DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and AGO1

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_001246314.1	Gene:	AGO1 / 36544	FlyBaseID:	FBgn0262739	Length:	984	Species:	Drosophila melanogaster

Alignment Length:	908	Identity:	283/908 - (31%)
Similarity:	423/908 - (46%)	Gaps:	122/908 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 PQQQQAAPLPLPPQPAGSIKR----GTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPER-PKK 449
            |....|.|...|..|..:..|    |..|:|..:..|:..:.:.:  ...:|||:.|.|:: |:|
  Fly   117 PAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPR--GYVHHYDINIQPDKCPRK 179

  Fly   450 FYRQAFEQF--RVDQLGGAVL-AYDGKASCYSVDKLPLNSQNPEVTVT---DRNGRTLRYTIEIK 508
            ..|:..|..  ...::.|.:. .:||:.:.|:.|.||:.::..|:.||   :...|..|.||:
  Fly   180 VNREIIETMVHAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIK-- 242

  Fly   509 ETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNN-RHELDD 572
              ..:.:.|.:|...:..|....|..|:..::||:..........||||||  |.|.. .|.|..
  Fly   243 --WQAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFF--SSPEGYYHPLGG 303

  Fly   573 GYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYL-ERFSLKAKINNTTN--LDYS 629
            |.|...|.:|:.    ||     .||:|:|..:|..:.|:|::: |...:: .||....  .|..
  Fly   304 GREVWFGFHQSV----RPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIR-DINEQRKPLTDSQ 363

  Fly   630 RRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGKKV--TIASYFHSR- 688
            |......::|:.:..|.....:   |.|||..::|.||..::|.   .:|:.|  |:|.||..:
  Fly   364 RVKFTKEIKGLKIEITHCGQMR---RKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKY 425

  Fly   689 NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMN 753
            ...|::|.|.||.||...|...||:|:|:|..||...:|....|.:.|||..|.|...|:|:|.|
  Fly   426 RMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINN 490

  Fly   754 LLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMV-----------------K 801
            |::....|.|..:..||:.|:|..:.|..|||.||:::|..:..|.:                 .
  Fly   491 LVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPN 555

  Fly   802 NGSWRMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQ-----LNDFGNLIISQGKAVNISL 858
            .|.|.|.|.:|   :|.:..|..|.......|.....|:||     .||.|..||.|......:.
  Fly   556 QGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYAT 620

  Fly   859 DSDVTYRPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTV 923
            ..|.....|    |.|...|..|:     |.:|::|.....|..:|:..:...|:.|||::...|
  Fly   621 GPDQVEPMF----RYLKITFPGLQ-----LVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNV 676

  Fly   924 ERKCNNQTIGNILLKINSKLNGINH--------KIKDDPRLPMMKNTMYIGADVTHPSPDQREIP 980
             .|.:.||:.|:.||||.||.|||.        |:.::|       .:::|||||||.....:.|
  Fly   677 -NKTSPQTLSNLCLKINVKLGGINSILVPSIRPKVFNEP-------VIFLGADVTHPPAGDNKKP 733

  Fly   981 SVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNAY-PDHIIYYRDGVSD 1044
            |:..|..|.|.:.:.|....|:|:...|.|:::.|:..|.|.::.:....| |..||.||||||:
  Fly   734 SIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSE 798

  Fly  1045 GQFPKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDR 1107
            ||||.:...||..|::||.|:  ..:|.|..::|.||||||.|.:.....|.|..|:..||.||.
  Fly   799 GQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDV 863

  Fly  1108 TIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPA 1172
            .|.||.|..|::.|||.||||::|:.|:|:.:..:.|.|.||.|||.|||.:.||.||||.||||
  Fly   864 GITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPA 928

  Fly  1173 YLAHLVAARGRVYLTGTNRFLDLKKEY-------------------AKRTIVPEFMKKNPMYF 1216
            |.|||||.|.|.:|        ::||:                   ..|.|......|..|||
  Fly   929 YYAHLVAFRARYHL--------VEKEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYF 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	265/826 (32%)
		ArgoN	411..543	CDD:293095	33/138 (24%)
		ArgoL1	554..601	CDD:285861	20/52 (38%)
		PAZ	605..719	CDD:239207	35/122 (29%)
		Piwi_ago-like	764..1186	CDD:240015	161/457 (35%)
AGO1	NP_001246314.1	ArgoN	146..275	CDD:406799	31/134 (23%)
		ArgoL1	285..335	CDD:400854	21/55 (38%)
		PAZ_argonaute_like	336..456	CDD:239212	35/123 (28%)
		Piwi_ago-like	502..942	CDD:240015	161/456 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14925at7147
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.870