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Protein Alignment AGO2 and ago2

DIOPT Version :10

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_001004877.1	Gene:	ago2 / 448205	XenbaseID:	XB-GENE-1001916	Length:	871	Species:	Xenopus tropicalis

Alignment Length:	847	Identity:	271/847 - (31%)
Similarity:	421/847 - (49%)	Gaps:	77/847 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 PPQQQQAAPLPL-----PPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPER-P 447
            ||......|:|.     ||:|    ..||.|:..::..|:.::|:.|:.  .|||::.|.||: |
Frog    11 PPTPTPPLPMPAYTFKPPPRP----DFGTSGRTIKLQANFFEMDIPKIE--IYHYEIDIKPEKCP 69

  Fly   448 KKFYRQAFE----QFRVDQLGGAVLAYDGKASCYSVDKLPL-NSQNPEVTVT-DRNGRTLRYTIE 506
            ::..|:..|    .|:....|.....:||:.:.|:...||: ..:..|:.|| ...|:...:.:.
Frog    70 RRVNREIVEHMVQHFKAQIFGDRKPVFDGRKNLYTAMPLPIARDKQVELEVTLPGEGKDRIFKVA 134

  Fly   507 IKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIR---VGRSFFKMSDPNNRH 568
            ||..  :.:.|::|...::.|:...|...:|.::||:.   |..::|   ||||||..|: ...:
Frog   135 IKWM--ACVSLQALHDALSGRLPSVPFETIQALDVVMR---HLPSMRYTPVGRSFFTASE-GCAN 193

  Fly   569 ELDDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYL-ERFSLKAKINNTTNLD 627
            .|..|.|...|.:|:.    ||     .||:|:|..:|..:.|:||:: |....|:.......|.
Frog   194 PLGGGREVWFGFHQSV----RPSLWKMMLNIDVSATAFYKAQPVIEFMCEVLDFKSIEEQQKPLT 254

  Fly   628 YSRR--FLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETF---EHDGKKV--TIASYF 685
            .|:|  |.:. ::|:.|..|.....:   |.|||..::|.|||.:||   :..|:.|  |:|.||
Frog   255 DSQRVKFTKE-IKGLKVEITHCGQMK---RKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYF 315

  Fly   686 HSRN-YPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKR 749
            ..|: ..|::|.|.||.||...|...||:|:|:|..||...:|....|.:.||:..|.|...|:.
Frog   316 KDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQE 380

  Fly   750 KIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYH-----------SKRFTMVKNG 803
            :|..|::....|.||.:..|||.:.:|...|:.|||.||.:.|.           :|.......|
Frog   381 EISKLMRSASFNTDPFVREFGIMVKDDMTDVTGRVLQPPSILYGGRVWEEPNAPLNKAIATPVQG 445

  Fly   804 SWRMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYR 865
            .|.|...:|   :|.|..|..|..    |:  |:.....|..|...:....:...:.:.....:.
Frog   446 VWDMRNKQFHTGIEIKVWAIACFA----PQ--RQCTEVHLKTFTEQLRKISRDAGMPIQGQPCFC 504

  Fly   866 PFTDDERSLDTIFADLKRSQH--DLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCN 928
            .:.....|::.:|..||.:..  .|.:||:|.....|..:|:..:...|:.|||::...|:| ..
Frog   505 KYAQGADSVEPMFRHLKNTYTGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQR-TT 568

  Fly   929 NQTIGNILLKINSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPY 992
            .||:.|:.||||.||.|:|:.:....|.|:.:. .:::|||||||.....:.||:..|..|.|.:
Frog   569 PQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAH 633

  Fly   993 GASYNMQYRLQRGALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELR 1056
            ...|....|:|:...|.|:|:.::..|.| :.||..| ..|..||:||||||:|||.::.:.||.
Frog   634 PNRYCATVRVQQHRQEIIQDLSAMVRELLIQFYKSTR-FKPTRIIFYRDGVSEGQFQQVLHHELL 697

  Fly  1057 CIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFM 1119
            .|::||.|:  ..:|.|..::|.||||||.|.:.......|..|:..||.||..|.||:|..|::
Frog   698 AIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDRNERVGKSGNIPAGTTVDTKITHPSEFDFYL 762

  Fly  1120 VSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRV 1184
            .||..||||::|:.|:|:.:......|.||.|||.|||.:.||.||||.|||||.|||||.|.|.
Frog   763 CSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARY 827

  Fly  1185 YL 1186
            :|
Frog   828 HL 829

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.