 (24%)
Piwil4	XP_008764202.1	ArgoN	95..205	CDD:293095	31/131 (24%)
		PAZ_piwi_like	265..381	CDD:239211	25/133 (19%)
		Piwi_piwi-like_Euk	389..831	CDD:240016	119/499 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910