Protein Alignment AGO2 and nrde-3

DIOPT Version :9

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_508092.1
• Gene: nrde-3 / 180392
• WormBaseID: WBGene00019862
• Length: 1057
• Species: Caenorhabditis elegans
• Alignment Length: 1083
• Identity: 221/1083 - (20%)
• Similarity: 372/1083 - (34%)
• Gaps: 314/1083 - (28%)

  Fly   358 GRQGQEGGYQQRPPGQQPNQTQSQGQYQSRGPPQQQQAAPLPL---PPQPAGSI-----KRGTIG 414
            |..|.:.|...:.|....:.|.....:.:...|..||..|.||   |....||:     ||....
 Worm     9 GEMGSKPGSTAKKPATSASSTPRTNVWGTAKKPSSQQQPPKPLFTTPGSQQGSLGGRIPKREHTD 73

  Fly   415 KPG-----------------------QVGINYLDLDLSKMPS----------------------- 433
            :.|                       :|.:|..:||:|||..
 Worm    74 RTGPDPKRKPLGGLSVPDSFNNFGTFRVQMNAWNLDISKMDERISRIMFRATLVHTDGRRFELSL 138

  Fly   434 --VAYHYDVKIMPERP------KKFYRQAFEQFRVDQLGGAVLAYDGKASCY---SVDKLPLNSQ 487
              .|:..||.....|.      :.::::..|.|: .....|:.|||...:.|   |...:.|...
 Worm   139 GVSAFSGDVNRQQRRQAQCLLFRAWFKRNPELFK-GMTDPAIAAYDAAETIYVGCSFFDVELTEH 202

  Fly   488 NPEVTVTDRNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAM---------QCVEVVL 543
            ...:|..|.:.:..:....|.....||.:::..|   |..|:.:...|:         :.:|.:.
 Worm   203 VCHLTEADFSPQEWKIVSLISRRSGSTFEIRIKT---NPPIYTRGPNALTLENRSELTRIIEAIT 264

  Fly   544 ASPCHNKAIRVGRSFFKMSD---PNNRHELDDGYEALV---GLYQAFMLGDR-----PFLNVDIS 597
            ....||:      .|...|.   |....::....|..:   |..:...:.||     ..:.||.:
 Worm   265 DQCLHNE------KFLLYSSGTFPTKGGDIASPDEVTLIKSGFVKTTKIVDRDGVPDAIMTVDTT 323

  Fly   598 HKSFPISMPMIEYLERFSLKAKINNTTN----------------------------------LDY 628
            ...|.....::::     ..||::..||                                  :||
 Worm   324 KSPFYKDTSLLKF-----FTAKMDQLTNSGGGPRGHNGGRERRDGGGNSRKYDDRRSPRDGEIDY 383

  Fly   629 SRRFLEPFLRGI-------NVVYTPPQSFQ------------SAPRVYRVNGLSRAPASSETFEH 674
            ..|.:..:.|..       .::.|..||.:            .|.|...::.:....|.|.|||.
 Worm   384 DERTVSHYQRQFQDERISDGMLNTLKQSLKGLDCQPIHLKDSKANRSIMIDEIHTGTADSVTFEQ 448

  Fly   675 ---DG--KKVTIASYFHSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQV 733
               ||  |..:|..|:..| ||.||||.|..:....:......|:||.||..||.:.:......:
 Worm   449 KLPDGEMKLTSITEYYLQRYNYRLKFPHLPLVTSKRAKCYDFYPMELMSILPGQRIKQSHMTVDI 513

  Fly   734 ANMIKYAATS---TNVRKRKIMNLLQYFQHNLDPT---ISRFGIRIAN-DFIVVSTRVLSPPQVE 791
            .:.:....:|   .::::.|:: |.:|.:....|.   :..|.:.:.: ..||.:...||||.::
 Worm   514 QSYMTGKMSSLPDQHIKQSKLV-LTEYLKLGDQPANRQMDAFRVSLKSIQPIVTNAHWLSPPDMK 577

  Fly   792 YHSKRFTMVK---------NGSWRM---------------------------------DGMKFLE 814
            :.:.:...:.         ||.:.|                                 .|||| :
 Worm   578 FANNQLYSLNPTRGVRFQTNGKFVMPARVKSVTIINYDKEFNRNVDMFAEGLAKHCSEQGMKF-D 641

  Fly   815 PKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLDTIFA 879
            .:|.:.|...|....|.|.|:...:       .|..|..:...                   |.|
 Worm   642 SRPNSWKKVNLGSSDRRGTKVEIEE-------AIRNGVTIVFG-------------------IIA 680

  Fly   880 DLKRSQHDLAIVIIPQF--RISYDTIKQKAEL------QHGILTQCIKQFTVERKCNNQTIGNIL 936
            :.:...||    |:..|  ::...||:..:|.      .||               ..|||.|::
 Worm   681 EKRPDMHD----ILKYFEEKLGQQTIQISSETADKFMRDHG---------------GKQTIDNVI 726

  Fly   937 LKINSKLNGIN----------HKI----KDDPRLPMMKNTMYIGADVTHPSP----DQREI---- 979
            .|:|.|..|.|          |::    ..:.|..:...|.:||.:::|...    |.:::
 Worm   727 RKLNPKCGGTNFLIDVPESVGHRVVCNNSAEMRAKLYAKTQFIGFEMSHTGARTRFDIQKVMFDG 791

  Fly   980 -PSVVGVAAS--HDPY--GASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNAYPDHIIYYR 1039
             |:|||||.|  |...  |.||..:.||.:  |..:::...|.   |..|::..:..|:.::.||
 Worm   792 DPTVVGVAYSLKHSAQLGGFSYFQESRLHK--LTNLQEKMQIC---LNAYEQSSSYLPETVVVYR 851

  Fly  1040 DGVSDGQFPKIKNE--ELRCIKQACDKVGCKPKICCVIVVKRHHTRFFPSGDVTTSNKF--NNVD 1100
            .|..:|.:|:|.||  |::...:. .|.|..||...:...:..|.|.||. .:....|.  .||.
 Worm   852 VGSGEGDYPQIVNEVNEMKLAARK-KKHGYNPKFLVICTQRNSHIRVFPE-HINERGKSMEQNVK 914

  Fly  1101 PGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRS 1165
            .||.||.........:|.:.....:.||.|||:|.:|.|......:.:..:||:|...     ..
 Worm   915 SGTCVDVPGASHGYEEFILCCQTPLIGTVKPTKYTIIVNDCRWSKNEIMNVTYHLAFA-----HQ 974

  Fly  1166 VSYPAPA-----YLAHLVAARG-RVYLTGTNRFLDLKKEYAKR 1202
            |||..||     |.|..:|.|| ..|.|.| :.:|: .:|:.|
 Worm   975 VSYAPPAIPNVSYAAQNLAKRGHNNYKTHT-KLVDM-NDYSYR 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	196/997 (20%)
		ArgoN	411..543	CDD:293095	31/197 (16%)
		ArgoL1	554..601	CDD:285861	9/57 (16%)
		PAZ	605..719	CDD:239207	35/172 (20%)
		Piwi_ago-like	764..1186	CDD:240015	114/512 (22%)
nrde-3	NP_508092.1	PAZ_argonaute_like	385..499	CDD:239212	29/113 (26%)
		Piwi	673..1001	CDD:280353	91/377 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910