DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and alg-1

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_001367206.1	Gene:	alg-1 / 181504	WormBaseID:	WBGene00000105	Length:	1023	Species:	Caenorhabditis elegans

Alignment Length:	1039	Identity:	297/1039 - (28%)
Similarity:	451/1039 - (43%)	Gaps:	180/1039 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 GGYQQRPSGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPP---GQQPNQTQ 379
            ||.|..| |......||..|.....:  .|||.........:.....|..|:||   .|....|.
Worm    24 GGPQYLP-GVMNSTIQQQPQSATSSF--LPSGPISSTSTSSQVVPTSGATQQPPFPSAQAAASTA 85

  Fly   380 SQGQYQS--RGPPQQQQAAPLPLPPQPAGSIKRG--------TIGKP------------------ 416
            .|...:.  ..||.|.|... .:|.:.|||:..|        :||:|
Worm    86 LQNDLEEIFNSPPTQPQTFS-DVPQRQAGSLAPGVPIGNTSVSIGEPANTLGGGLPGGAPGQLPG 149

  Fly   417 -GQVGINYLDLDLSKMPS----------------------VAYHYDVKIMPER-PKKFYRQ---- 453
             .|.||.:   ...:.|:                      ...||.|.:.|:: |::..|:
Worm   150 GNQSGIQF---QCPRRPNHGVEGRSILLRANHFAVRIPGGTIQHYQVDVTPDKCPRRVNREIISC 211

  Fly   454 ---AFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNP--EVTVTDRNGRTLRYTIEIKETGDS 513
               ||.::    .......||||.:.|:.:.||:..:..  :||:...:....::::.:|..|.
Worm   212 LISAFSKY----FTNIRPVYDGKRNMYTREPLPIGRERMDFDVTLPGDSAVERQFSVSLKWVGQ- 271

  Fly   514 TIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPN------------- 565
             :.|.:|...|..|:...|..|:|.::|:|......|...||||||....||
Worm   272 -VSLSTLEDAMEGRVRQVPFEAVQAMDVILRHLPSLKYTPVGRSFFSPPVPNASGVMAGSCPPQA 335

  Fly   566 ------NRH---------ELDDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEY 610
                  ..|         :|..|.|...|.:|:.    ||     .||:|:|..:|..|||:||:
Worm   336 SGAVAGGAHSAGQYHAESKLGGGREVWFGFHQSV----RPSQWKMMLNIDVSATAFYRSMPVIEF 396

  Fly   611 L--------ERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPA 667
            :        :..:.:..:::...:.:::.     :||:.:..|.....:   |.|||..::|.||
Worm   397 IAEVLELPVQALAERRALSDAQRVKFTKE-----IRGLKIEITHCGQMR---RKYRVCNVTRRPA 453

  Fly   668 SSETFE---HDGKKV--TIASYFHSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNR 726
            .::||.   ..|:.:  |:|.||:.: ...||:|.|.||.||...|...||.|:|:|..||...:
Worm   454 QTQTFPLQLETGQTIECTVAKYFYDKYRIQLKYPHLPCLQVGQEQKHTYLPPEVCNIVPGQRCIK 518

  Fly   727 KDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVE 791
            |....|.:.|||..|.|...|:|:|.||::..:.:.||....|||.|......|..||||.|::.
Worm   519 KLTDVQTSTMIKATARSAPEREREISNLVRKAEFSADPFAHEFGITINPAMTEVKGRVLSAPKLL 583

  Fly   792 YHSK-RFTMVKN-GSWRMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQLND---FGNLII 848
            |..: |.|.:.| |.|.|.|.:|   ::.:..|..|..         :..:.:.||   |.|.:.
Worm   584 YGGRTRATALPNQGVWDMRGKQFHTGIDVRVWAIACFA---------QQQHVKENDLRMFTNQLQ 639

  Fly   849 SQGKAVNISLDSDVTYRPFTDDERSLDTIFADLKR--SQHDLAIVIIPQFRISYDTIKQKAELQH 911
            .......:.:..:..:..:......::.:|..||:  |...|.:|::|.....|..:|:..:...
Worm   640 RISNDAGMPIVGNPCFCKYAVGVEQVEPMFKYLKQNYSGIQLVVVVLPGKTPVYAEVKRVGDTVL 704

  Fly   912 GILTQCIKQFTVERKCNNQTIGNILLKINSKLNGINHKIKDDPRLPMMKN--TMYIGADVTHPSP 974
            ||.|||::.....| ...||:.|:.||:|.||.|:|..:..:.| |.:.|  .::.|.|:|||..
Worm   705 GIATQCVQAKNAIR-TTPQTLSNLCLKMNVKLGGVNSILLPNVR-PRIFNEPVIFFGCDITHPPA 767

  Fly   975 DQREIPSVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNA--YPDHIIY 1037
            .....||:..|..|.|.:.:.|....|:|:...|.|.|:..:..|.|..:  |||.  .|..|:.
Worm   768 GDSRKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIISDLTYMVRELLVQF--YRNTRFKPARIVV 830

  Fly  1038 YRDGVSDGQFPKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVD 1100
            ||||||:|||..:...|||.|::||..:  |.:|.|..:.|.||||||.|.........|..|:.
Worm   831 YRDGVSEGQFFNVLQYELRAIREACMMLERGYQPGITFIAVQKRHHTRLFAVDKKDQVGKAYNIP 895

  Fly  1101 PGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRS 1165
            |||.||..|.||.|..|::.||..||||::|:.|:|:.:..||..|.||||||.:||.:.||.||
Worm   896 PGTTVDVGITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNNLTADELQQLTYQMCHTYVRCTRS 960

  Fly  1166 VSYPAPAYLAHLVAARGRVYL-------------TGTNRFLDLKKEYAKRTIVPEFMKKNPMYF 1216
            ||.|||||.|||||.|.|.:|             :||:....|........:.|:  ..|.|||
Worm   961 VSIPAPAYYAHLVAFRARYHLVDREHDSGEGSQPSGTSEDTTLSNMARAVQVHPD--ANNVMYF 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	259/890 (29%)
		ArgoN	411..543	CDD:293095	35/190 (18%)
		ArgoL1	554..601	CDD:285861	20/79 (25%)
		PAZ	605..719	CDD:239207	34/127 (27%)
		Piwi_ago-like	764..1186	CDD:240015	153/437 (35%)
alg-1	NP_001367206.1	ArgoN	170..300	CDD:406799	27/135 (20%)
		ArgoL1	310..389	CDD:400854	21/82 (26%)
		PAZ_argonaute_like	390..511	CDD:239212	35/128 (27%)
		Piwi_ago-like	556..981	CDD:240015	153/437 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.980