Protein Alignment AGO2 and piwil2

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_001352553.2
• Gene: piwil2 / 572134
• ZFINID: ZDB-GENE-060526-345
• Length: 1046
• Species: Danio rerio
• Alignment Length: 1180
• Identity: 263/1180 - (22%)
• Similarity: 426/1180 - (36%)
• Gaps: 315/1180 - (26%)

  Fly   163 PPGQQQGGHQQGRQGQEGGYQQRPSGQQQG-------------------GHQQGRQGQEGGYQQR 208
            |||..:...||..:.|.....|...|:.:|                   |....|.|:  |..|.
Zfish    11 PPGVIRAPWQQSTEDQSQLLDQPSLGRARGLIMPIDEPLPGRGRAFSVLGEMPVRFGR--GITQS 73

  Fly   209 PPGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQQGGHQQGRQG---- 269
            ...:...|..:|        .:.|  .::||..:||     |:....|....|..:....|
Zfish    74 IAAEPLVGMARG--------VRLP--MEEGGFGRGR-----GFLLPTPEPTVGIGRGAAIGPVPT 123

  Fly   270 ---QEGGYQQRPPG-QQQGGHEQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPSGQQQG 330
               |:...:::.|. |.:......:.|..|......|..:..|.:.|:....|.   .|.|
Zfish   124 LDIQKAEVEEKMPELQAEVAPTVAKVGSPGTGSSLVSMFRGLGIEPGKTWGRGA---APVG---- 181

  Fly   331 GHQQGRQGQEGG-YQQRPS--GQQQGGHQQGRQGQEG------GYQQRPPGQQPNQTQSQGQYQS 386
               :|..|..|. .|.:|:  |......::..:.:|.      |:........|:.|..:|..
Zfish   182 ---RGAAGDMGADLQPKPTIIGASLTPEREEVRSEESISFLGRGFTGFGRAAMPHMTVGRGPI-- 241

  Fly   387 RGP--PQQQQAAPLPL----------------PPQPAGSI--------KRGTIGKPGQVGINYLD 425
             ||  |....|||..|                ||:....|        |.||.|.|..:|.||:.
Zfish   242 -GPLSPSPSVAAPFSLISASSSSEDAPVAPGTPPKVEVKIETVKEPLQKIGTKGSPIPIGSNYIP 305

  Fly   426 LDLSKMPSVAYHYDVKIMPERPKKFYRQAFEQFRVDQLG-------------GAVLAYDGKASCY 477
            :....  ...:.|.|...|              .|:.|.             |.|:|:||
Zfish   306 ICCKN--DAVFQYHVTFTP--------------NVESLSMRFGMMKEHRPTTGEVVAFDG----- 349

  Fly   478 SVDKLPLNSQNPEVTVTDRNGRTLRYTIEIK---ETGDSTIDLK-SLTTYMNDRIFDKPMRAMQC 538
            |:..||               :.|...:.:|   :|.:..||:| .||..:       |..:..|
Zfish   350 SILYLP---------------KRLEEVVHLKAERKTDNQEIDIKIQLTKIL-------PPSSDLC 392

  Fly   539 VEVVLASPCHNKAIR----------VGRSFFKMSDPN-----NRHELD--DGYEALV-----GLY 581
            :      |.:|..:|          |||:.:   |||     .:|.|.  .||...:     |||
Zfish   393 I------PFYNVVLRRVMKILGLKLVGRNHY---DPNAVVILGKHRLQVWPGYSTSIKHTDGGLY 448

  Fly   582 QAFMLGDRPFLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYT- 645
                      |.||:|||                   .:.|.:.||.           :|::|.
Zfish   449 ----------LVVDVSHK-------------------VLRNDSVLDV-----------MNLIYQG 473

  Fly   646 PPQSFQSA---------------PRVYRVNGLSRAPASSETFE-HDGKKVTIASYFHSRNYPLKF 694
            ..:|||..               .|.||::.:..:.:..:||. .||...|...|:. :||.:..
Zfish   474 SRESFQDECTKEFVGSIVITRYNNRTYRIDDIEWSKSPKDTFTLADGSVTTFVDYYR-KNYGITI 537

  Fly   695 PQL----------HCLNVGSSI---KSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNV 746
            .:|          .....|..:   :.:||| ||..:.......|||     ...:|......||
Zfish   538 KELDQPLLIHRPKERSRPGGKVITGEILLLP-ELSFMTGIPEKMRKD-----FRAMKDLTMHINV 596

  Fly   747 RKRKIMNLLQYFQHNLDPT------ISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMVKNGSW 805
            ..::....|:...||::..      :.|:|:.|:.:.:|...|.|....:..||..|.......|
Zfish   597 GAQQHTQSLKQLLHNINSNNEALSELGRWGLSISQEILVTQGRTLPSETICLHSASFVTSPAVDW 661

  Fly   806 RMDGMKFLEPKPKAHKC-AVLYCDPRSGRKMNYTQLNDFGNLIISQG----KAVNISLDSDVT-- 863
            ..:.::..........| ||.|  ||.........:..|..:....|    :.:.:.|..|.|
Zfish   662 SRELVRDPSISTVPLNCWAVFY--PRRATDQAEELVTTFSRVAGPMGMRVERPIRVELRDDRTET 724

  Fly   864 -----YRPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTV 923
                 :...|.:.| :..:...:..::.||           |..||:...:|..:.:|.|...|:
Zfish   725 FVKSIHSQLTSEPR-VQLVVCIMTGNRDDL-----------YSAIKKLCCIQSPVPSQAINVRTI 777

  Fly   924 ERKCNNQTIG-NILLKINSKLNG----INHKIKDDPRLPMMKNTMYIGADVTHPSPDQREIPSVV 983
            .:....:::. .|||:||.||.|    :|        :| :|..|.||.||.|.:  .::..||:
Zfish   778 SQPQKLRSVAQKILLQINCKLGGELWTVN--------VP-LKYLMVIGVDVHHDT--SKKSRSVM 831

  Fly   984 GVAASHDPYGASYNMQYRLQRGALEEIEDMFSI-TLEHLRVYKEYRNAYPDHIIYYRDGVSDGQF 1047
            |..||.:.....:..:...|. ..|||.:.|.: .|..|:.|.|..:|:|:.|:.|||||||||.
Zfish   832 GFVASLNSMLTKWYSRVTFQM-PNEEIINGFRVCLLAALQKYYEVNHAFPEKIVIYRDGVSDGQL 895

  Fly  1048 PKIKNEELRCIKQACDKV-GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVH 1111
            ..:::.|:..|.:..:.: ..:||:..::|.||..|..:..|    |:.|....||||:|.|:.:
Zfish   896 KTVEHYEIPQILKCFETIPNYEPKLAFIVVQKRISTTLYSYG----SDHFGTPSPGTVLDHTVTN 956

  Fly  1112 PNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAH 1176
            .:.:.|::::|...||...||.|..:.||.||..|.||:||:.:||::.....::..|||...||
Zfish   957 RDWVDFYLMAHSIRQGCGLPTHYITVYNTANLTPDHLQRLTFKMCHLYWNWPGTIRVPAPCKYAH 1021

  Fly  1177 LVAARGRVYL 1186
            .:|.....||
Zfish  1022 KLAFLSGQYL 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	15/75 (20%)
		ArgoL1	554..601	CDD:462567	19/58 (33%)
		PAZ	605..719	CDD:239207	26/143 (18%)
		Piwi_ago-like	764..1186	CDD:240015	116/446 (26%)
piwil2	NP_001352553.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		7/23 (30%)