DRSC/TRiP Functional Genomics Resources

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Protein Alignment AGO2 and Ago4

DIOPT Version :9

Sequence 1:NP_730054.1 Gene:AGO2 / 39683 FlyBaseID:FBgn0087035 Length:1217 Species:Drosophila melanogaster
Sequence 2:XP_006238924.1 Gene:Ago4 / 298533 RGDID:1304583 Length:861 Species:Rattus norvegicus


Alignment Length:847 Identity:272/847 - (32%)
Similarity:414/847 - (48%) Gaps:82/847 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   388 GPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPE-RPKKFY 451
            |||     |.|..||:..|   .||:|||.::..|:..:.:.|:.  .|||||.|.|| ||::..
  Rat     7 GPP-----ASLFQPPRRPG---LGTVGKPIRLLANHFQVQIPKID--VYHYDVDIKPEKRPRRVN 61

  Fly   452 RQAFE----QFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVT-DRNGRTLRYTIEIKETG 511
            |:..:    .|::...|.....||||.:.|:...||:.....::.|| ...|:...:.:.::.. 
  Rat    62 REVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWV- 125

  Fly   512 DSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIR---VGRSFFKMSDPNN-RHELDD 572
             |.:.|:.|...:...:.:.|..::|.::|:..   |..::|   ||||||  |.|.. .|.|..
  Rat   126 -SVVSLQLLLEALAGHLSEVPDDSVQALDVITR---HLPSMRYTPVGRSFF--SPPEGYYHPLGG 184

  Fly   573 GYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYLERFSLKAKINNTTN--LDYSR 630
            |.|...|.:|:.    ||     .||:|:|..:|..:.|:||::........||..|.  .|..|
  Rat   185 GREVWFGFHQSV----RPAMWKMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQR 245

  Fly   631 RFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGK--KVTIASYFHSR-N 689
            ......:||:.|..|.....:   |.|||..::|.|||.:||.   .:|:  :.|:|.||..: |
  Rat   246 VKFTKEIRGLKVEVTHCGQMK---RKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYN 307

  Fly   690 YPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNL 754
            ..||:..|.||.||...|...||:|:|:|..||...:|....|.:.|||..|.|...|:.:|..|
  Rat   308 LQLKYSHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRL 372

  Fly   755 LQYFQHNL----DPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMV--KNGSWRMDGMKF- 812
            ::  .:::    ||.:..|||.:.|:...:..|||..|.::|..:..|:.  ..|.|.|.|.:| 
  Rat   373 VK--SNSVLGGPDPYLKEFGIVVHNEMTELMGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFY 435

  Fly   813 --LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLD 875
              :|.|..|..|..    |:  ::.....|..|.:.:....|...:.:.....:..:.....|::
  Rat   436 AGIEIKVWAVACFA----PQ--KQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVE 494

  Fly   876 TIFADLKRSQ--HDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLK 938
            .:|..||.:.  ..|.:||:|.....|..:|:..:...|:.|||::...|. |.:.||:.|:.||
  Rat   495 PMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVV-KTSPQTLSNLCLK 558

  Fly   939 INSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYRL 1002
            ||:||.|||:.:....|..:.:. .:::|||||||.....:.||:..|..|.|.:.:.|....|:
  Rat   559 INAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRV 623

  Fly  1003 QRG----------ALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELR 1056
            |..          :.|.::|:.|:..|.| :.||..| ..|..|||||.|||:||..::...||.
  Rat   624 QTSRQEIAQELLFSQEVVQDLTSMARELLIQFYKSTR-FKPTRIIYYRGGVSEGQMKQVAWPELI 687

  Fly  1057 CIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFM 1119
            .|::||..:  ..:|.|..::|.||||||.|.:.......|..||..||.||.||.||:|..|::
  Rat   688 AIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYL 752

  Fly  1120 VSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRV 1184
            .||..||||::|:.|.|:.:......|.||.|||.|||.:.||.||||.|||||.|.|||.|.|.
  Rat   753 CSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARY 817

  Fly  1185 YL 1186
            :|
  Rat   818 HL 819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AGO2NP_730054.1 PLN03202 411..1180 CDD:215631 260/816 (32%)
ArgoN 411..543 CDD:293095 36/137 (26%)
ArgoL1 554..601 CDD:285861 20/52 (38%)
PAZ 605..719 CDD:239207 40/121 (33%)
Piwi_ago-like 764..1186 CDD:240015 150/442 (34%)
Ago4XP_006238924.1 PLN03202 15..860 CDD:215631 267/834 (32%)
ArgoN 18..155 CDD:293095 36/143 (25%)
ArgoL1 167..216 CDD:285861 21/54 (39%)
PAZ_argonaute_like 217..337 CDD:239212 40/122 (33%)
Piwi_ago-like 384..819 CDD:240015 150/442 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58336
OrthoDB 1 1.010 - - D159407at2759
OrthoFinder 1 1.000 - - FOG0000468
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22891
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
66.030

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