Protein Alignment AGO2 and AGO2

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_011515267.1
• Gene: AGO2 / 27161
• HGNCID: 3263
• Length: 873
• Species: Homo sapiens
• Alignment Length: 832
• Identity: 270/832 - (32%)
• Similarity: 417/832 - (50%)
• Gaps: 62/832 - (7%)

  Fly   389 PPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPER-PKKFYR 452
            ||...|......||:|    ..||.|:..::..|:.::|:.|:.  .|||::.|.||: |::..|
Human    28 PPPPIQGYAFKPPPRP----DFGTSGRTIKLQANFFEMDIPKID--IYHYELDIKPEKCPRRVNR 86

  Fly   453 QAFE----QFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVT-DRNGRTLRYTIEIKETGD 512
            :..|    .|:....|.....:||:.:.|:...||:.....|:.|| ...|:...:.:.||..
Human    87 EIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWV-- 149

  Fly   513 STIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIR---VGRSFFKMSDPNNRHELDDGY 574
            |.:.|::|...::.|:...|...:|.::||:.   |..::|   ||||||..|: ...:.|..|.
Human   150 SCVSLQALHDALSGRLPSVPFETIQALDVVMR---HLPSMRYTPVGRSFFTASE-GCSNPLGGGR 210

  Fly   575 EALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYL-ERFSLKAKINNTTNLDYSRR-- 631
            |...|.:|:.    ||     .||:|:|..:|..:.|:||:: |....|:.......|..|:|
Human   211 EVWFGFHQSV----RPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVK 271

  Fly   632 FLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETF---EHDGKKV--TIASYFHSRN-Y 690
            |.:. ::|:.|..|.....:   |.|||..::|.|||.:||   :..|:.|  |:|.||..|: .
Human   272 FTKE-IKGLKVEITHCGQMK---RKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKL 332

  Fly   691 PLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLL 755
            .|::|.|.||.||...|...||:|:|:|..||...:|....|.:.||:..|.|...|:.:|..|:
Human   333 VLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLM 397

  Fly   756 QYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEY--HSKRFTMVKNGSWRMDGMKF---LEP 815
            :....|.||.:..|||.:.::...|:.|||.||.:.|  .:|.......|.|.|...:|   :|.
Human   398 RSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEI 462

  Fly   816 KPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLDTIFAD 880
            |..|..|..    |:  |:.....|..|...:....:...:.:.....:..:.....|::.:|..
Human   463 KVWAIACFA----PQ--RQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRH 521

  Fly   881 LKRSQH--DLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLKINSKL 943
            ||.:..  .|.:||:|.....|..:|:..:...|:.|||::...|:| ...||:.|:.||||.||
Human   522 LKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQR-TTPQTLSNLCLKINVKL 585

  Fly   944 NGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGAL 1007
            .|:|:.:....|.|:.:. .:::|||||||.....:.||:..|..|.|.:...|....|:|:...
Human   586 GGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQ 650

  Fly  1008 EEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKV--GCKP 1069
            |.|:|:.::..|.| :.||..| ..|..||:||||||:|||.::.:.||..|::||.|:  ..:|
Human   651 EIIQDLAAMVRELLIQFYKSTR-FKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQP 714

  Fly  1070 KICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRY 1134
            .|..::|.||||||.|.:.......|..|:..||.||..|.||.|..|::.||..||||::|:.|
Human   715 GITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHY 779

  Fly  1135 NVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYL 1186
            :|:.:......|.||.|||.|||.:.||.||||.|||||.|||||.|.|.:|
Human   780 HVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHL 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	18/72 (25%)
		ArgoL1	554..601	CDD:462567	18/51 (35%)
		PAZ	605..719	CDD:239207	41/122 (34%)
		Piwi_ago-like	764..1186	CDD:240015	151/432 (35%)
AGO2	XP_011515267.1	ArgoN	106..180	CDD:465134	17/74 (23%)
		ArgoL1	190..240	CDD:462567	19/57 (33%)
		PAZ_argonaute_like	241..361	CDD:239212	42/128 (33%)
		Piwi_ago-like	406..831	CDD:240015	151/431 (35%)