DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and AGO2

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	XP_011515270.2	Gene:	AGO2 / 27161	HGNCID:	3263	Length:	918	Species:	Homo sapiens

Alignment Length:	898	Identity:	282/898 - (31%)
Similarity:	439/898 - (48%)	Gaps:	82/898 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 QRPSGQQQGGHQQGRQGQEGGYQQRPPGQQPN----------QTQSQGQYQSRGPPQQQQAAPLP 399
            :||. ..|..|:..|.|.:.......|.|:..          :.:.:.:.|.|..| ...:.|:|
Human     5 RRPH-PSQWAHRVSRTGFQSCTLHPLPLQRSGASTFLRLVLAEHKHKARCQCRAAP-CLPSVPIP 67

  Fly   400 L-PPQPAGSIKR-----------GTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPER-PKKFY 451
            | ||.|...|:.           ||.|:..::..|:.::|:.|:.  .|||::.|.||: |::..
Human    68 LAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKID--IYHYELDIKPEKCPRRVN 130

  Fly   452 RQAFE----QFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVT-DRNGRTLRYTIEIKETG 511
            |:..|    .|:....|.....:||:.:.|:...||:.....|:.|| ...|:...:.:.||..
Human   131 REIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWV- 194

  Fly   512 DSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIR---VGRSFFKMSDPNNRHELDDG 573
             |.:.|::|...::.|:...|...:|.::||:.   |..::|   ||||||..|: ...:.|..|
Human   195 -SCVSLQALHDALSGRLPSVPFETIQALDVVMR---HLPSMRYTPVGRSFFTASE-GCSNPLGGG 254

  Fly   574 YEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYL-ERFSLKAKINNTTNLDYSRR- 631
            .|...|.:|:.    ||     .||:|:|..:|..:.|:||:: |....|:.......|..|:|
Human   255 REVWFGFHQSV----RPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRV 315

  Fly   632 -FLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETF---EHDGKKV--TIASYFHSRN- 689
             |.:. ::|:.|..|.....:   |.|||..::|.|||.:||   :..|:.|  |:|.||..|:
Human   316 KFTKE-IKGLKVEITHCGQMK---RKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHK 376

  Fly   690 YPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNL 754
            ..|::|.|.||.||...|...||:|:|:|..||...:|....|.:.||:..|.|...|:.:|..|
Human   377 LVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKL 441

  Fly   755 LQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEY--HSKRFTMVKNGSWRMDGMKF---LE 814
            ::....|.||.:..|||.:.::...|:.|||.||.:.|  .:|.......|.|.|...:|   :|
Human   442 MRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIE 506

  Fly   815 PKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLDTIFA 879
            .|..|..|..    |:  |:.....|..|...:....:...:.:.....:..:.....|::.:|.
Human   507 IKVWAIACFA----PQ--RQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFR 565

  Fly   880 DLKRSQH--DLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLKINSK 942
            .||.:..  .|.:||:|.....|..:|:..:...|:.|||::...|:| ...||:.|:.||||.|
Human   566 HLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQR-TTPQTLSNLCLKINVK 629

  Fly   943 LNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGA 1006
            |.|:|:.:....|.|:.:. .:::|||||||.....:.||:..|..|.|.:...|....|:|:..
Human   630 LGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHR 694

  Fly  1007 LEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKV--GCK 1068
            .|.|:|:.::..|.| :.||..| ..|..||:||||||:|||.::.:.||..|::||.|:  ..:
Human   695 QEIIQDLAAMVRELLIQFYKSTR-FKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQ 758

  Fly  1069 PKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTR 1133
            |.|..::|.||||||.|.:.......|..|:..||.||..|.||.|..|::.||..||||::|:.
Human   759 PGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSH 823

  Fly  1134 YNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYL 1186
            |:|:.:......|.||.|||.|||.:.||.||||.|||||.|||||.|.|.:|
Human   824 YHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHL 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	260/802 (32%)
		ArgoN	411..543	CDD:293095	35/137 (26%)
		ArgoL1	554..601	CDD:285861	18/51 (35%)
		PAZ	605..719	CDD:239207	41/122 (34%)
		Piwi_ago-like	764..1186	CDD:240015	151/432 (35%)
AGO2	XP_011515270.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930