DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and Ago3

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_001258122.1	Gene:	Ago3 / 313593	RGDID:	1309163	Length:	860	Species:	Rattus norvegicus

Alignment Length:	846	Identity:	271/846 - (32%)
Similarity:	415/846 - (49%)	Gaps:	77/846 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 SRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPER-PKK 449
            |.||...|   ||.:.|:..|   .||:|||.::..|...:::.|:.  .|.|:|.|.|:: |::
  Rat     5 SAGPIGAQ---PLLIVPRRPG---YGTMGKPIKLLANCFQVEIPKID--VYLYEVDIKPDKCPRR 61

  Fly   450 FYRQA----FEQFRVDQLGGAVLAYDGKASCYSVDKLPL--NSQNPEVTVTDRNGRTLRYTIEIK 508
            ..|:.    .:.|:|...|.....||||.|.|:.:.||:  ...:.:||:....|:...:.:.:|
  Rat    62 VNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSVK 126

  Fly   509 ETGDSTIDLKSLTTYMNDRI------FDKPM--RAMQCVEVVLASPCHNKAIRVGRSFFKMSDPN 565
            ..  |.:....|...:..|.      .|||:  ..:..|:|||......|...||||||...:..
  Rat   127 FV--SRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGY 189

  Fly   566 NRHELDDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYLERFSLKAKINNTTN 625
            : |.|..|.|...|.:|:.    ||     .||:|:|..:|..:.|:|:::      .::.:..|
  Rat   190 D-HPLGGGREVWFGFHQSV----RPAMWKMMLNIDVSATAFYKAQPVIQFM------CEVLDIHN 243

  Fly   626 LDYSRRFLEPF--------LRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGKKV 679
            :|...|.|...        ::|:.|..|...:.:   |.|||..::|.|||.:||.   .:|:.|
  Rat   244 IDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMR---RKYRVCNVTRRPASHQTFPLQLENGQTV 305

  Fly   680 --TIASYFHSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAA 741
              |:|.||..: ...||:|.|.||.||...|...||:|:|:|..||...:|....|.:.|||..|
  Rat   306 ERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATA 370

  Fly   742 TSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMV--KNGS 804
            .|...|:.:|..|::...:..||.:..|..::.::...|:.|||..|.::|..:..|:.  .:|.
  Rat   371 RSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGV 435

  Fly   805 WRMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRP 866
            |.|.|.:|   :|.|..|..|..      :.|:.....|..|.:.:....|...:.:.....:..
  Rat   436 WDMRGKQFHTGVEIKMWAIACFA------TQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCK 494

  Fly   867 FTDDERSLDTIFADLKR--SQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNN 929
            :.....|::.:|..||.  |...|.|||:|.....|..:|:..:...|:.|||::...| .|.:.
  Rat   495 YAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNV-IKTSP 558

  Fly   930 QTIGNILLKINSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPYG 993
            ||:.|:.||||.||.|||:.:....|..:.:. .:::|||||||.....:.||:..|..|.|.:.
  Rat   559 QTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHP 623

  Fly   994 ASYNMQYRLQRGALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRC 1057
            :.|....|:||...|.|:|:.|:..|.| :.||..| ..|..||:||||||:|||.::...||..
  Rat   624 SRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTR-FKPTRIIFYRDGVSEGQFRQVLYYELLA 687

  Fly  1058 IKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMV 1120
            |::||..:  ..:|.|..::|.||||||.|.:.......:..|:..||.||..|.||.|..|::.
  Rat   688 IREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLC 752

  Fly  1121 SHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVY 1185
            ||..||||::|:.|:|:.:......|.||.|||.|||.:.||.||||.|||||.|||||.|.|.:
  Rat   753 SHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYH 817

  Fly  1186 L 1186
            |
  Rat   818 L 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	259/813 (32%)
		ArgoN	411..543	CDD:293095	37/146 (25%)
		ArgoL1	554..601	CDD:285861	18/51 (35%)
		PAZ	605..719	CDD:239207	38/127 (30%)
		Piwi_ago-like	764..1186	CDD:240015	151/432 (35%)
Ago3	NP_001258122.1	ArgoN	73..167	CDD:406799	23/95 (24%)
		ArgoL1	177..227	CDD:400854	19/54 (35%)
		PAZ_argonaute_like	228..348	CDD:239212	38/128 (30%)
		Piwi_ago-like	393..818	CDD:240015	151/432 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930