Protein Alignment AGO2 and LOC3291361

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_061517134.1
• Gene: LOC3291361 / 3291361
• VectorBaseID: AGAMI1_005734
• Length: 1058
• Species: Anopheles gambiae
• Alignment Length: 1227
• Identity: 450/1227 - (36%)
• Similarity: 617/1227 - (50%)
• Gaps: 228/1227 - (18%)

  Fly    28 KQQQQRQQQPQQLQQPQQLQQPQQLQQPQQQQQQQPHQQQQQSSRQQPSTSSGGSRASGFQQGGQ 92
            :|||..|||||...||||.||||  |:||||||.||.|:.||   |||.::
Mosquito    23 QQQQPPQQQPQPQPQPQQQQQPQ--QRPQQQQQPQPQQRPQQ---QQPQST-------------- 68

  Fly    93 QQKSQDAEGWTAQKKQGKQQVQGWTKQGQQGGHQQGRQGQDGGYQQRPPGQQQGGHQQGRQGQEG 157
                                                       .||.||  ||.||.|.:|..:|
Mosquito    69 -------------------------------------------LQQGPP--QQQGHAQKQQQPQG 88

  Fly   158 GYQQRPPGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQQGGHQQGRQ 222
                 ||.|||         |:|..|::          |.:|.|.||.||         ||||
Mosquito    89 -----PPQQQQ---------QQGNPQKK----------QKKQPQSGGPQQ---------HQQG-- 118

  Fly   223 GQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQQGGHQQGRQGQEGGYQQRPPGQQQGGHE 287
                     ||.|||         |....|..||.||               ||:|
Mosquito   119 ---------PSQQQQ---------QHAQKQHEPPQQQ---------------QQQP--------- 141

  Fly   288 QGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPSGQQQ 352
                       |||..|||   ||         ||||..|||   |||...|:...||||..||.
Mosquito   142 -----------QRPQQQQQ---QQ---------QQRPQQQQQ---QQGPPQQQQQQQQRPRQQQH 180

  Fly   353 --------GGHQQGRQGQEGGYQQRPPGQQPNQTQSQGQYQSRGPPQQQQAAPLPLPPQPAGSIK 409
                    .|....|.......:....|....||..:.....|...::.:...|    :|. .::
Mosquito   181 KPAVPAAATGSAVHRDASVASTKSSSSGDGTLQTIEENLGAMRIAKEKIRRTDL----RPV-LVR 240

  Fly   410 RGTIGKPGQ---VGINYLDLDLSKMPSVAYHYDVKIMPERPKKFYRQAFEQFRVDQLGGAVLAYD 471
            ||..||.|:   |..|:..|.|.|:...||||||.|.|:|||||||..|.||..:...||:||:|
Mosquito   241 RGAHGKRGKPVSVEANFFRLLLDKLKGTAYHYDVAIEPDRPKKFYRPVFAQFCRENYPGAMLAFD 305

  Fly   472 GKASCYSVDKLPLNSQNPEVTVTDRNGRTLRYTIEIKETGDSTIDLKSLTTYM--NDRIFDKPMR 534
            |:.:.|:..||. :.:...|...|..|:...||:::||.  :.:||..|.|||  |:....|||.
Mosquito   306 GQKNAYTTRKLS-DKKAKVVFQPDDGGKQREYTVQVKEA--AQLDLGVLKTYMKSNEETMAKPMS 367

  Fly   535 AMQCVEVVLASPCHNKA--IRVGRSFFKMSDPNNRHELDDGYEALVGLYQAFMLGDRPFLNVDIS 597
            |:||::|||.|...|..  :|..|:.:.:  |....::..|:|...||:|:.:||.||:||||:|
Mosquito   368 AIQCLDVVLRSAYENNPNFVRFKRAVYAV--PRQSIDIGRGHELWFGLFQSALLGSRPYLNVDVS 430

  Fly   598 HKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGL 662
            ||:||:..|:::.:..|: :.:::..:.  :.::.|..||:|::||||.|.: :.|.|: |.|||
Mosquito   431 HKAFPMGAPVLKVIGDFN-RGQVDQVSG--WVQQELHSFLKGMDVVYTNPTT-RMAKRM-RCNGL 490

  Fly   663 SRAPASSETFE-HDGKKVTIASYFHSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALN 725
             |.|||.:.|: .||.::::|.||..: |:.|::|.|..|:|||:::|:.:|.|||.|..|||||
Mosquito   491 -REPASQQMFKLEDGTRLSVADYFARKLNFRLRYPNLPVLHVGSTVRSVYVPAELCDIPAGQALN 554

  Fly   726 RKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQV 790
            :.:......::|:|||||...|||||::|....|:|..||:..|||.:.|:|..|..|::..|.:
Mosquito   555 KNNPEECTRDIIRYAATSAPERKRKILDLASQIQYNKCPTLLDFGITVGNEFEKVPARIIDAPPI 619

  Fly   791 EYHSKRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMN---YTQ---LNDFGNLIIS 849
            ||........:.|.||.:|..|:.|..:..|      .|...|.:|   ||.   :..||.::.|
Mosquito   620 EYARGEKIPPQRGVWRAEGKNFIVPSTELSK------RPLRWRILNLDLYTNEATVKKFGEMLQS 678

  Fly   850 QGKAVNISL---DSDVTY---RPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAE 908
            |....|:.:   |...||   |...:..|.:.|:..::||.:..:.||::|....:|..:|||||
Mosquito   679 QAMRCNVQMEPFDMAKTYVLVRDMRNCLRDIGTLLQNIKREEPAVTIVVLPSRGDAYAKVKQKAE 743

  Fly   909 L---QHGILTQCIKQFTVERK-CNNQTIGNILLKINSKLNGINHKIKDDPRLPMMK-NTMYIGAD 968
            |   :.|:||||:|..||.:| .:..|:.||:||||:|.||.||.|......|:.: ..||||||
Mosquito   744 LASERIGLLTQCVKGMTVAKKGTDMSTLNNIMLKINAKTNGTNHCISQVAVPPLGRGKVMYIGAD 808

  Fly   969 VTHPSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNAYPD 1033
            ||||..:..  ||||||||.:|..|..||...|||....|.|.|:.:|....|.:||:|..|.|:
Mosquito   809 VTHPLSENE--PSVVGVAALYDLTGFRYNCSVRLQGARDEMIRDLENIVQRQLLLYKQYNGALPE 871

  Fly  1034 HIIYYRDGVSDGQFPKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKF 1096
            .|:|||||||||||.:|...||:.:..|..:|  |.||.:..::|.|||||||||.....|..|.
Mosquito   872 RIMYYRDGVSDGQFAEILTIELQALHAAIARVEPGYKPAVTFIVVQKRHHTRFFPQPGCPTEGKN 936

  Fly  1097 NNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPR 1161
            .||.|||:||..|..|:..:|::|||.|:||.||||:|.|:.:..|...|.||.|||||||:|.|
Mosquito   937 GNVPPGTIVDSEITTPDRYEFYLVSHAAVQGVAKPTKYVVLYDDSNCHPDSLQALTYNLCHLFAR 1001

  Fly  1162 CNRSVSYPAPAYLAHLVAARGRVYLTGTN-RFLDLKKEYAKRTIVPEFMKKNPMYFV 1217
            |||:||||||.|.|||.|.|||||:.... ...||:..|....|:.......||:||
Mosquito  1002 CNRAVSYPAPTYYAHLAAYRGRVYIKDRRINMNDLENAYRDIQIIDTVNNSTPMFFV 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	26/73 (36%)
		ArgoL1	554..601	CDD:462567	18/46 (39%)
		PAZ	605..719	CDD:239207	40/115 (35%)
		Piwi_ago-like	764..1186	CDD:240015	190/440 (43%)
LOC3291361	XP_061517134.1	None