Protein Alignment AGO2 and AGO3

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Alignment Length: 849
• Identity: 202/849 - (23%)
• Similarity: 332/849 - (39%)
• Gaps: 164/849 - (19%)

  Fly   411 GTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPERPKKFYRQAFEQFRVDQLGGAVLAYDGKAS 475
            |:.|....:..|||.|...:...| ::|:|:..|.......|..:.....|:||| ...:||. :
  Fly   122 GSKGSSVNIYCNYLKLTTDESKGV-FNYEVRFFPPIDSVHLRIKYLNDHKDKLGG-TKTFDGN-T 183

  Fly   476 CYSVDKLPLNSQNPEVTVTDRNGRTLRYTIEIKETGDSTIDLKSL---------TTYMNDRIFDK 531
            .|    ||:...|             :.|:.|.:..|..:.::.|         .|.:.:.:||:
  Fly   184 LY----LPILLPN-------------KMTVFISKAEDVELQIRILYKKKEEMRNCTQLYNILFDR 231

  Fly   532 PMRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPN----NRHELDDGYEALVGLYQAFMLGDRPFL 592
            .|:.:..|             :..|..|..|.|.    .:.|:..||...|..|:..::     |
  Fly   232 VMKVLNYV-------------KFDRKQFDPSRPKIIPLAKLEVWPGYVTAVDEYKGGLM-----L 278

  Fly   593 NVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVY 657
            ..|:||:.. ....::|.|.....:       |:::.:......|.| |:|.|...:     |.|
  Fly   279 CCDVSHRIL-CQKTVLEMLVDLYQQ-------NVEHYQESARKMLVG-NIVLTRYNN-----RTY 329

  Fly   658 RVNGLSRAPASSETFEHDGKKVTIASYFHSRNYPLKFPQLHCLNVGS-------SIKS------- 708
            ::|.:......:..||   .|....||..      .:.|.|.:|:..       |||.
  Fly   330 KINDICFDQNPTCQFE---IKTGCTSYVE------YYKQYHNINIKDVNQPLIYSIKKSRGIPAE 385

  Fly   709 ------ILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPT-- 765
                  .|:| |||.:     ...:|.......:::..||.|.|...:....|..|..|:..|
  Fly   386 RENLQFCLIP-ELCYL-----TGLRDEVRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPA 444

  Fly   766 ----ISRFGIRIANDFIVVSTRVLSPPQVEYHSK------RFTMVKNGSWRMDGMKFLEPKPKAH 820
                ::.:|:.:.|:...:|.|.:...|: |.||      |.......:...:.:|.:      |
  Fly   445 AQEILNSWGLSLTNNSNKISGRQMDIEQI-YFSKISVSAGRSAEFSKHAVTNEMLKVV------H 502

  Fly   821 KCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVN----ISLDSDVTYRPFTDDERSLDTIFADL 881
            ....:....|:.|:...:.|::......|.|..::    ||||.|           .:|.....|
  Fly   503 LSKWIIIHLRNYRQAATSLLDNMKQACESLGMNISNPTMISLDHD-----------RIDAYIQAL 556

  Fly   882 KR--SQHDLAIVIIPQFRIS--YDTIKQKAELQHGILTQCIKQFTVERKCN-NQTIGNILLKINS 941
            :|  :.:...:|.|...|..  |..||:....:..|.:|.|...|::.... ...:..|:|::|.
  Fly   557 RRNITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDLKIRSVVQKIVLQMNC 621

  Fly   942 KLNGINHKIKDDPRLPMMKNTMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQY--RLQR 1004
            ||.|....:|    :| .||.|..|.|..| .|..|. .||....||   ..:||:..|  .:.:
  Fly   622 KLGGSLWTVK----IP-FKNVMICGIDSYH-DPSNRG-NSVAAFVAS---INSSYSQWYSKAVVQ 676

  Fly  1005 GALEEIEDMFSITLE-HLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKVGCK 1068
            ...|||.:..|.:.| .|::|::.....|.:||.||||:.|||.....|.|:...:..|   |.:
  Fly   677 TKREEIVNGLSASFEIALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVC---GNR 738

  Fly  1069 PKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTR 1133
            .||..::|.||.:||.|....:...|..    ||||||:.|...|...||:||....|||..||.
  Fly   739 IKISYIVVQKRINTRIFSGSGIHLENPL----PGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTH 799

  Fly  1134 YNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYLTGTNRFLDLKKE 1198
            |.|:.:..|...|::|:|:|.||.::.....:|..||....||.:|     ||.|.:...|:.:.
  Fly   800 YVVLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLA-----YLIGQSIQRDVAEA 859

  Fly  1199 YAKR 1202
            .:::
  Fly   860 LSEK 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	15/80 (19%)
		ArgoL1	554..601	CDD:462567	13/50 (26%)
		PAZ	605..719	CDD:239207	27/133 (20%)
		Piwi_ago-like	764..1186	CDD:240015	120/445 (27%)
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	32/161 (20%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	129/477 (27%)