Protein Alignment AGO2 and Piwil2

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_006252333.2
• Gene: Piwil2 / 306011
• RGDID: 1306964
• Length: 1005
• Species: Rattus norvegicus
• Alignment Length: 947
• Identity: 226/947 - (23%)
• Similarity: 358/947 - (37%)
• Gaps: 251/947 - (26%)

  Fly   347 PSGQQQGGHQQGRQGQEGGYQQRPPGQQPNQTQSQGQYQSRGPPQQQQAAPLPLPPQPAGS---- 407
            |.|:..|...:|        ..:||        |.....:|.||:      ||.||..:.:
  Rat   187 PLGRAAGSIGRG--------VDKPP--------SAFGLTARDPPR------LPQPPTLSPTSLHS 229

  Fly   408 -----------------IKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPERPKKFYRQAF 455
                             :|:|:.|.|..:|:|.:.:....  ...|.|.|...|....|..|  |
  Rat   230 SDPPPVLTIERKEKELLVKQGSKGTPQSLGLNLIKIQCHN--EAVYQYHVTFSPNVECKSMR--F 290

  Fly   456 EQFRVDQ-LGGAVLAYDGKASCYSVDKLPLNSQNPEVTVTDRNGRTLRYTIEIK---ETGDSTID 516
            ...:..| :.|.|.|:||     |:..||:.               |:..:|:|   :|.|:.|.
  Rat   291 GMLKDHQSVTGNVTAFDG-----SILYLPVK---------------LQQLVELKSQRKTDDAEIS 335

  Fly   517 LKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIR----------VGRSFFKMSDPNN----- 566
            :|...|.:.:...|            |..|.:|...|          |||:|:   ||.:
  Rat   336 IKIQLTKILEPCSD------------LCIPFYNVVFRRVMKLLDMKLVGRNFY---DPTSAMVLQ 385

  Fly   567 RHELD--DGYEALV-----GLYQAFMLGDRPFLNVDISHKSFPISMPMIEYLERFSLKAKINNTT 624
            :|.|.  .||.|.:     ||          ||..|:|||                   .|.|.:
  Rat   386 QHRLQIWPGYAASIRRTDGGL----------FLLADVSHK-------------------VIRNDS 421

  Fly   625 NLDYSRRFLEPFLRGINVVYTP-PQSFQSA---------------PRVYRVNGL--SRAPASSET 671
            .||.           ::.:|.. .:.||..               .|.||::.:  ::.|..|..
  Rat   422 VLDV-----------MHAIYQQNKEHFQDECSKLLVGSIVITRYNNRTYRIDDVDWNKTPKDSFV 475

  Fly   672 FEHDGKKVTIASYFHSRNY---------PLKF--PQLHCLNVGSSIKSILLPIELCSIEEGQALN 725
            .. |||::|...|: |:||         ||..  |.....|.|:.:|..:|.:...|...|....
  Rat   476 MS-DGKEITFLEYY-SKNYGITVKEDDQPLLIHRPSERQNNHGTLLKGEILLLPELSFMTGIPEK 538

  Fly   726 RKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHN--LDPTISRFGIRIANDFIVVSTRVLSPP 788
            .|.....:.::.:....|.......:..|||....|  .:..::|:|:.:..|...:..|:|...
  Rat   539 MKKDFRAMKDLTQQINLSPKQHHSALECLLQRISQNETANNELTRWGLSLQKDVHKIEGRLLPME 603

  Fly   789 QVEYHSKRFTMVKNGSW----RMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLI-- 847
            ::...:..|...::.:|    ..|......|   .|..|:.|  |:  |.|:  |..:..|::
  Rat   604 RINLRNTSFVTSEDLNWVKEVTRDASILTIP---MHFWALFY--PK--RAMD--QARELVNMLEK 659

  Fly   848 --------ISQGKAVNISLDSDVTY----RPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRISY 900
                    ||....|.:..|...||    :.....|..:..:...:..::.||           |
  Rat   660 IAGPIGMRISPPAWVELKDDRIETYIRTIQSLLGVEGKIQMVVCIIMGTRDDL-----------Y 713

  Fly   901 DTIKQKAELQHGILTQCIKQFTVERKCNNQTIG-NILLKINSKLNGINHKIKDDPRLPMMKNTMY 964
            ..||:...:|..:.:|.|...|:.:....:::. .|||::|.||.|....: |.|    :|..|.
  Rat   714 GAIKKLCCVQSPVPSQVINVRTIGQPTRLRSVAQKILLQMNCKLGGELWGV-DIP----LKQLMV 773

  Fly   965 IGADVTH-PSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYR 1028
            ||.||.| ||   |.:.||||..||.:.....:..:...|....|.::.:....:..|:.|.|..
  Rat   774 IGMDVYHDPS---RGMRSVVGFVASINLTLTKWYSRVVFQMPHQEIVDSLKLCLVGSLKKYYEVN 835

  Fly  1029 NAYPDHIIYYRDGVSDGQFPKIKNEEL----RCIKQACDKVGCKPKICCVIVVKRHHTRFF---P 1086
            :..|:.|:.|||||||||...:.|.|:    :|. :|.|..  .||:...:|.|:..|..:   |
  Rat   836 HCLPEKIVVYRDGVSDGQLKTVANYEIPQLQKCF-EAFDNY--HPKMVVFVVQKKISTNLYLAAP 897

  Fly  1087 SGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQL 1151
            ...||.|       ||||||.||.....:.|::::|...||...||.|..:.||.||..|.:|:|
  Rat   898 DHFVTPS-------PGTVVDHTITSCEWVDFYLLAHHVRQGCGIPTHYICVLNTANLSPDHMQRL 955

  Fly  1152 TYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYLTG 1188
            |:.||||:.....::..|||...||.:|     :|:|
  Rat   956 TFKLCHMYWNWPGTIRVPAPCKYAHKLA-----FLSG 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	14/74 (19%)
		ArgoL1	554..601	CDD:462567	19/58 (33%)
		PAZ	605..719	CDD:239207	28/142 (20%)
		Piwi_ago-like	764..1186	CDD:240015	121/448 (27%)
Piwil2	XP_006252333.2	ArgoL1	371..418	CDD:462567	19/78 (24%)
		PAZ_piwi_like	419..536	CDD:239211	28/129 (22%)
		Piwi_piwi-like_Euk	544..988	CDD:240016	128/487 (26%)