Protein Alignment AGO2 and ago2

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_009292643.1
• Gene: ago2 / 570630
• ZFINID: ZDB-GENE-110606-6
• Length: 898
• Species: Danio rerio
• Alignment Length: 911
• Identity: 275/911 - (30%)
• Similarity: 430/911 - (47%)
• Gaps: 118/911 - (12%)

  Fly   335 GRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQPNQTQSQGQYQSRGPPQQQQAAPLP 399
            |..|....:|.|||           .|.:......||..|        :|..: |||:...
Zfish     5 GAAGATELFQGRPS-----------SGSDVSAPASPPAPQ--------EYVFK-PPQRPDF---- 45

  Fly   400 LPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPER-PKKFYRQAFE----QFR 459
                       ||:|:..::..|:.::::.|:.  .|||::.|.||: |::..|:..|    .|:
Zfish    46 -----------GTMGRTIKLQANFFEMEIPKLE--VYHYEIDIKPEKCPRRVNREIVEHMVQHFK 97

  Fly   460 VDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVT-DRNGRTLRYTIEIKETGDSTIDLKSLTTY 523
            ....|.....|||:.:.|:...||:.....|:.|| ...|:...:.:.||..  |.:.|::|...
Zfish    98 TQIFGDRKPVYDGRKNLYTAMPLPIGRDKVELEVTIPGEGKDRSFKVAIKWM--SCVSLQALHEA 160

  Fly   524 MNDRIFDKPMRAMQCVEVVLASPCHNKAIR---VGRSFFKMSDPNNRHELDDGYEALVGLYQAFM 585
            ::.|:.:.|...:|.::||:.   |..::|   ||||||..|: ...:.|..|.|...|.:|:.
Zfish   161 LSGRLPNIPFETIQALDVVMR---HLPSMRYTPVGRSFFTPSE-GCSNPLGGGREVWFGFHQSV- 220

  Fly   586 LGDRP-----FLNVDISHKSFPISMPMIEYL-ERFSLKAKINNTTNLDYSRR--FLEPFLRGINV 642
               ||     .||:|:|..:|..:.|:||:: |....|:.......|..|:|  |.:. ::|:.|
Zfish   221 ---RPSLWKMMLNIDVSATAFYKAQPVIEFMCEVLDFKSIEEQQKPLTDSQRVKFTKE-IKGLKV 281

  Fly   643 VYTPPQSFQSAPRVYRVNGLSRAPASSETF---EHDGKKV--TIASYFHSR-NYPLKFPQLHCLN 701
            ..|.....:   |.|||..::|.|||.:||   :.:|:.:  |:|.||..: ...|::|.|.||.
Zfish   282 EITHCGQMK---RKYRVCNVTRRPASHQTFPLQQENGQTIECTVAQYFKDKYKLVLRYPHLPCLQ 343

  Fly   702 VGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTI 766
            ||...|...||:|:|:|..||...:|....|.:.||:..|.|...|:.:|..|::....|.||.:
Zfish   344 VGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQDEISKLMRSANFNTDPYV 408

  Fly   767 SRFGIRIANDFIVVSTRVLSPPQVEY---------------------------HSKRFTMVKNGS 804
            ..||:.:.:|...|:.|||..|.:.|                           .:|.......|.
Zfish   409 REFGVMVRDDMTEVNGRVLQAPSILYGGRVRISSAQLSIWLNPCLIWSCLWLFQNKAIATPVQGV 473

  Fly   805 WRMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRP 866
            |.|...:|   :|.|..|..|..    |:  |:.....|..|.:.:....:...:.:.....:..
Zfish   474 WDMRNKQFHTGIEIKVWAIACFA----PQ--RQCTELLLKAFTDQLRKISRDAGMPIQGQPCFCK 532

  Fly   867 FTDDERSLDTIFADLKRSQH--DLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNN 929
            :.....|::.:|..||.:..  .|.:||:|.....|..:|:..:...|:.|||::...|: |...
Zfish   533 YAQGADSVEPMFKHLKYTYQGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQVKNVQ-KTTP 596

  Fly   930 QTIGNILLKINSKLNGINHKIKDDPR-LPMMKNTMYIGADVTHPSPDQREIPSVVGVAASHDPYG 993
            ||:.|:.||||.||.|:|:.:....| |...:..:::|||||||.....:.||:..|..|.|.:.
Zfish   597 QTLSNLCLKINVKLGGVNNILLPQGRPLVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHP 661

  Fly   994 ASYNMQYRLQRGALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRC 1057
            :.|....|:|:...:.|:|:.::..|.| :.||..| ..|..|||||||:|:|||.::...||..
Zfish   662 SRYCATVRVQQHRQDIIQDLATMVRELLIQFYKSTR-FKPTRIIYYRDGISEGQFNQVLQHELLA 725

  Fly  1058 IKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMV 1120
            |::||.|:  ..:|.|..|:|.||||||.|.........|..|:..||.||..|.||.|..|::.
Zfish   726 IREACIKLEKDYQPGITFVVVQKRHHTRLFCMDRNERVGKSGNIPAGTTVDTKITHPFEFDFYLC 790

  Fly  1121 SHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVY 1185
            ||..||||::|:.|:|:.:..:...|.||.|||.|||.:.||.||||.|||||.|||||.|.|.:
Zfish   791 SHAGIQGTSRPSHYHVLWDDNHFTSDELQVLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYH 855

  Fly  1186 L 1186
            |
Zfish   856 L 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	18/72 (25%)
		ArgoL1	554..601	CDD:462567	18/51 (35%)
		PAZ	605..719	CDD:239207	39/122 (32%)
		Piwi_ago-like	764..1186	CDD:240015	150/457 (33%)
ago2	XP_009292643.1	ArgoN	106..180	CDD:465134	19/75 (25%)
		ArgoL1	190..240	CDD:462567	19/54 (35%)
		PAZ_argonaute_like	241..361	CDD:239212	39/123 (32%)
		Piwi_ago-like	406..856	CDD:240015	150/457 (33%)