DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and Ago2

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	XP_038936150.1	Gene:	Ago2 / 59117	RGDID:	621255	Length:	860	Species:	Rattus norvegicus

Alignment Length:	845	Identity:	273/845 - (32%)
Similarity:	422/845 - (49%)	Gaps:	70/845 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 YQSRGPPQQQQA---APLP-----LPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDV 440
            |...||.....|   :|:|     .||:|    ..||.|:..::..|:.::|:.|:.  .|||::
  Rat     2 YSGAGPVLASPAPTTSPIPGYAFKPPPRP----DFGTTGRTIKLQANFFEMDIPKID--IYHYEL 60

  Fly   441 KIMPER-PKKFYRQAFE----QFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVT-DRNGR 499
            .|.||: |::..|:..|    .|:....|.....:||:.:.|:...||:.....|:.|| ...|:
  Rat    61 DIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGK 125

  Fly   500 TLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIR---VGRSFFKM 561
            ...:.:.||..  |.:.|::|...::.|:...|...:|.::||:.   |..::|   ||||||..
  Rat   126 DRIFKVSIKWV--SCVSLQALHDALSGRLPSVPFETIQALDVVMR---HLPSMRYTPVGRSFFTA 185

  Fly   562 SDPNNRHELDDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYL-ERFSLKAKI 620
            |: ...:.|..|.|...|.:|:.    ||     .||:|:|..:|..:.|:||:: |....|:..
  Rat   186 SE-GCSNPLGGGREVWFGFHQSV----RPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIE 245

  Fly   621 NNTTNLDYSRR--FLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETF---EHDGKKV- 679
            .....|..|:|  |.:. ::|:.|..|.....:   |.|||..::|.|||.:||   :..|:.|
  Rat   246 EQQKPLTDSQRVKFTKE-IKGLKVEITHCGQMK---RKYRVCNVTRRPASHQTFPLQQESGQTVE 306

  Fly   680 -TIASYFHSRN-YPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAAT 742
             |:|.||..|: ..|::|.|.||.||...|...||:|:|:|..||...:|....|.:.||:..|.
  Rat   307 CTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATAR 371

  Fly   743 STNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEY--HSKRFTMVKNGSW 805
            |...|:.:|..|::....|.||.:..|||.:.::...|:.|||.||.:.|  .:|.......|.|
  Rat   372 SAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVW 436

  Fly   806 RMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPF 867
            .|...:|   :|.|..|..|..    |:  |:.....|..|...:....:...:.:.....:..:
  Rat   437 DMRNKQFHTGIEIKVWAIACFA----PQ--RQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKY 495

  Fly   868 TDDERSLDTIFADLKRSQH--DLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQ 930
            .....|::.:|..||.:..  .|.:||:|.....|..:|:..:...|:.|||::...|:| ...|
  Rat   496 AQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQR-TTPQ 559

  Fly   931 TIGNILLKINSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPYGA 994
            |:.|:.||||.||.|:|:.:....|.|:.:. .:::|||||||.....:.||:..|..|.|.:..
  Rat   560 TLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPN 624

  Fly   995 SYNMQYRLQRGALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCI 1058
            .|....|:|:...|.|:|:.::..|.| :.||..| ..|..||:||||||:|||.::.:.||..|
  Rat   625 RYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTR-FKPTRIIFYRDGVSEGQFQQVLHHELLAI 688

  Fly  1059 KQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVS 1121
            ::||.|:  ..:|.|..::|.||||||.|.:.......|..|:..||.||..|.||.|..|::.|
  Rat   689 REACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCS 753

  Fly  1122 HQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYL 1186
            |..||||::|:.|:|:.:......|.||.|||.|||.:.||.||||.|||||.|||||.|.|.:|
  Rat   754 HAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHL 818

Fly 1187 1186
Rat 819 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	260/802 (32%)
		ArgoN	411..543	CDD:293095	35/137 (26%)
		ArgoL1	554..601	CDD:285861	18/51 (35%)
		PAZ	605..719	CDD:239207	41/122 (34%)
		Piwi_ago-like	764..1186	CDD:240015	151/432 (35%)
Ago2	XP_038936150.1	PLN03202	7..859	CDD:215631	271/840 (32%)
Ago2	XP_038936150.1	Piwi_ago-like	393..818	CDD:240015	151/432 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030