DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and wago-5

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_495151.3	Gene:	wago-5 / 191545	WormBaseID:	WBGene00022877	Length:	912	Species:	Caenorhabditis elegans

Alignment Length:	910	Identity:	212/910 - (23%)
Similarity:	368/910 - (40%)	Gaps:	169/910 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 PPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSV---AYHYDVKIMPERPKKFYRQAFEQFRV-- 460
            |.:|      ||:||...||.|...::::|..:|   ..|....:...:...|.::..|.|.|
Worm    43 PTEP------GTLGKQVDVGTNIFGVEVTKETTVHRFVVHAKADLTSTKEVTFTKKGKEDFVVLD 101

  Fly   461 --------------------DQLGGAVLAYDGKASCYSVDKL--PLNSQNPEVTVTDRNG----- 498
                                ....|..:.|||:::.|:...|  .|:....:..|...||
Worm   102 RREKCCNLFFNAVEKNPDFFKMKDGNHIVYDGQSTLYTTINLFSELDCNQTKSKVFQINGADTGN 166

  Fly   499 ---RTLR-YTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRA-----MQCVEVVLASPCHNKAIRV 554
               :||. .::||....|::|.:.:  ..:.:|..|:.:..     .|.:|:.|...|..:..|.
Worm   167 DELKTLPCISLEIHAPRDNSITISA--KILGERTADQNIEVNNREYTQFLELALNQHCTRETKRF 229

  Fly   555 -----GRSFFKMS-----DPNNRHELDDGYEALVGLYQAFMLGDRPF--------LNVDISHKSF 601
                 |:.:|..:     |..:..::.||.....||.:.....:.||        |.:|....:|
Worm   230 GCFEHGKVYFLNATEEGFDQRDCVDVGDGKALYPGLKKTIQFIEGPFGRGQNNPSLVIDGMKAAF 294

  Fly   602 PISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINV--VYTPPQSFQSAPRVYRVNGLSR 664
            .....:|:.|...:.:...|..:::  :|....|.::|::.  :||      |..|..|:.|:..
Worm   295 HKEQTVIQKLFEITGQDPSNGLSSM--AREKATPVIKGLDCYSMYT------SRKRHLRIVGIFH 351

  Fly   665 APASSETFE-HDGKKVTIASYFHSR-NYPLKFPQLH---CLNVGSSIKSILLPIELCSIEEGQAL 724
            ..|:...|| .|||..:||.||..: :..|::|:.:   |.:.|:   :...|.||.:|.:.|..
Worm   352 ESATGTRFELPDGKTCSIAEYFRDKYSINLQYPKANLVVCKDRGN---NNYFPAELMTISKNQRA 413

  Fly   725 NRKDGATQVANMIKYAATSTNVRKRKI------MNLLQYFQHNLDPTISRFGIRIANDFIVVSTR 783
            .... .||.....|..|...:||:|.|      :|:..  ::.|   ::..||::.::.:.||.:
Worm   414 TIPQ-QTQSQKTTKECAVLPDVRQRIIIKGKTAVNITA--ENEL---LNALGIKVYSEPLKVSLK 472

  Fly   784 VLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLII 848
            .|.      :.:.....:.|.||.....|::|.......| ||.......:.:.:.|:.|..:.|
Worm   473 ELG------YQRSTVKSELGKWRPPPGSFVKPAAFQDLWA-LYAVGNQNSRFSVSDLSQFTGMFI 530

  Fly   849 SQGKAVNISLDSDVTYRPFTDDERSL---DTIFADLKR---SQHDLAIVI----IPQFRISYDTI 903
            ...|...:.:      :|  ..|.||   |.|.:.|:.   |:...|.||    |......|..:
Worm   531 DACKKRGMII------KP--PSETSLCHMDNIISLLENAAASKCKFAFVITDDSITHLHKKYKAL 587

  Fly   904 KQKAELQHGIL--TQCIKQFTVERKCNNQTIGNILLKINSKLNGINHKIKDDPRLPMMKNTMYIG 966
            :||:.:   ::  .:..|..:|.:.....|:.|::.|.|.||.|:|:.: .|.:..|....:.||
Worm   588 EQKSMM---VIQDMKISKANSVVKDGKRLTLENVINKTNMKLGGLNYTV-SDAKKSMTDEQLIIG 648

  Fly   967 ADVTHPSPDQREI--------PSVVGVA----ASHD--------PYGASYNMQYRLQRGALEEIE 1011
            ..|:.|....:.:        |.::|.|    |:|:        |.|          :..:..||
Worm   649 VGVSAPPAGTKYMMDNKGHLNPQIIGFASNAVANHEFVGDFVLAPSG----------QDTMASIE 703

  Fly  1012 DMFSITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKVGCKPKICCVIV 1076
            |:...:::   :::..||..|..||.||.|.|||....|...|:...:...........:..:||
Worm   704 DVLKSSID---LFEMNRNTLPKRIIIYRSGASDGSHASILAYEIPLARATIQGYSKDINLIYIIV 765

  Fly  1077 VKRHHTRFF----PSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVI 1137
            .|.|..|||    .||...|.   .|:.||.|:|..:.:|...|||:..|..:|||||...|.::
Worm   766 TKEHSYRFFRDQLRSGGKATE---MNIPPGIVLDSAVTNPACKQFFLNGHTTLQGTAKTPLYTIL 827

  Fly  1138 ENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGR-VYLTGTNRFLDLKKEYAK 1201
            .:..|..:|.|::|||.|||.......|.|.|.|.|:|:..|.||| ::..|.|...:..:|:.|
Worm   828 ADDCNAPMDRLEELTYTLCHHHQIVALSTSIPTPLYVANEYAKRGRDLWAHGPNEANEYHEEHLK 892

Fly 1202 1201
Worm 893 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	202/876 (23%)
		ArgoN	411..543	CDD:293095	34/172 (20%)
		ArgoL1	554..601	CDD:285861	11/64 (17%)
		PAZ	605..719	CDD:239207	29/120 (24%)
		Piwi_ago-like	764..1186	CDD:240015	116/458 (25%)
wago-5	NP_495151.3	ArgoN	47..>143	CDD:293095	19/95 (20%)
		PAZ_argonaute_like	297..407	CDD:239212	29/120 (24%)
		Piwi	568..876	CDD:280353	91/327 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.870