DRSC/TRiP Functional Genomics Resources

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Protein Alignment AGO2 and AGO3

DIOPT Version :9

Sequence 1:NP_730054.1 Gene:AGO2 / 39683 FlyBaseID:FBgn0087035 Length:1217 Species:Drosophila melanogaster
Sequence 2:NP_079128.2 Gene:AGO3 / 192669 HGNCID:18421 Length:860 Species:Homo sapiens


Alignment Length:846 Identity:272/846 - (32%)
Similarity:415/846 - (49%) Gaps:77/846 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   386 SRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPER-PKK 449
            |.||...|   ||.:.|:..|   .||:|||.::..|...:::.|:.  .|.|:|.|.|:: |::
Human     5 SAGPAGAQ---PLLMVPRRPG---YGTMGKPIKLLANCFQVEIPKID--VYLYEVDIKPDKCPRR 61

  Fly   450 FYRQA----FEQFRVDQLGGAVLAYDGKASCYSVDKLPL--NSQNPEVTVTDRNGRTLRYTIEIK 508
            ..|:.    .:.|:|...|.....||||.|.|:.:.||:  ...:.:||:....|:...:.:.||
Human    62 VNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIK 126

  Fly   509 ETGDSTIDLKSLTTYMNDRI------FDKPM--RAMQCVEVVLASPCHNKAIRVGRSFFKMSDPN 565
            ..  |.:....|...:..|.      .|||:  ..:..|:|||......|...||||||...:..
Human   127 FV--SRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGY 189

  Fly   566 NRHELDDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYLERFSLKAKINNTTN 625
            : |.|..|.|...|.:|:.    ||     .||:|:|..:|..:.|:|:::      .::.:..|
Human   190 D-HPLGGGREVWFGFHQSV----RPAMWKMMLNIDVSATAFYKAQPVIQFM------CEVLDIHN 243

  Fly   626 LDYSRRFLEPF--------LRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGKKV 679
            :|...|.|...        ::|:.|..|...:.:   |.|||..::|.|||.:||.   .:|:.|
Human   244 IDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMR---RKYRVCNVTRRPASHQTFPLQLENGQTV 305

  Fly   680 --TIASYFHSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAA 741
              |:|.||..: ...||:|.|.||.||...|...||:|:|:|..||...:|....|.:.|||..|
Human   306 ERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATA 370

  Fly   742 TSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMV--KNGS 804
            .|...|:.:|..|::...:..||.:..|..::.::...|:.|||..|.::|..:..|:.  .:|.
Human   371 RSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGV 435

  Fly   805 WRMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRP 866
            |.|.|.:|   :|.|..|..|..      :.|:.....|..|.:.:....|...:.:.....:..
Human   436 WDMRGKQFHTGVEIKMWAIACFA------TQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCK 494

  Fly   867 FTDDERSLDTIFADLKR--SQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNN 929
            :.....|::.:|..||.  |...|.|||:|.....|..:|:..:...|:.|||::...| .|.:.
Human   495 YAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNV-IKTSP 558

  Fly   930 QTIGNILLKINSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPYG 993
            ||:.|:.||||.||.|||:.:....|..:.:. .:::|||||||.....:.||:..|..|.|.:.
Human   559 QTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHP 623

  Fly   994 ASYNMQYRLQRGALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRC 1057
            :.|....|:||...|.|:|:.|:..|.| :.||..| ..|..||:||||||:|||.::...||..
Human   624 SRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTR-FKPTRIIFYRDGVSEGQFRQVLYYELLA 687

  Fly  1058 IKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMV 1120
            |::||..:  ..:|.|..::|.||||||.|.:.......:..|:..||.||..|.||.|..|::.
Human   688 IREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLC 752

  Fly  1121 SHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVY 1185
            ||..||||::|:.|:|:.:......|.||.|||.|||.:.||.||||.|||||.|||||.|.|.:
Human   753 SHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYH 817

  Fly  1186 L 1186
            |
Human   818 L 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AGO2NP_730054.1 PLN03202 411..1180 CDD:215631 260/813 (32%)
ArgoN 411..543 CDD:293095 38/146 (26%)
ArgoL1 554..601 CDD:285861 18/51 (35%)
PAZ 605..719 CDD:239207 38/127 (30%)
Piwi_ago-like 764..1186 CDD:240015 151/432 (35%)
AGO3NP_079128.2 ArgoN 73..167 CDD:406799 24/95 (25%)
ArgoL1 177..227 CDD:400854 19/54 (35%)
PAZ_argonaute_like 228..348 CDD:239212 38/128 (30%)
Piwi_ago-like 393..818 CDD:240015 151/432 (35%)
Interaction with guide RNA. /evidence=ECO:0000305|PubMed:29040713 530..567 11/37 (30%)
Interaction with guide RNA. /evidence=ECO:0000305|PubMed:29040713 758..805 24/46 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1041
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58336
OrthoDB 1 1.010 - - D159407at2759
OrthoFinder 1 1.000 - - FOG0000468
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22891
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.930

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