DRSC/TRiP Functional Genomics Resources

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Protein Alignment AGO2 and AGO4

DIOPT Version :9

Sequence 1:NP_730054.1 Gene:AGO2 / 39683 FlyBaseID:FBgn0087035 Length:1217 Species:Drosophila melanogaster
Sequence 2:NP_060099.2 Gene:AGO4 / 192670 HGNCID:18424 Length:861 Species:Homo sapiens


Alignment Length:847 Identity:272/847 - (32%)
Similarity:416/847 - (49%) Gaps:82/847 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   388 GPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPE-RPKKFY 451
            |||     |.|..||:..|   .||:|||.::..|:..:.:.|:.  .|||||.|.|| ||::..
Human     7 GPP-----ASLFQPPRRPG---LGTVGKPIRLLANHFQVQIPKID--VYHYDVDIKPEKRPRRVN 61

  Fly   452 RQAFE----QFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVT-DRNGRTLRYTIEIKETG 511
            |:..:    .|::...|.....||||.:.|:...||:.....::.|| ...|:...:.:.::.. 
Human    62 REVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWV- 125

  Fly   512 DSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIR---VGRSFFKMSDPNN-RHELDD 572
             |.:.|:.|...:...:.:.|..::|.::|:..   |..::|   ||||||  |.|.. .|.|..
Human   126 -SVVSLQLLLEALAGHLNEVPDDSVQALDVITR---HLPSMRYTPVGRSFF--SPPEGYYHPLGG 184

  Fly   573 GYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYLERFSLKAKINNTTN--LDYSR 630
            |.|...|.:|:.    ||     .||:|:|..:|..:.|:||::........||..|.  .|..|
Human   185 GREVWFGFHQSV----RPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQR 245

  Fly   631 RFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGK--KVTIASYFHSR-N 689
            ......:||:.|..|.....:   |.|||..::|.|||.:||.   .:|:  :.|:|.||..: :
Human   246 VKFTKEIRGLKVEVTHCGQMK---RKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYS 307

  Fly   690 YPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNL 754
            ..||:|.|.||.||...|...||:|:|:|..||...:|....|.:.|||..|.|...|:.:|..|
Human   308 LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRL 372

  Fly   755 LQYFQHNL----DPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMV--KNGSWRMDGMKF- 812
            ::  .:::    ||.:..|||.:.|:...::.|||..|.::|..:..|:.  ..|.|.|.|.:| 
Human   373 VK--SNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFY 435

  Fly   813 --LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLD 875
              :|.|..|..|..    |:  ::.....|..|.:.:....|...:.:.....:..:.....|::
Human   436 AGIEIKVWAVACFA----PQ--KQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVE 494

  Fly   876 TIFADLKRSQ--HDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLK 938
            .:|..||.:.  ..|.:||:|.....|..:|:..:...|:.|||::...|. |.:.||:.|:.||
Human   495 PMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVV-KTSPQTLSNLCLK 558

  Fly   939 INSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYRL 1002
            ||:||.|||:.:....|..:.:. .:::|||||||.....:.||:..|..|.|.:.:.|....|:
Human   559 INAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRV 623

  Fly  1003 QRG----------ALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELR 1056
            |..          :.|.|:|:.::..|.| :.||..| ..|..|||||.|||:||..::...||.
Human   624 QTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR-FKPTRIIYYRGGVSEGQMKQVAWPELI 687

  Fly  1057 CIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFM 1119
            .|::||..:  ..:|.|..::|.||||||.|.:.......|..||..||.||.||.||:|..|::
Human   688 AIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYL 752

  Fly  1120 VSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRV 1184
            .||..||||::|:.|.|:.:......|.||.|||.|||.:.||.||||.|||||.|.|||.|.|.
Human   753 CSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARY 817

  Fly  1185 YL 1186
            :|
Human   818 HL 819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AGO2NP_730054.1 PLN03202 411..1180 CDD:215631 260/816 (32%)
ArgoN 411..543 CDD:293095 36/137 (26%)
ArgoL1 554..601 CDD:285861 20/52 (38%)
PAZ 605..719 CDD:239207 40/121 (33%)
Piwi_ago-like 764..1186 CDD:240015 150/442 (34%)
AGO4NP_060099.2 ArgoN 26..155 CDD:406799 32/132 (24%)
ArgoL1 166..216 CDD:400854 21/55 (38%)
PAZ_argonaute_like 217..337 CDD:239212 40/122 (33%)
Piwi_ago-like 384..819 CDD:240015 150/442 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 825..846
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1041
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58336
OrthoDB 1 1.010 - - D159407at2759
OrthoFinder 1 1.000 - - FOG0000468
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22891
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.930

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