Protein Alignment AGO2 and ago3a

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_068070095.1
• Gene: ago3a / 567622
• ZFINID: ZDB-GENE-051107-16
• Length: 876
• Species: Danio rerio
• Alignment Length: 848
• Identity: 268/848 - (31%)
• Similarity: 410/848 - (48%)
• Gaps: 91/848 - (10%)

  Fly   400 LPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPER-PKKFYRQA----FEQFR 459
            :|.:|.    .||:|||.::..|...:::.||.  .|.|:|.|.||: |::..|:.    .:.|:
Zfish    17 MPRRPG----YGTMGKPIKLLANCFQVEIPKMD--VYLYEVDIKPEKCPRRVNREVVDSMVQHFK 75

  Fly   460 VDQLGGAVLAYDGKASCYSVDKLPL--NSQNPEVTVTDRNGRTLRYTIEIKETGDSTIDLKSLTT 522
            |...|.....||||.|.|:.:.||:  ...:.:||:....|:...:.:.||..  |.:....|..
Zfish    76 VTIFGDRRPVYDGKKSLYTANPLPVAPAGVDLDVTLPGEGGKDRPFKVSIKFV--SLVSWHLLHE 138

  Fly   523 YMNDRI------FDKPM--RAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNNRHELDDGYEALVG 579
            .:..|.      .|||:  ..:..|:|||......|...||||||...:..: |.|..|.|...|
Zfish   139 VLTGRSMPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYD-HPLGGGREVWFG 202

  Fly   580 LYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPF--- 636
            .:|:.    ||     .||:|:|..:|..:.|:|:::      .::.:..|:|...|.|...
Zfish   203 FHQSV----RPAMWKMMLNIDVSATAFYKAQPVIQFM------CEVLDIHNIDEQPRPLTDSHRV 257

  Fly   637 -----LRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGKKV--TIASYFHSR-NY 690
                 ::|:.|..|...:.:   |.|||..::|.|||.:||.   .:|:.|  |:|.||..: |.
Zfish   258 KFTKEIKGLKVEVTHCGTMR---RKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYNL 319

  Fly   691 PLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLL 755
            .||:|.|.||.||...|...||:|:|:|..||...:|....|.:.|||..|.|...|:.:|..|:
Zfish   320 QLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLV 384

  Fly   756 QYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEY----HSKRFTMV--------------KN 802
            :...:..||.:..|..::.::...|:.|||..|.::|    .::.|..:              .:
Zfish   385 RSANYEADPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRVSTEHFMQINRELSFQNRTVATPSH 449

  Fly   803 GSWRMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTY 864
            |.|.|.|.:|   :|.|..|..|..      :.|:.....|..|.:.:....|...:.:.....:
Zfish   450 GVWDMRGKQFHTGVEIKMWAIACFA------TQRQCREEILKGFTDQLRKISKDAGMPIQGQPCF 508

  Fly   865 RPFTDDERSLDTIFADLKR--SQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKC 927
            ..:.....|::.:|..||.  |...|.|||:|.....|..:|:..:...|:.|||::...|. |.
Zfish   509 CKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVV-KT 572

  Fly   928 NNQTIGNILLKINSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDP 991
            :.||:.|:.||||.||.|||:.:....|..:.:. .:::|||||||.....:.||:..|..|.|.
Zfish   573 SPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDA 637

  Fly   992 YGASYNMQYRLQRGALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEEL 1055
            :.:.|....|:||...|.|:|:.|:..|.| :.||..|.. |..||:||||||:|||.::...||
Zfish   638 HPSRYCATVRVQRPRQEVIQDLSSMVRELLIQFYKSTRYK-PTRIIFYRDGVSEGQFRQVLYYEL 701

  Fly  1056 RCIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFF 1118
            ..|::||..:  ..:|.|..::|.||||||.|.:.......:..|:..||.||..|.||.|..|:
Zfish   702 LAIREACISLEKEYQPGITYIVVQKRHHTRLFCADRNERVGRSGNIPAGTTVDTDITHPYEFDFY 766

  Fly  1119 MVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGR 1183
            :.||..||||::|:.|:|:.:......|..|.|||.|||.:.||.||||.|||||.|||||.|.|
Zfish   767 LCSHAGIQGTSRPSHYHVLWDDNCFTADEFQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRAR 831

  Fly  1184 VYL 1186
            .:|
Zfish   832 YHL 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	20/81 (25%)
		ArgoL1	554..601	CDD:462567	18/51 (35%)
		PAZ	605..719	CDD:239207	39/127 (31%)
		Piwi_ago-like	764..1186	CDD:240015	150/448 (33%)
ago3a	XP_068070095.1	ArgoN	73..167	CDD:465134	24/95 (25%)
		ArgoL1	177..227	CDD:462567	19/54 (35%)
		PAZ_argonaute_like	228..348	CDD:239212	39/128 (30%)
		Piwi_ago-like	393..834	CDD:240015	150/448 (33%)