DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AGO2 and Piwil4

DIOPT Version :9

Sequence 1:NP_730054.1 Gene:AGO2 / 39683 FlyBaseID:FBgn0087035 Length:1217 Species:Drosophila melanogaster
Sequence 2:NP_001355760.1 Gene:Piwil4 / 330890 MGIID:3041167 Length:848 Species:Mus musculus


Alignment Length:925 Identity:208/925 - (22%)
Similarity:377/925 - (40%) Gaps:181/925 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 GHQQGRQGQEGGYQQR--------PSGQQQGG--------HQQGRQGQEGG---YQQRPPGQQPN 376
            |...|...:|.|...|        |...:.||        ::.|....:||   .::|..|:|  
Mouse    11 GITTGHSAREVGRSSRDLMVTSASPGDSEAGGGTSVISQPYELGVSSGDGGRTFMERRGKGRQ-- 73

  Fly   377 QTQSQGQYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVK 441
                  .::..|...:::...:.       ..|.|:.|.|.::..|..:|||.:...: |.|.|.
Mouse    74 ------DFEELGVCTREKLTHVK-------DCKTGSSGIPVRLVTNLFNLDLPQDWQL-YQYHVT 124

  Fly   442 IMPERPKKFYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVTDRNGRTLRYTIE 506
            ..|:...:..|.|. .:....|.....|:|| ||.:..:|  |:.:..|:|...:.|.|::.|: 
Mouse   125 YSPDLASRRLRIAL-LYNHSILSDKAKAFDG-ASLFLSEK--LDQKVTELTSETQRGETIKITL- 184

  Fly   507 IKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAI-RVGRSFFKMSD----PNN 566
                        :||:    ::|......:|...|:......|.:: ::||:|:|.|:    |..
Mouse   185 ------------TLTS----KLFPNSPVCIQFFNVIFRKILKNLSMYQIGRNFYKPSEPVEIPQY 233

  Fly   567 RHELDDGYEALVGLYQAFMLGDRPFLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRR 631
            :..|..|:...|..:::.:|     .|.|:::|... :..:::::....|:..::..|.:.:.: 
Mouse   234 KLSLWPGFAISVSHFESKLL-----FNADVNYKVLR-NETVLDFMTDLCLRTGMSCFTEMCHKQ- 291

  Fly   632 FLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE-HDGKKVTIASYFHSRNY----- 690
                 |.|: ||.|...:     :.||::.:..:...::.|: .||.:||...|: .:.|     
Mouse   292 -----LVGL-VVLTRYNN-----KTYRIDDIDWSVKPTQAFQKRDGSEVTYVDYY-KQQYDITLS 344

  Fly   691 PLKFPQLHCL-----NVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNV---- 746
            .|..|.|..|     |..|..:.:.|..|||.:     ......||....::|..|..|.:    
Mouse   345 DLNQPVLVSLLKRKRNDNSEPQMVHLMPELCFL-----TGLSSQATSDFRLMKAVAEETRLSPVG 404

  Fly   747 RKRKIMNLLQYFQHNLDPTISRF-----GIRIANDF-----IVVSTRVLSPPQVEYHSKRFTMVK 801
            |::::..|:...|.|   .::||     |:...:..     :|.|.::|    ::.|:.:.....
Mouse   405 RQQQLARLVDDIQRN---PVARFELETWGLHFGSQLSLTGRVVPSEKIL----LQDHTCQPAFAA 462

  Fly   802 NGSWRMDGMKFLEPKP----------KAHKC--AVLYCDPRSGRKM----NYTQLNDFGNLIISQ 850
            :.|..|...|.|..:|          :|...  |.|.|..|.|..|    .|.::........:.
Mouse   463 DWSKDMRSCKVLSSQPLNRWLIVCCNRAEHLIEAFLSCLRRVGGSMGFNVGYPKIIKVDETPAAF 527

  Fly   851 GKAVNISLDSDVTYRPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRIS-YDTIKQKAELQHGIL 914
            .:|:.:..|.||                        .|.:.|:|..:.: ||:||:.......:.
Mouse   528 LRAIQVHGDPDV------------------------QLVMCILPSNQKNYYDSIKKYLSSDCPVP 568

  Fly   915 TQCIKQFTVERKCNNQTIG-NILLKINSKLNGINHKIKDDPRLPMMKNTMYIGADVTHPSPDQRE 978
            :||:...|:.::....::. .|.:::..||.|....::    :| :|:.|.:|.|:...:.::..
Mouse   569 SQCVLTRTLNKQGTMLSVATKIAMQMTCKLGGELWSVE----IP-LKSLMVVGIDICRDALNKNV 628

  Fly   979 IPSVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLE-HLRVYKEYRNAYPDHIIYYRDGV 1042
            :  |||..||.:.....:..:..|||.| .:|.|...:.:. .|..:..:.:..|..|:.|||||
Mouse   629 V--VVGFVASINSRITRWFSRCVLQRTA-ADIADCLKVCMTGALNRWYRHNHDLPARIVVYRDGV 690

  Fly  1043 SDGQFPKIKNEELRCIKQACDKVGCKPKIC---CVIVVKRHHTRFFPSGDVTTSNKFNNVDP-GT 1103
            .:||...:...|:..:.::..:.|...:.|   .|:|.||...|.|.|.|.|..|     .| ||
Mouse   691 GNGQLKAVLEYEVPQLLKSVTECGSDARSCRLSVVVVRKRCLLRLFASTDHTVQN-----PPLGT 750

  Fly  1104 VVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSY 1168
            |||.....|....|:::|..|.:||..||.||||.:...|..|.:|:||:.|||::......:|.
Mouse   751 VVDSEATRPEWYDFYLISQTANRGTVSPTHYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGLISV 815

  Fly  1169 PAPAYLAH----LVA 1179
            |||...||    |||
Mouse   816 PAPCQYAHKLTFLVA 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AGO2NP_730054.1 PLN03202 411..1180 CDD:215631 192/826 (23%)
ArgoN 411..543 CDD:293095 31/131 (24%)
ArgoL1 554..601 CDD:285861 13/50 (26%)
PAZ 605..719 CDD:239207 26/124 (21%)
Piwi_ago-like 764..1186 CDD:240015 112/453 (25%)
Piwil4NP_001355760.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52 8/40 (20%)
PAZ 266..403 CDD:198017 31/154 (20%)
Piwi_piwi-like_Euk 389..831 CDD:240016 119/486 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.