DRSC/TRiP Functional Genomics Resources

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Protein Alignment AGO2 and PIWIL2

DIOPT Version :10

Sequence 1:NP_730054.1 Gene:AGO2 / 39683 FlyBaseID:FBgn0087035 Length:1217 Species:Drosophila melanogaster
Sequence 2:NP_060538.2 Gene:PIWIL2 / 55124 HGNCID:17644 Length:973 Species:Homo sapiens


Alignment Length:889 Identity:223/889 - (25%)
Similarity:354/889 - (39%) Gaps:197/889 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   386 SRGPPQQQQAAPLPLPPQPAGS-----------------IKRGTIGKPGQVGINYLDLDLSKMPS 433
            |||||  |.::|..||..|..|                 :|:|:.|.|..:|:|.:.:....  .
Human   178 SRGPP--QLSSPPALPQSPLHSPDRPLVLTVEHKEKELIVKQGSKGTPQSLGLNLVKIQCHN--E 238

  Fly   434 VAYHYDVKIMPERPKKFYRQAFEQFRVDQ-LGGAVLAYDGKASCYSVDKLPLNSQNPEVTVTDRN 497
            ..|.|.|...|....|..|  |...:..| :.|.|.|:||     |:..||:.            
Human   239 AVYQYHVTFSPNVECKSMR--FGMLKDHQAVTGNVTAFDG-----SILYLPVK------------ 284

  Fly   498 GRTLRYTIEIK---ETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIR------ 553
               |:..:|:|   :|..:.|.:|...|.:.:...|            |..|.:|...|      
Human   285 ---LQQVLELKSQRKTDSAEISIKIQMTKILEPCSD------------LCIPFYNVVFRRVMKLL 334

  Fly   554 ----VGRSFFKMSDPNN-----RHELD--DGYEALV-----GLYQAFMLGDRPFLNVDISHKSFP 602
                |||:|:   ||.:     :|.|.  .||.|.:     ||          ||..|:|||   
Human   335 DMKLVGRNFY---DPTSAMVLQQHRLQIWPGYAASIRRTDGGL----------FLLADVSHK--- 383

  Fly   603 ISMPMIEYLERFSLKAKINNTTNLDYSRRFLE-----------PFLRGINVVYTPPQSFQSAPRV 656
                            .|.|...||......:           ..|.| |:|.|...:     |.
Human   384 ----------------VIRNDCVLDVMHAIYQQNKEHFQDECTKLLVG-NIVITRYNN-----RT 426

  Fly   657 YRVNGL--SRAPASSETFEHDGKKVTIASYFHSRNY---------PLKF--PQLHCLNVGSSIKS 708
            ||::.:  ::.|..|.|.. |||::|...|: |:||         ||..  |.....|.|..:|.
Human   427 YRIDDVDWNKTPKDSFTMS-DGKEITFLEYY-SKNYGITVKEEDQPLLIHRPSERQDNHGMLLKG 489

  Fly   709 ILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPT--ISRFGI 771
            .:|.:...|...|.....|.....:.::.:....|.......:..|||....|...|  :.|:|:
Human   490 EILLLPELSFMTGIPEKMKKDFRAMKDLAQQINLSPKQHHSALECLLQRIAKNEAATNELMRWGL 554

  Fly   772 RIANDFIVVSTRVLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPK-----AHKCAVLYCDPRS 831
            |:..|...:..|||...::...:..|...:..:|    :|.:...|.     .|..|:.|  |: 
Human   555 RLQKDVHKIEGRVLPMERINLKNTSFITSQELNW----VKEVTRDPSILTIPMHFWALFY--PK- 612

  Fly   832 GRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDE-----RSLDTIFADLKRSQHDLAIV 891
             |.|:  |..:..|::......:.:.: |...:....||.     |::.:......:.|..:.|:
Human   613 -RAMD--QARELVNMLEKIAGPIGMRM-SPPAWVELKDDRIETYVRTIQSTLGAEGKIQMVVCII 673

  Fly   892 IIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQTIG-NILLKINSKLNGINHKIKDDPR 955
            :.|:..: |..||:...:|..:.:|.:...|:.:....:::. .|||:||.||.|....: |.| 
Human   674 MGPRDDL-YGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQINCKLGGELWGV-DIP- 735

  Fly   956 LPMMKNTMYIGADVTH-PSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLE 1019
               :|..|.||.||.| ||   |.:.||||..||.:.....:..:...|....|.::.:....:.
Human   736 ---LKQLMVIGMDVYHDPS---RGMRSVVGFVASINLTLTKWYSRVVFQMPHQEIVDSLKLCLVG 794

  Fly  1020 HLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHT 1082
            .|:.:.|..:..|:.|:.|||||||||...:.|.|:..: |.|.:.  ..:||:...:|.|:..|
Human   795 SLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQL-QKCFEAFENYQPKMVVFVVQKKIST 858

  Fly  1083 RFF---PSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLD 1144
            ..:   |...||.:       ||||||.||.....:.|::::|...||...||.|..:.||.||.
Human   859 NLYLAAPQNFVTPT-------PGTVVDHTITSCEWVDFYLLAHHVRQGCGIPTHYVCVLNTANLS 916

  Fly  1145 IDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYLTG 1188
            .|.:|:||:.||||:.....::..|||...||.:|     :|:|
Human   917 PDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLA-----FLSG 955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AGO2NP_730054.1 ArgoN 471..543 CDD:465134 13/74 (18%)
ArgoL1 554..601 CDD:462567 19/58 (33%)
PAZ 605..719 CDD:239207 31/137 (23%)
Piwi_ago-like 764..1186 CDD:240015 119/440 (27%)
PIWIL2NP_060538.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..199 11/22 (50%)
ArgoL1 339..386 CDD:462567 19/78 (24%)
PAZ_piwi_like 387..504 CDD:239211 31/124 (25%)
Piwi_piwi-like_Euk 512..956 CDD:240016 126/477 (26%)
Blue background indicates that the domain is not in the aligned region.

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