Protein Alignment AGO2 and sago-1

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_504610.1
• Gene: sago-1 / 179016
• WormBaseID: WBGene00019666
• Length: 881
• Species: Caenorhabditis elegans
• Alignment Length: 923
• Identity: 219/923 - (23%)
• Similarity: 363/923 - (39%)
• Gaps: 213/923 - (23%)

  Fly   396 APLPLPPQPAGSIKRGTI---GKPGQVGINYLDLDLSKMPSVAYHYDVKIM-------------- 443
            ||||:..||....|...:   |.|.|:..|...::|.|..|: :.|.|:::
 Worm    20 APLPVGHQPLAEKKPKEVNQEGTPVQIVTNMRKINLEKNHSI-FKYSVQVLFVYQKSDGTELVLE 83

  Fly   444 ----------PERPK----KFYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVT 494
                      .||.|    :.||:|.:|.:..:.||. ..||.:...||..||..:..:..:|.:
 Worm    84 KSKSVGSGCDHERSKSHCLRVYRKAAKQCQELKSGGP-FCYDSQGCLYSFSKLKNDEFSTNITGS 147

  Fly   495 D--RNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKP-------MRAMQCVEVVLASPC-HN 549
            |  .|.:.||...::.:..:|   .::.|..:...:..:|       :.||.  ::|..:|. |.
 Worm   148 DISNNPKFLRVEFKLAKVQES---FQTTTNDVAKSVNCRPALQEKTILEAMN--QIVSTAPINHP 207

  Fly   550 KAIRVGRSFFKMSDPNNRHELD-------DGYEALVG----------------LYQAFMLGDRPF 591
            ..:.:|.....:.|..|   :|       .|..:.||                ||.|..|....|
 Worm   208 NVLTIGNCVHYLYDDTN---IDIRSITGEGGKSSAVGASKSVRTLEGTGKTPCLYMATELKTTLF 269

  Fly   592 -------LNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPF-LRGINV-----V 643
                   |.|.:.::.|           ..||||.              .|| |:..|.     .
 Worm   270 HPDNCSLLKVFMDYRGF-----------NGSLKAN--------------SPFVLKNKNAFIGLWC 309

  Fly   644 YTPP---QSFQSAPRVYRVN--GLSRAPASSETFEHDGKKVTIASYFHSR-NYPLKFPQLHCLNV 702
            ||..   ..::....:.::.  |||   |...|||.|.||:::.:||..: |..||:|.|..:..
 Worm   310 YTTHGKCSDWKDDRPMIKIKDFGLS---AKETTFERDNKKISVFNYFQVKYNMTLKYPDLFTVVA 371

  Fly   703 -GSSIKSILLPIELCSIEEGQALNRKD-GATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPT 765
             |...|:..:|:|...:...|.:..:. ..|:.|::||.||...:.|| ||          .|..
 Worm   372 RGKDGKNQHIPVECLDLCNSQTVRTEQMVGTEQADLIKLAAAKPHDRK-KI----------TDTV 425

  Fly   766 ISRFGIRIANDFIV-------VSTRVLSPPQVEYHSKRFTMVKNGSWR-----------MDGMKF 812
            ::..|:......|:       |:..||..|.:     .|:..|...|.           |....|
 Worm   426 VNSIGLASEPKGIISVGAPESVTGLVLPKPDI-----YFSGGKKVFWNDPKKRGPATDFMPAGTF 485

  Fly   813 LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDS---DVTYRPFTDDERSL 874
            ::| .|.....|::        .|..||.|....:.|..:.:.:.:.:   .:..|.:      |
 Worm   486 IKP-TKLTNWEVVF--------DNGVQLVDCIQHLTSTMRQLGMEVSNPTVSLINRGY------L 535

  Fly   875 DTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQ-TIGNILLK 938
            .:||.:.|.:...| |:.|.:...:|.|..:..|.:..:|||.|:..|..:....| |..||:.|
 Worm   536 RSIFENAKAANRQL-IMFITKSMNNYHTEIKCLEQEFDLLTQDIRFETAVKLAQQQNTRKNIIYK 599

  Fly   939 INSKLNGINHKIKDDPRLPMMKNT--MYIGADVTHPSPDQR----EIPSVVGVAASHDPYGASYN 997
            .|.||.|:|:::    |..:..|:  :.||.:.:     ||    :.|..:|.||:...:...:.
 Worm   600 TNMKLGGLNYEL----RSGVFSNSKRLIIGFETS-----QRGGLGDAPIAIGFAANMMSHSQQFA 655

  Fly   998 MQYRLQRGALEEIEDMF-SITLEHLRVYKEYR-NAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQ 1060
            ..|...:.:.:....:. .|.|..|:..|..| |..||.::.|..|||:||...:.......:|.
 Worm   656 GGYMFVKKSADNYGPVIPEILLTILKQAKANRPNDRPDELLIYFSGVSEGQHALVNEYYANQVKA 720

  Fly  1061 ACD--KVGCKPKICCVIVVKRHHTRFFPS---GDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMV 1120
            ||.  ....:|.|..::..|.|:||.:.|   |.|.      ||:||||:|.|||.|...:::..
 Worm   721 ACGLFNESFRPHITLILASKVHNTRVYKSENGGGVC------NVEPGTVIDHTIVSPVLSEWYHA 779

  Fly  1121 SHQAIQGTAKPTRYNVIENT-GNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRV 1184
            ...|.|||:|..:|::|.|| .|..:.:.::||..||:.........|.|.|.::|...:.||
 Worm   780 GSLARQGTSKLVKYSLIFNTKKNEKLSVYERLTNELCYEMQIVFHPTSLPIPLHIAGTYSERG-- 842

  Fly  1185 YLTGTNRFLDLKK 1197
                 ::.|.|||
 Worm   843 -----SQMLALKK 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	15/80 (19%)
		ArgoL1	554..601	CDD:462567	14/76 (18%)
		PAZ	605..719	CDD:239207	31/126 (25%)
		Piwi_ago-like	764..1186	CDD:240015	113/457 (25%)
sago-1	NP_504610.1	PAZ	281..412	CDD:198017	37/158 (23%)
		Piwi-like	443..844	CDD:239208	111/443 (25%)