DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and rde-1

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_741611.1	Gene:	rde-1 / 179393	WormBaseID:	WBGene00004323	Length:	1020	Species:	Caenorhabditis elegans

Alignment Length:	1049	Identity:	221/1049 - (21%)
Similarity:	382/1049 - (36%)	Gaps:	258/1049 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 QGQYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKI--- 442
            :|.|:....|:.:..|      :|.|........|...:.:|:............|.|:||:
Worm    10 KGFYRHSLDPEMKWLA------RPTGKCDGKFYEKKVLLLVNWFKFSSKIYDREYYEYEVKMTKE 68

  Fly   443 -----------------MPERPKKFYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPE 490
                             :|:|.|.|::....:.:..........:|.|.:.|||.:  ||:...:
Worm    69 VLNRKPGKPFPKKTEIPIPDRAKLFWQHLRHEKKQTDFILEDYVFDEKDTVYSVCR--LNTVTSK 131

  Fly   491 VTVTDRNGRTLRYTIEIKETGDSTIDLKSLTTYM--------------NDRIFDKPMRAMQCVEV 541
            :.|::   :.::...|.|:..|  ::.|.|.|.:              |....::..|:.:.::.
Worm   132 MLVSE---KVVKKDSEKKDEKD--LEKKILYTMILTYRKKFHLNFSRENPEKDEEANRSYKFLKN 191

  Fly   542 VLASPC---------------------HNKAIRVGRSFFKMSDPNNRH---ELDDGYEALVGLYQ 582
            |:....                     :|..:||..||   .|||...   |:....||..|:|.
Worm   192 VMTQKVRYAPFVNEEIKVQFAKNFVYDNNSILRVPESF---HDPNRFEQSLEVAPRIEAWFGIYI 253

  Fly   583 AF--MLGDRPFLNVDISHKSF---PISMPMIEYL------------ERFSLKAKI--NNTTNLDY 628
            ..  :....|.||..|..|.|   | .|.:::||            .|..||.|:  ...|....
Worm   254 GIKELFDGEPVLNFAIVDKLFYNAP-KMSLLDYLLLIVDPQSCNDDVRKDLKTKLMAGKMTIRQA 317

  Fly   629 SRRFLEPFLRGINV----VYTPPQS------------FQSAPRVYRVNGLSRAPASSETFEHDGK 677
            :|..:...|..:.:    |:....|            .:....||:|.|.|....:::.::
Worm   318 ARPRIRQLLENLKLKCAEVWDNEMSRLTERHLTFLDLCEENSLVYKVTGKSDRGRNAKKYD---- 378

  Fly   678 KVTIASYFHSRNYPLKFPQLHCLNVGSSIKSILLPIELCSIEE--GQALNRKDGATQVANMIKYA 740
             .|:...:......::||.|..:.|.|..|...:|:|...:.|  .:..||.|...| ...:|.|
Worm   379 -TTLFKIYEENKKFIEFPHLPLVKVKSGAKEYAVPMEHLEVHEKPQRYKNRIDLVMQ-DKFLKRA 441

  Fly   741 ATSTNVRKRKIMNLLQYFQHNLDPT--ISRFGIRIANDFIVVSTRVLSPPQV---EYHSKRFTMV 800
            ....:..|...:.:|:....:.:..  :.|||:......|....:||..|.:   .....:.|.|
Worm   442 TRKPHDYKENTLKMLKELDFSSEELNFVERFGLCSKLQMIECPGKVLKEPMLVNSVNEQIKMTPV 506

  Fly   801 KNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNI--SLDSDVT 863
            ..|...    |.|...|:...|..::.       :|.|.    ||..:.:...|..  .|.....
Worm   507 IRGFQE----KQLNVVPEKELCCAVFV-------VNETA----GNPCLEENDVVKFYTELIGGCK 556

  Fly   864 YRPF---TDDERSLDTIFADLKRSQHD-----------------------------------LAI 890
            :|..   .::.|...:|..|..::::.                                   |..
Worm   557 FRGIRIGANENRGAQSIMYDATKNEYAFYKNCTLNTGIGRFEIAATEAKNMFERLPDKEQKVLMF 621

  Fly   891 VIIPQFRI-SYDTIKQKAELQHGILTQCIKQFTVER--------KCNNQTIGNILLKINSKLNGI 946
            :||.:.:: :|..:|...:...|:..|.|...||.:        |.:.:....|.||||:||.||
Worm   622 IIISKRQLNAYGFVKHYCDHTIGVANQHITSETVTKALASLRHEKGSKRIFYQIALKINAKLGGI 686

  Fly   947 NHKI----------KDDPRLPMMKNTMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYR 1001
            |.::          ::..|...|..|||:|.|||||:.......|:..|.||.:|.|..|.....
Worm   687 NQELDWSEIAEISPEEKERRKTMPLTMYVGIDVTHPTSYSGIDYSIAAVVASINPGGTIYRNMIV 751

  Fly  1002 LQ-------------RGALEEIEDMFSITLEHLRVYKEYR-NAYPDHIIYYRDGVSDGQFPKIKN 1052
            .|             |...:.:|..|   ::.||.:.|.. |..|.||:.|||||||.:..::.:
Worm   752 TQEECRPGERAVAHGRERTDILEAKF---VKLLREFAENNDNRAPAHIVVYRDGVSDSEMLRVSH 813

  Fly  1053 EELRCIKQAC-------DKVGCKPKICCVIVVKRHHTRFF---------------PS-------- 1087
            :|||.:|...       |....:||...:::.|||:||..               |:
Worm   814 DELRSLKSEVKQFMSERDGEDPEPKYTFIVIQKRHNTRLLRRMEKDKPVVNKDLTPAETDVAVAA 878

  Fly  1088 -----GDVTTSNKFNNVDP--GTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDI 1145
                 .|:..|.:...|:|  ||.||:.||...:..||:.||..:.||::|..|.|:.:...:..
Worm   879 VKQWEEDMKESKETGIVNPSSGTTVDKLIVSKYKFDFFLASHHGVLGTSRPGHYTVMYDDKGMSQ 943

  Fly  1146 DLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGR-VYLTGTNRFLDLKKEYAK---RTIVP 1206
            |.:.::||.|..:..||.:.:|.|.|.:.|||...:.: :|.|....::.   :||:   |..:.
Worm   944 DEVYKMTYGLAFLSARCRKPISLPVPVHYAHLSCEKAKELYRTYKEHYIG---DYAQPRTRHEME 1005

  Fly  1207 EFMKKNPMY 1215
            .|::.|..|
Worm  1006 HFLQTNVKY 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	207/978 (21%)
		ArgoN	411..543	CDD:293095	26/165 (16%)
		ArgoL1	554..601	CDD:285861	16/51 (31%)
		PAZ	605..719	CDD:239207	26/143 (18%)
		Piwi_ago-like	764..1186	CDD:240015	125/537 (23%)
rde-1	NP_741611.1	PAZ_argonaute_like	280..419	CDD:239212	26/143 (18%)
rde-1	NP_741611.1	Piwi_ago-like	467..982	CDD:240015	125/532 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870