DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AGO2 and ago1

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	XP_005158529.2	Gene:	ago1 / 570775	ZFINID:	ZDB-GENE-110606-3	Length:	871	Species:	Danio rerio

Alignment Length:	864	Identity:	283/864 - (32%)
Similarity:	421/864 - (48%)	Gaps:	86/864 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 PPGQQPNQTQSQGQYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSV 434
            |.|..|     .|.|    ||..||....|..|      ..||:|||.::..||.::::.||.
Zfish     5 PSGAVP-----VGPY----PPPLQQVFQAPRRP------GMGTVGKPIKLLANYFEVEIPKMD-- 52

  Fly   435 AYHYDVKIMPER-PKKFYRQAFE----QFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVT 494
            .:||:|.|.|:: |::..|:..|    .|:....|.....||||.:.|:|..||:.|:..:..||
Zfish    53 VFHYEVDIKPDKCPRRVNREVVEYMVQHFKPQLFGDRKPVYDGKKNIYTVLALPIGSEKVDFEVT 117

  Fly   495 -DRNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIRVGRSF 558
             ...|:...:.:.|:.....:..|.. .|.::.|: ..|:.::|.::|.:......:...|||||
Zfish   118 IPGEGKDRIFKVSIRWLAKVSWRLLQ-ETLVSGRL-QVPLESVQALDVAMRHLASMRYTPVGRSF 180

  Fly   559 FKMSDPNN-RHELDDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYLERFSLK 617
            |  |.|.. .|.|..|.|...|.:|:.    ||     .||:|:|..:|..:.|:||::
Zfish   181 F--SPPEGYYHPLGGGREVWFGFHQSV----RPAMWKMMLNIDVSATAFYKAQPVIEFM------ 233

  Fly   618 AKINNTTNLDYSRRFLEPF--------LRGINVVYTPPQSF----------QSAPRVYRVNGLSR 664
            .::.:..|:|...:.|...        ::||...::|..||          ....|.|||..::|
Zfish   234 CEVLDIRNIDEQPKTLTDSQRVRFTKEIKGILQKHSPGVSFVGLKVEVTHCGQMKRKYRVCNVTR 298

  Fly   665 APASSETFE---HDGKKV--TIASYFHSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQA 723
            .|||.:||.   ..|:.|  |:|.||..: |..||:|.|.||.||...|...||:|:|:|..||.
Zfish   299 RPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQR 363

  Fly   724 LNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPP 788
            ..:|....|.:.|||..|.|...|:.:|..|::....||||.|..|||::.:|...|:.|||..|
Zfish   364 CIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNANFNLDPYIQEFGIKVKDDMTEVTGRVLPAP 428

  Fly   789 QVEY--HSKRFTMVKNGSWRMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLII 848
            .::|  .::.......|.|.|.|.:|   :|.|..|..|..    |:  ::.....|.:|.:.:.
Zfish   429 ILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFA----PQ--KQCREEVLKNFTDQLR 487

  Fly   849 SQGKAVNISLDSDVTYRPFTDDERSLDTIFADLKR--SQHDLAIVIIPQFRISYDTIKQKAELQH 911
            ...|...:.:.....:..:.....|::.:|..||.  |...|.|||:|.....|..:|:..:...
Zfish   488 KISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLL 552

  Fly   912 GILTQCIKQFTVERKCNNQTIGNILLKINSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPD 975
            |:.|||::...|. |.:.||:.|:.||||.||.|||:.:....|..:.:. .:::|||||||...
Zfish   553 GMATQCVQVKNVV-KTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAG 616

  Fly   976 QREIPSVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYR 1039
            ..:.||:..|..|.|.:.:.|....|:||...|.|||:..:..|.| :.||..| ..|..||:||
Zfish   617 DGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTR-FKPTRIIFYR 680

  Fly  1040 DGVSDGQFPKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPG 1102
            |||.:||.|:|.:.||..|:.||.|:  ..:|.|..::|.||||||.|.:.......|..|:..|
Zfish   681 DGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKSERIGKSGNIPAG 745

  Fly  1103 TVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVS 1167
            |.||.:|.||.|..|::.||..||||::|:.|.|:.:......|.||.|||.|||.:.||.||||
Zfish   746 TTVDTSITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVS 810

  Fly  1168 YPAPAYLAHLVAARGRVYL 1186
            .|||||.|.|||.|.|.:|
Zfish   811 IPAPAYYARLVAFRARYHL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	268/815 (33%)
		ArgoN	411..543	CDD:293095	38/137 (28%)
		ArgoL1	554..601	CDD:285861	20/52 (38%)
		PAZ	605..719	CDD:239207	41/137 (30%)
		Piwi_ago-like	764..1186	CDD:240015	155/432 (36%)
ago1	XP_005158529.2	PLN03202	1..870	CDD:215631	283/864 (33%)
		ArgoN	27..165	CDD:293095	39/147 (27%)
		ArgoL1	176..225	CDD:285861	21/54 (39%)
		PAZ_argonaute_like	226..359	CDD:239212	41/138 (30%)
		Piwi_ago-like	404..829	CDD:240015	155/432 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.930